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When is PSA most likely to rise?

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Prostate Cancer
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Kark60
Regular Member
Joined : Jun 2008
Posts : 91
Posted 10/21/2008 6:27 PM (GMT -8)
Does anyone know of any research that looks at when PSA is most likely to rise following RRP, if it is going to rise? In other words, if someone makes it past a year, does that make recurrence less likely? What about two years? Five years?
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Swimom
Veteran Member
Joined : Apr 2006
Posts : 1732
Posted 10/22/2008 4:53 AM (GMT -8)
Most (75% if I remember right) rises are seen within the first 2 years following treatment. Rare recurrences are seen beyond 5 years however, and there always is a however....... cancer can recurr 10, even more years later. 10 years cancer free has always been thought of as the magic cure number. Guess Docs like nice even numbers.

Be Well,

Swim
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RBinCountry
Regular Member
Joined : Apr 2008
Posts : 270
Posted 10/22/2008 5:00 AM (GMT -8)
I attempted to purchase life insurance after my surgery, and was told to re-apply in 3 years. Usually the insurance guys know the stats so I assume the most likely period would be in the 3 year window.

I know several people here who had surgery more than 15 years ago and are still getting zeros. One man I know had his come back at the 2 year mark and had radiation. His original surgery was 18 years ago, and he is still doing great. There is a lot of hope - keep looking up!

RB

Age 61
Original data - pre-operation
PSA: 5.1
T1C clinical diagnosis, Needle biopsy - 10 cores, Gleason 7 = 3+4 in 1 core (40%), 7 cores Gleason 6 = 3+3 ranging from 5% to 12%
All scans negative
Lupron administered 4/9/2008 for 4 months (with idea I would undergo external beam radiation followed by seed implants - then I changed my mind).
Robotic DiVinci surgery - Dr. Fagin (Austin) May 19th
Post operative - pathology
pT2c NX MX
Gleason 3+4
Margins - negative
Extraprostatic extension - negative
seminal vesicle invasion - uninvolved
1st Post PSA <.04
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dsmc
Regular Member
Joined : Jul 2008
Posts : 152
Posted 10/22/2008 12:04 PM (GMT -8)
Hi Gang,
I would think it would depend on the path report. I have a friend who had RP a little over a year ago and he had a node involvement and his numbers started rising in 6 months. He has just finished his salvage RT so he said I could have his spot...lol. I just had my initial MRI this morning and see my RT Oncologist next Wed. to get Ct scan and cast set up. I am to have 7 weeks of IGRT and I sure hop it gets done before Jan. 1 for insurance purposes! As you can see by my signature my numbers were good for 3 years and are not real bad now at 0.1. At any rate I hop you have years of 0000s! RBincountry I like the numbers your friend put up after 18 years, that is very incouraging. I wish everyone the best.


David
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aus
Regular Member
Joined : Sep 2006
Posts : 211
Posted 10/22/2008 3:22 PM (GMT -8)

Rapid PSA rise in the first 10 months indicates metastases: ie the PC was not confined.

PSA rises that are slower and after 2 years usually suggest a local recurrence that can respond to salvage treatment.

As suggested, probabilities depend on diagnosis and surgery lab report.

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lifeguyd
Veteran Member
Joined : Jul 2006
Posts : 691
Posted 10/22/2008 4:30 PM (GMT -8)
http://www.mskcc.org/mskcc/html/10088.cfm

This might have some data that will help you.

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Lungman
Regular Member
Joined : Jan 2008
Posts : 276
Posted 10/24/2008 6:51 PM (GMT -8)
I asked the same question at my one year visit. The surgeon believes the 2 year mark is significant for the recurrence of prostate cancer, and he did mention that 10 years is the ultimate goal to have undetectable PSA's, at only one year out, this seems like an eternity!!
Randy
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