I have metastases to my lungs and pelvis and am in the middle of a clinical trial. I mentioned it on another forum and was asked for more details in the hope it could help others. What follows is my post on the other forum:
The drug is made by Bristol-Myers Squibb (BMS) and is called Sprycel
(generic: dasatinib). It has proved to be almost miraculous, and is
FDA approved, for patients suffering from chronic myelogenous leukemia
(CML) and Philadelphia chromosome-positive acute lymphoblastic
leukemia and who have failed after initially doing very well on
There are only about
5,000 new diagnoses of those diseases per year,
and BMS is hoping (quite properly, I believe) that Sprycel will be
effective against solid tumors, also. On biopsy, it was discovered
that the cells in my lung nodules share an 'src' protein with the
leukemia patients. This protein aids the cells in reproducing
Currently there are a number of trials , for all kinds of cancers. My
trial has me taking two 50 mg tablets of Sprycel every day and having
infusions (iv) of the standard drugs Taxotere and Prednisone every
twenty-one days. I'm to have six infusions altogether - I had number
four last week.
Just before I had cycle number three, I had CT and bone scans which
were compared to the scans done just before I started on the meds.
The scans showed that the nodules on my lungs have been reduced in
number and many of the remaining nodules are smaller compared to the
earlier scan. The bone scan shows no change in the lesion on my
pelvis - also good news because it had grown during the period from
Feb. 2008 to June 2008.
Most of the links shown in Google for Sprycel or dasatinib relate to
CML. One of the first ones I followed was Jerry Mayfield's diary at
he suffered from CML, I was intrigued by his diary, although I admit
to not understanding all the technical terms related to his disease.
Jerry was one of the first participants in a Sprycel trial, which was
done at M.D. Anderson Cancer Center in Houston. Perhaps part of my
fascination with Jerry's account has to do with the fact that my
medical oncologist, Dr. John Araujo is also at Anderson and is, in
fact, the lead investigator of the trial in which I'm enrolled. I'd
recommend reading Jerry's diary because not only is it very well
written, I found it very uplifting and hopeful - something of which
I'm in dire need. Fortunately for me, the trial is also being done in
Nyack, New York, which is about
seventy miles from my home. It is my
understanding that these same trials are being done in many countries
around the world.
I hope this has been helpful. Feel free to ask any questions you'd
Dx PSA 26.5 Gleason 7 (4+3) @Age 611/2005
Start Casodex and Zoladex
PSA drops to <0.01 7/2005-8/2005
5 weeks of IMRT and then HDR brachy1/2007
Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT1/2007
CT scan of pelvis picks up a nodule at bottom of left lung5/2007
CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.6/2007
Thoracic surgeon removes wedge of left lung for biopsy6/2007
Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.8/2007
2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA still undetectable, but get Lupron shot to bring T down from 272/2008
Trip to Houston – PSA now 0.5 and nodules larger. Lupron shot.6/2008
Trip to Houston - Finally got results from doc. A number of lung nodules have grown, but, more important to him, is the fact that the malignant lesion on my pelvis seems to have flared up and he wants me to start chemo. He said I could wait a few months, but I told him I want to start now. He to get me signed up for a clinical trial in nearby NY.9/2008
Interim bone and CT scans show progress vs. scans done before beginning trial. I'm cautiously optimistic. Next scans 10/30/08.
Post Edited (Gordy) : 10/23/2008 6:10:02 PM (GMT-6)