How many are taking Statin drugs and still had a high PSA ?

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Regular Member

Date Joined Jun 2008
Total Posts : 440
   Posted 10/28/2008 6:13 PM (GMT -6)   
I was reading this "new" info that says Statins may lower PSA but not lower the cancer risk. Just curious as I am taking a statin but my number is not going lower it is still 1.01 and the gland is enlarged.

Veteran Member

Date Joined May 2008
Total Posts : 1010
   Posted 10/28/2008 9:40 PM (GMT -6)   


I have been taking statins for over 10 years now. Cholesterol numbers are good but PSA was up there prior to treatment. Have not had a PSA post treatment yet. I also read an article that indicated statins might improve the outcome for radiation patients. Article did not elaborate just one of those teaser lines with the "further research is indicated" disclaimer. Research never seems to reach a definitive conclusion. Unless you are a mouse. Several articles I have read indicate some treatments with very good results in mice. I had no idea that our medical profession and pharmaceutical industry were so concerned about the health of mice. I learn something new everyday. turn


Diagnosed 04/10/08
Age 58
PSA 21.5 (first and only test resulted from follow up visit to emergency room for kidney stone. first time for kidney stone too)
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear
Chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
PSA test on July 14, 08 after 8 weeks hormone .82
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
Second Lupron shot 09/11/08
Next PSA test by oncologist 03/09

Regular Member

Date Joined Dec 2007
Total Posts : 56
   Posted 10/29/2008 8:46 AM (GMT -6)   
I'd been taking statins for years before my first troublesome PSA, so in my case a PSA increase sufficient to trigger a biopsy occurred with statin use in the background (simvastatin max dose). There's obviously no way to know whether my PSA would have increased even more if I hadn't been on the statin.

Diagnosed Sep 2007 Age 54 Gleason 6 (3+3)
DaVinci Surgery 11/8/07 University of Minnesota
2/22/08, 8/15/08 PSA Undetectable

Regular Member

Date Joined Sep 2008
Total Posts : 78
   Posted 10/29/2008 2:32 PM (GMT -6)   
I too have been taking Lipitor for 5 years prior to my PSA rise.
My PSA only went up over the last two years. Related to the statin? Not likely....?
Rising PSA 12/06=1.6 12/07=2.1 5/08=2.6
Biopsy 6/4/08 Positive
Diagnose @ Age 51 Gleason 3+3=6
Bone & Cat Scans Normal
Lapro Surgery 8/18/08 at Memorial Sloan Kettering
Pathology report stage T2c organ confined with positive apical margin Gleason = 6 1/2
Catheter removed 8/26 - reinserted 8/29 - removed 9/2
No continence or potency problems.
First post op PSA 10/2/08 < 0.05

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