Efficacy of Proton Beam Radiation

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

John Bonneville
New Member


Date Joined Sep 2008
Total Posts : 15
   Posted 10/9/2008 4:23 AM (GMT -7)   
I recently listened with interest to a podcast interview with Professor Anthony Zietman, (Professor of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School). about half way through the podcast Professor Zietman expresses some concerns re the efficacy of Proton Beam Radiation in treating prostate cancer. The podcast dated 21st of August 2008 is available below

http://www.prostatecancerupdate.com/default.asp

I would be interested to know if anyone has found either supporting or conflicting academic views on the efficacy of proton beam radiation in treating PCa?

My own journey is available on the YANA site below.

http://www.yananow.net/Mentors/JohnB2.htm

Cheers from the sunny springtime, "LAND DOWN UNDER".

tongue tongue
Diagnosed March 2007, Age 57
Positive DRE, 12 Core Biopsy, 6 cores positive PCa,
Gleason 7 (4+3), Stage T2B
Rx 9 months LHRH ADT Lucrin, Neo Adjuvant,
Gold Seed implants 2 weeks prior to EBRT
70gy 3D Conformal EBRT

PSA: Nov 2006 = 6.0 ng/ml
May 2007 = 5.9 ng/ml * 1st Lucrin IMI
Aug 2007 = 0.85 ng/ml* 2nd Lucrin IMI
Nov 2007 = 0.45 ng/ml * 3rd Lucrin IMI
Jan 2008 = 0.29 ng/ml * 8 weeks EBRT and TURP in May
June 2008 = 0.12 ng/ml
Sept 2008 = 0.14 ng/ml

Post Edited (John Bonneville) : 10/9/2008 7:10:20 AM (GMT-6)


divo
Veteran Member


Date Joined Jul 2008
Total Posts : 637
   Posted 10/9/2008 4:52 AM (GMT -7)   
John, I am interested in your post. I tried to access the information, but did not see the Zeitman podcast (there were many other)... How did you access it... Di
Husband Pete
dx Jan 2001 age 67 gleason 4 + 3 PSA 16.5
seed implant and conformal radiation Lupron from Jan 2001 to Jan2002
2005 Dec PSA began to rise from .5 to 8 within 6 months
Salvage surgery at MSK 9/06
Fistula operation 2/07 MSK
Many cystoscopies and ER visits with strictures
catheter for one year....Catheter taken out Sept 07..
Total Incontinence since then....
PSA .52 3/07
AUS Operation at MSK Sept 8. Dr. Sandhu
Waiting for activation October 21 2008


John Bonneville
New Member


Date Joined Sep 2008
Total Posts : 15
   Posted 10/9/2008 5:05 AM (GMT -7)   
Hi di
Click on the "Listen to Audio Files" icon. Look for Track 5 by Professor Zietman entitled, "Proton Beam Radiation" Or cut and paste the link below.

http://www.prostatecancerupdate.com/download-audio/pcu/2008/2/PCU208_Zietman/PCU2_2008_Zietman_05.mp3
Diagnosed March 2007, Age 57
Positive DRE, 12 Core Biopsy, 6 cores positive PCa,
Gleason 7 (4+3), Stage T2B
Rx 9 months LHRH ADT Lucrin, Neo Adjuvant,
Gold Seed implants 2 weeks prior to EBRT
70gy 3D Conformal EBRT

PSA: Nov 2006 = 6.0 ng/ml
May 2007 = 5.9 ng/ml * 1st Lucrin IMI
Aug 2007 = 0.85 ng/ml* 2nd Lucrin IMI
Nov 2007 = 0.45 ng/ml * 3rd Lucrin IMI
Jan 2008 = 0.29 ng/ml * 8 weeks EBRT and TURP in May
June 2008 = 0.12 ng/ml
Sept 2008 = 0.14 ng/ml

Post Edited (John Bonneville) : 10/9/2008 7:11:34 AM (GMT-6)


Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1210
   Posted 10/9/2008 1:37 PM (GMT -7)   
Hi John,
 
Thanks for posting the URL full of interesting and informative sound files. Hope you'll continue to do well.
All the best to you.
 
