Trimex/Bimex Injection Pain

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TSFFZ
Regular Member


Date Joined Oct 2008
Total Posts : 25
   Posted 12/12/2008 11:54 AM (GMT -6)   
How painful are injections to address ED and how long will the erection last if successful?
 
HS

RBinCountry
Regular Member


Date Joined Apr 2008
Total Posts : 270
   Posted 12/12/2008 11:59 AM (GMT -6)   
I have been using Caverject. The injection itself is not painful at all. I use a small insulin needle. The Caverject itself works but leaves an aching pain that is not worth it. I am planning to move to Trimix, or Bimix as soon as I can find a doctor who will initiate the prescription as I understand from others that they do not have those side effects.

I would tell you to stay clear of Caverject, but not be worried about the injection itself. Once you get over the fear of sticking yourself you will find it to be almost nothing.

RB
Age 61 (now 62)
Original data - pre-operation
PSA: 5.1
T1C clinical diagnosis, Needle biopsy - 10 cores, Gleason 7 = 3+4 in 1 core (40%), 7 cores Gleason 6 = 3+3 ranging from 5% to 12%
All scans negative
Lupron administered 4/9/2008 for 4 months (with idea I would undergo external beam radiation followed by seed implants - then I changed my mind).
Robotic DiVinci surgery - Dr. Fagin (Austin) May 19th
Post operative - pathology
pT2c NX MX
Gleason 3+4
Margins - negative
Extraprostatic extension - negative
seminal vesicle invasion - uninvolved
1st Post PSA <.04
2nd Post PSA <.1 10/30/2008


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 12/12/2008 12:43 PM (GMT -6)   

Like most other guys here, my experience with Caverject in any form resulted in pain and aching, from the drug itself- not the injection.  I use Trimix 30/1/2.5 and Bimix 30/1 alternately now.  The Trimix with the Caverject level at 2.5 is ok, still very minor ache, but much better response to the med.  Bimix doesn't ache, as such, just gives a slightly warmish/full feeling, no pain or discomfort.  Whether taking any of the 3 drugs, it is a trial and error process with each, and each acts differently that the other and even from man to man, so telling you what levels to use or what your results will be won't work.  We are all individuals and react as such.  Bimix gives me just a smaller response as compared to Trimix.  The levels that I have to use Bimix (1.0 ml) to get a response compared to .35ml with Trimix is a massive dose of either to most men here.  The erection will last anywhere from an hour to 2 1/2 hours, and are usually easy to regain with manual or other stimulation, allowing for multi orgasms in those fortunate men capable of them, or at least an extended session for most.  rolleyes The injections themselves are virtually painless.  Pain usually result swhen the injection is off and you hit other parts of the penile anatomy, such as going through the cavities into the middle membrane or too close to the head, etc.  Using a 5/16 inch 31ga 1cc insulin syringe seems to be the best combination for most guys here.  There is a fear factor of putting that needle up against your penis the first time or two that must be overcome, but when you are tired of impotence and want to rehab or have functioning erections again, its a small thing and easily overcome, especially after the first good one after so many months without... turn There's several techniques to injecting and hitting the right spot in the penis, depending on the size of the penis.  Smaller and/or thinner ones take a different approach than larger ones.  There's lots of info detailing that subject here, so some reading will be in order if you decide to go the injection route. 


James C.
Co-Moderator- Prostate Cancer Forum
Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
Present- 1 year: ED- Viagra, pump continues, no response- Trimix .10ml x 2 weekly continues
Post Surgery PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 1 Year-.02.

Post Edited (James C.) : 12/12/2008 10:48:22 AM (GMT-7)


TSFFZ
Regular Member


Date Joined Oct 2008
Total Posts : 25
   Posted 12/12/2008 1:26 PM (GMT -6)   
James,
 
Thanks for the detailed and timely response.  Although you mentioned that "there's lots of info detailing that subject here, so some reading will be in order if you decide to go the injection route", I did do a search on injections, trimex, etc. and came up with zero.  I do realize that this topic hase been discussed, before, and I was frustrated in not being able to retrieve and information.  Do you have any advice regarding where/how to find it?
 
