Clinical Trial - Abiraterone

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

War-eagle
Regular Member


Date Joined Sep 2007
Total Posts : 219
   Posted 12/13/2008 12:39 PM (GMT -6)   
I wanted to start this new post to keep everyone up to date on the trial.
I started taking the drug or placibo and prednisone (10mg) on 12/2/2008.
A gentlemen that is on the trial and that is 3 months ahead of me has seen his PSA drop from 98 to .3. He IS on the drug. He is having only hot flashes as any side effect.
 
I will wait to make any decisions on future care or a continuation of the trial only when I have completed 2 months.
On 11/13/2009 my PSA was 9.25
On 11/18/2008 my PSA was 10.9
On 12/2/2008 my PSA was 13.78 Started trial drugs.
On 12/11/2008 my PSA was 16.94
I have been off casodex for over 6 weeks, so this may be the reason for the increase.
 
Right now it doesn't look like I am getting the drug, but I will be patient.
 
If anyone has any questions, please contact me by e-mail or post here. This trial is for all of us. Drug or placibo someone has to do it. If not me, then who?  We are all in this fight together. As I told Tony once, There is no I in team, but there are 2 off them in idiot. Only an idiot goes it alone.
 
Go speed and love to all.
 
War Eagle, Baby.
 
Walt (waltwhited@aol.com)
Age: 55 ( still alive at 55)
PSA 43 7/2005
Biopsy 12/14 Gleason 7 & 9
Divinci 9/2005 - spread to bladder
HT - 10/2005 (Eligard every 6 months)
RT - 10/2005 (38 treatments)
PSA 0.12 to 1.9 2/2007
Bone Scan and CT 4/2007 Bone mets
Casodex 4/2007
Zometa infusions 4/2007
PSA 4.8 8/2007
PSA 6.34 12/2007
Radiation (15 treatments) started on bone mets 12/2007
PSA 6.72 1/2008
PSA 8.23 2/2008 - Starting prednisone for 30 days
PSA 14 2-29-2008 - start chemo on 3/12
PSA 12.82 3/1/2008 round one chemo
PSA 12.24 4/2/2008 round two chemo 
PSA 10.86 4/24/2008 round three chemo
PSA 10.4 5/15/2008 round four chemo - increase dosage next month
PSA 12.98 6/5/2008 round five chemo
PSA 13.63 6/26/2008 round six chemo
PSA 10.46 7/17/2008 no chemo
PSA 4.56 8/28/2008 no chemo, Zometa and 6 month Eligard shot
PSA 9.25 12/1/2008 start clinical trial
PSA 16.94 12/11/2008
 
"I will persist without exception - I will find a way where there is no way"


Todd1963
Veteran Member


Date Joined Oct 2008
Total Posts : 3218
   Posted 12/13/2008 12:52 PM (GMT -6)   
Is this a phase III trial. Is the trial still open. Is this the trial that you have to fail chemo before being eligible. alt I pray that you will be getting the drug. I pray for a drop in psa. You are a mighty war-eagle.
dx:06/03/06
Age at dx: 42 age now 45
Treated for sciatic nerve pain 6 months prior to dx.
Heavy amount of blood in urine Unable to urinate 
Lung x-ray for pnumonia revealed multiple lesions in each lung
P.S.A. at time of dx. 3216.14
Began lupron and casodex
Cat scan showed large mass in the pelvic area affecting the bladder multiple nodules in both lungs and lymph node envolvement.
Bone scan revealed possible bone involvment in the pelvic area
Biopsy 12 of 12 cores positive gleason 3+4=7
P.S.A.s since lupron 2946, 1274, 532, 5.01 1.23, .09
Begining jan 08 psa .o9, .25, .44, .86, .73, 1.34, 1.49. Doubling time is a little over 3 months


BillSD
Regular Member


Date Joined Sep 2008
Total Posts : 143
   Posted 12/13/2008 12:53 PM (GMT -6)   

Walt,

It's great to hear you are on the trial. I have been following the news releases on this drug's trials for six months and it is the most promising prostate cancer advance "in 70 years" according to the experts.

I appreciate the attitude that you are in the trial for all of us, and we salute you.

Does the War Eagle moniker mean you are from Auburn? One of my four favorite SEC schools (along with MSU, UK and Vandy).