Magaboo

Born Sept., 1936
PSA 7.9
Stage T1C
-ve DRE
Gleason's Score 3+4=7
2 of 8 positive
open RP 28 Nov 06
Post op staging T3a
Gleasons still 3+4=7
Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06
Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08
Next step: Salvage RT


PAN
New Member


Date Joined Nov 2007
Total Posts : 9
   Posted 10/10/2008 5:55 PM (GMT -7)   
Having gone through treatment at Loma Linda I have a slightly different view of Professor Zietman's comments regarding proton radiation for treating prostate cancer. He is absolutely correct in his discussion of the role prostate patients play in funding the treatment of the unique and deadly cancers of the spine, neck, head and eye. He does imply it may not be ethical to treat prostate cancer patients in lieu of the other cancer. I understood as of last May (2008) when I left Loma Linda only 65% of the Loma Linda proton treated patients were prostate cancer patients. In like fashion Massachusetts only uses about 10% of its capacity to treat prostate cancer patients. I think all of the other proton centers all have limits to the number of prostate cancers being treated.

As the good professor describes there is a penumbra around all beams including x-ray. I wonder which one is worse. Anecdotally when I was in Loma Linda some patients, because of the concern there may be capsular escapes, were treated initially with 20 treatments protons followed by a course of 25 treatments of photons. The implication is photons were used to make sure the wider penumbra captured cancer escapes. Within a few treatments of photons there were noticeable changes in the photon patients. Physically their pallor changed to a sickly gray. Their ability to handle roughage in their diet became the cause of having to spend way to much of their day in a bathroom. Their energy level decreased.

It was so rare to meet a proton patient with one of these symptoms there must be a difference in the damage caused by photons.
PAN
Current PSA 1.2
Highest PSA 6.3
Gleason 7 (3+4)
Pre treatment PSA 4.5
Treatment Proton Therapy at Loma Linda
Blog: http://panajar.blogspot.com


John Bonneville
New Member


Date Joined Sep 2008
Total Posts : 15
   Posted 10/10/2008 11:35 PM (GMT -7)   
Yes Zietman confirms that Proton Radiation was designed for relatively superficial tumours. He raises concerns re it's accuracy in targeting deep tumours such as PCa. So far I have not found any contradictory views from academics to the Zietman position on this issue.

If Zietman's views are correct, then this information should be widely available, so as to enable informed decisions by PCa patients considering this treatment option.
Diagnosed March 2007, Age 57
Positive DRE, 12 Core Biopsy, 6 cores positive PCa,
Gleason 7 (4+3), Stage T2B
Rx 9 months LHRH ADT Lucrin, Neo Adjuvant,
Gold Seed implants 2 weeks prior to EBRT
70gy 3D Conformal EBRT

PSA: Nov 2006 = 6.0 ng/ml
May 2007 = 5.9 ng/ml * 1st Lucrin IMI
Aug 2007 = 0.85 ng/ml* 2nd Lucrin IMI
Nov 2007 = 0.45 ng/ml * 3rd Lucrin IMI
Jan 2008 = 0.29 ng/ml * 8 weeks EBRT and TURP in May
June 2008 = 0.12 ng/ml
Sept 2008 = 0.14 ng/ml

Post Edited (John Bonneville) : 10/11/2008 2:34:29 AM (GMT-6)

New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, February 18, 2018 1:27 PM (GMT -7)
There are a total of 2,930,566 posts in 321,552 threads.
View Active Threads


Who's Online
This forum has 160292 registered members. Please welcome our newest member, xjbuaa.
413 Guest(s), 10 Registered Member(s) are currently online.  Details
Storm_Rider2, L.Botev, TOOTY, Abdomare, Girlie, Saipan Paradise, Carlos, mareish, Uaunem, Tall Allen