Yes, I have heard of a PSA drop after stopping Casodex. I'm sorry, I don't remember your husband's history. When my husband's PSA began to rise on Lupron, the med. onc. started him on Ketoconazole plus hydrocortisone, a "second-line" hormone therapy in addition to Zoladex. Is your doctor checking PSA every month now? Now is the time to take action if the PSA does not drop after stopping the Casodex.