perineural invasion (PNI) is found when the cancer cells have grown into the
openings and spaces around the perineural nerves inside the prostate. Cancer is like water, it will take the path of least resistance, and these sheaths around the nerves in the prostate gives is a good place to expand to, usually there first rather than growing outward. The nerves mentioned are in the prostate and hence the cancer is contained inside the gland, no more risk for extention to margins, etc, than any other
location inside the prostate. PNI is so common in post-surgery path. reports that a lot of pathologoists are recommending to not report it, as it is a common part of the cancer detection and diagnosis. That it was found in a biopsy core sample is unusual, but not indicitive of any more danger or typing of the cancer.
Co-Moderator- Prostate Cancer Forum
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
Present- 1 year: ED- Viagra, pump continues, no response- Trimix .10ml x 2 weekly continues
Post Surgery PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 1 Year-.02.