When is PSA most likely to rise?

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Kark60
Regular Member


Date Joined Jun 2008
Total Posts : 91
   Posted 10/21/2008 8:27 PM (GMT -6)   
Does anyone know of any research that looks at when PSA is most likely to rise following RRP, if it is going to rise? In other words, if someone makes it past a year, does that make recurrence less likely? What about two years? Five years?
Husband and father of two (current ages 4 and 6).
Age when diagnosed: 47 (current)
Biopsy showed cancer only on left side.
Pre-surgery PSA: 13.7
Pre-surgery Gleason: 4+3=7
Pre-surgery Staging: T2
CT Scan, Bone Scan, PET Scan: Clear
Robotic Surgery on May 28, 2008, at Barnes Hospital in St. Louis.
Right nerve bundle spared; left bundle removed.
Catheter for 8 days with infrequent "stress" leaking. Pad-free after five weeks.
Continuing ED: attempted Viagra, Levitra, and Cialis with no response. However, had SUCCESS in October 2008 using MUSE.
POST-SURGERY PATH REPORT:
Bad news-
Gleason: 4+3=7
Involved 10% of prostate; all quadrants involved
Extraprostatic extension at left base and apex
Extensive perineurual invasion present.
Non-neoplastic prostate shows PIN, high grade, diffuse.
T3a
However, good news-
Bladder neck, lymphvasular space, seminal vesicles, 17 examined lymph nodes, and all margins are FREE of tumor.
Four-week post-surgical PSA = 0.1
Seven-week post-surgical PSA = .01
October 2008 PSA = 0.0
Next PSA scheduled for October 2008.


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 10/22/2008 6:53 AM (GMT -6)   
Most (75% if I remember right) rises are seen within the first 2 years following treatment. Rare recurrences are seen beyond 5 years however, and there always is a however....... cancer can recurr 10, even more years later. 10 years cancer free has always been thought of as the magic cure number. Guess Docs like nice even numbers.

Be Well,

Swim
 


RBinCountry
Regular Member


Date Joined Apr 2008
Total Posts : 270
   Posted 10/22/2008 7:00 AM (GMT -6)   
I attempted to purchase life insurance after my surgery, and was told to re-apply in 3 years. Usually the insurance guys know the stats so I assume the most likely period would be in the 3 year window.

I know several people here who had surgery more than 15 years ago and are still getting zeros. One man I know had his come back at the 2 year mark and had radiation. His original surgery was 18 years ago, and he is still doing great. There is a lot of hope - keep looking up!

RB

Age 61
Original data - pre-operation
PSA: 5.1
T1C clinical diagnosis, Needle biopsy - 10 cores, Gleason 7 = 3+4 in 1 core (40%), 7 cores Gleason 6 = 3+3 ranging from 5% to 12%
All scans negative
Lupron administered 4/9/2008 for 4 months (with idea I would undergo external beam radiation followed by seed implants - then I changed my mind).
Robotic DiVinci surgery - Dr. Fagin (Austin) May 19th
Post operative - pathology
pT2c NX MX
Gleason 3+4
Margins - negative
Extraprostatic extension - negative
seminal vesicle invasion - uninvolved
1st Post PSA <.04

dsmc
Regular Member


Date Joined Jul 2008
Total Posts : 149
   Posted 10/22/2008 2:04 PM (GMT -6)   
Hi Gang,
I would think it would depend on the path report. I have a friend who had RP a little over a year ago and he had a node involvement and his numbers started rising in 6 months. He has just finished his salvage RT so he said I could have his spot...lol. I just had my initial MRI this morning and see my RT Oncologist next Wed. to get Ct scan and cast set up. I am to have 7 weeks of IGRT and I sure hop it gets done before Jan. 1 for insurance purposes! As you can see by my signature my numbers were good for 3 years and are not real bad now at 0.1. At any rate I hop you have years of 0000s! RBincountry I like the numbers your friend put up after 18 years, that is very incouraging. I wish everyone the best.


David
Age 53
Pre-op PSA 4.3
Surgery Feb. 17 2005
Post-op Path : Gleason 3+3=6
Right pelvic lymph nodes: negative for metastatic carcinoma
Left pelvic lymph nodes: negative for metastatic carcinoma
extent: right lobe 40% left lobe 10%
capsular penetration: Absent
Seminal vesicles and vasa differentia: Uninvolved
Prostate: 26 grams
Post-op PSA's <0.04 for 3 years
Feb. 08: 0.07, March 08: 0.08, June 08: 0.09 and Sept. 08: 0.1
IGRT scheduled.....


aus
Regular Member


Date Joined Sep 2006
Total Posts : 211
   Posted 10/22/2008 5:22 PM (GMT -6)   

Rapid PSA rise in the first 10 months indicates metastases: ie the PC was not confined.

PSA rises that are slower and after 2 years usually suggest a local recurrence that can respond to salvage treatment.

As suggested, probabilities depend on diagnosis and surgery lab report.


lifeguyd
Veteran Member


Date Joined Jul 2006
Total Posts : 672
   Posted 10/22/2008 6:30 PM (GMT -6)   
 
This might have some data that will help you.
PSA up to 4.7 July 2006 , bump noted during DRE
Biopsy 10/16/06
T2A, Psa 4.7
Gleason  4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8
No extension or invasion found
No continence problems
PSA 90 day (-.01)  , (6 month -.01) , (9 month +.02) , (1 year +.02) ( 18 months .02)
ED still a problem, minor succces with bi-mix
urinary problems at 21 months 
 
 
 


Lungman
Regular Member


Date Joined Jan 2008
Total Posts : 276
   Posted 10/24/2008 8:51 PM (GMT -6)   
I asked the same question at my one year visit. The surgeon believes the 2 year mark is significant for the recurrence of prostate cancer, and he did mention that 10 years is the ultimate goal to have undetectable PSA's, at only one year out, this seems like an eternity!!
Randy
46 you when diagnosed, now 47
Pre-Op PSA 9.9
1 of 12 cores positive, Gleason 3+3
DaVinci on 9/5/2007
Post-Op Gleason 3+6, Negative Nodes and Margins
Less than 1% of prostate involved with CA
3 Month PSA 0.01, 6 Month PSA 0.01, 9 Month PSA 0.01
One Year PSA 0.01
Incontinence resolved 9/15/2007, one day after cath removal
ED showing significant improvement.
Cialis 5 mg every night.
Success with BiMix

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