drb46 - First off, congratulations on no cancer found! Regarding your question "has anyone ever had increasing PSA levels and not had cancer?" I would say that "anyone ever" is possible but unimportant. Whether or not you have it is all that matters. The Prostate Cancer Research Institute web site (www.prostate-cancer.org) is a great place for research. Especially since your PSA doubling time went from 3 years to a year and a half. Finding cancer cells is much like finding the proverbial needle in a hay stack. Lots of men have more than one biopsy before finding the cancer. Lots of things besides cancer can cause elevated PSA. Work with your doctors to eliminate possible causes until you get the answer. I'm headed for my fifth biopsy this Thursday, but following a plan, not blindly repeating biopsies. Good luck.