Thanks, TSFFZ 

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 12/12/2008 2:15 PM (GMT -6)   
 
Here's some of my saved items dealing with the subject, in no particular order.  Ask further questions, someone will have the answer, I hope....
James C.
Co-Moderator- Prostate Cancer Forum
Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
Present- 1 year: ED- Viagra, pump continues, no response- Trimix ..35ml x 2 weekly continues
Post Surgery PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 1 Year-.02.


TSFFZ
Regular Member


Date Joined Oct 2008
Total Posts : 25
   Posted 12/12/2008 2:36 PM (GMT -6)   
Thanks!

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 12/12/2008 2:43 PM (GMT -6)   
part of the problem with your failed search may have been the spelling- both are mix, not mex....trimix, bimix tongue
James C.
Co-Moderator- Prostate Cancer Forum
Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
Present- 1 year: ED- Viagra, pump continues, no response- Trimix ..35ml x 2 weekly continues
Post Surgery PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 1 Year-.02.


TSFFZ
Regular Member


Date Joined Oct 2008
Total Posts : 25
   Posted 12/12/2008 3:26 PM (GMT -6)   
My search function appears to be compromised; I just did a new search for trimix over the last year and only received your last post.

Thanks, again, for all of the helpful links

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 12/12/2008 6:24 PM (GMT -6)   
There are two search functions on this site:

1. The one that reads "... | Chat | Search | Members ..." etc. in the blue title bar near the top of these pages. I have found this to give poor results.

2. The Google Custom Search just above that with the grey "Search Site" button. This gives much better results.

Bimix and Trimix are much cheaper than the Caverject -- another reason to avoid Caverject. I use Bimix, 0.2ml per shot. I use a 27g needle, and usually feel a little discomfort at the time of injection. My wife does the shot -- doesn't hurt her a bit. :-) An essential element for me is some constriction at shot time and for at least 2 minutes after -- I use two 2" diameter rubber bands each doubled over.
Age 63. Other than cancer, in good health; BMI 20
Pre-op: No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores
7 March 2008, RRP, non nerve sparing
Two nights in hospital; catheter and staples out after 7 days
Continent, no pads needed from the get-go
Post Op: Stage pT2 M- N-; clear margins and lymph nodes; Gleason 4+4=8; prostate weight: 37gm
6-week and 7-month PSAs: 0
Bimix injections working well 


TSFFZ
Regular Member


Date Joined Oct 2008
Total Posts : 25
   Posted 12/13/2008 12:26 AM (GMT -6)   
Thanks, that works MUCH better!

mvesr
Veteran Member


Date Joined Apr 2007
Total Posts : 823
   Posted 12/13/2008 10:41 AM (GMT -6)   
TSFFZ

I had my first shot almost two weeks ago. It hurt a little bit but what a wonderful result. It lasted a couple of hours with no problems. I thought I was a kid again. I don't know what was in the shot but the Dr used an insulin needle. I am going back for an education session with the Dr. and I am anxious about getting started.

Mika
age at dx 54 now 56
psa at dx 4.3
got the bad news 1/29/07
open surgery Duke Medical Center 5-29-07
never more than 2 pads
Tossed the pads this spring
ED still a problem
Got a shot last week and it was great
A year an a half of zero's
 


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 12/13/2008 11:02 PM (GMT -6)   
Trimix works really well for me. It took a while to get the dose right (different for everyone) and get used to using the syringe (all thumbs here). The doc started me with .10 ml and it was waaay too much because it lasted too long and ached a lot. I now use .03 - .05 ml along with 50 mg Viagra and it lasts about an hour, comes up multiple times and doesn't hurt at all. Almost like being 21 again except I'm too short winded to take full advantage...

Jim
Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 7/17/08 0.00. 
Next PSA test on 1/28/09
Lung cancer dxed on 5/16/08.  Surgery on 6/25/08  T1N1M0 - Stage IIA  Finished 4 cycles of chemo on 11/7/08.
CT scan on 12/2/08 - in remission!!!
Next scan on 2/26/09.
"Patience is essential, attitude is everything."

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