Best to you, and thanks for keeping us posted.

Bill in San Diego


Age 59 at diagnosis (Now 60)
PSA 4.4
05/15/2008 – Biopsy
Gleason 3+3=6
Most cores positive 40% or more, some 100%
Bone scan and pelvic/abdomen CT show no visible metastasis
06/15/2008 – Began two months Casodex 50 mg
07/01/2008 – Trelstar shot (3 month dose)
09/15/2008 – Retropubic Radical Prostatectomy
Pathology: Staging pT2c pN0 MX
Gleason post op: 3+4=7
No discrete tumor mass
Bilateral involvement
No capsular penetration (carcinoma extends into but not through capsule bilaterally)
Perineural tumor invasion (PNI): present
Perineural margin: Free of carcinoma
Bladder neck: Free of carcinoma
Distal (Urethral) Margin: Carcinoma present
Seminal Vesical: None present
Lymph Nodes: 18 nodes free of metastatic carcinoma
10/13/2008 - PSA <0.1 - disclaimer: I had HT, so...
12/01/08 - Begin 35 treatments EBRT (adjuvant radiation because of concern for positive distal margin and PNI)
 
 
 


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 12/13/2008 3:00 PM (GMT -6)   
Hi Walt!
Great way to start the day, you sounded great. We have some work to do, but I am a proud member of your team. And looking at the wonderful support you are offerred, you are on a great team.

Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (September 17 '08): <0.1 ~ Undetectable!
 
You can visit my Journey at:
 
STAY POSITIVE!
 
 


FLHW(David E)
Regular Member


Date Joined Nov 2007
Total Posts : 201
   Posted 12/14/2008 4:38 PM (GMT -6)   
Walt, way to go to war for all of us, we're praying you're getting the drug and not the placebo!
Dx'd 2/18/05
PSA 271, bone mets, lymph node involvement
Gleason Score: 7
Current (11-24-08)
PSA: 39.97
Taxotere + Prednisone + Atrasentan
[9th Treatment on November 24th]
Clinical Trial:
http://www.clinicaltrials.gov/ct2/show/NCT00134056?term=prostate+AND+atrasentan&rank=2
Lupron
Personal Blog:
prostatecancerat42.blogspot.com


Rolerbe
Regular Member


Date Joined Dec 2008
Total Posts : 235
   Posted 12/14/2008 9:06 PM (GMT -6)   
Walt,

Thanks for paving the way for all of us. I hope you get great results.
50 YO
PSA at Dx: 8.2
DaVinci RALP: 10/31/08
Negative margins, no extra-capsular involvement
One nerve spared
No follow-up PSA yet (next week).
 


livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 12/15/2008 7:02 AM (GMT -6)   
We are on your team Walt just remember we need are captain healthy and fighting so keep those spirits high. You are an awesome person and I am proud to call you friend.

peace and love
Dale
My PSA at diagnosis was 16.3
age 46 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes was 4+4=8
I had 44 IMRT's
Casodex
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11
PSA July 24th, 2008 is 0.04
cancer in 4 of 6 cores
92%
80%
37%
28%
 


War-eagle
Regular Member


Date Joined Sep 2007
Total Posts : 219
   Posted 12/15/2008 4:56 PM (GMT -6)   

Just to answer a few of the questions.

Yes this is a phase III trial and you must have failed at chemo. There are around 1280 test subjects for this trial. I got lucky. I do believe there are spaces still available. It's nice to get a reward for failing at something.

The War Eagle does mean Auburn University. War Eagle is our Battle Cry. It has served me well over the years. A great school and really great people. So many traditions like the battle cry. We have Tiger Walk at games and an eagle is released from the upper deck before kickoff. After flying above the stadium, it lands at mid-field. We have two eagles. A bald eagle and a golden eagle. This re-creates the story of where the battle cry came from. A wonderful story. We have many names, Plainmen, War Eagle, and the offical name, Tigers.

I don't live in Auburn. I live in Trussville, just outside Birmingham.

The fight goes on. WAR EAGLE!

Walt


Age: 55 ( still alive at 55)
PSA 43 7/2005
Biopsy 12/14 Gleason 7 & 9
Divinci 9/2005 - spread to bladder
HT - 10/2005 (Eligard every 6 months)
RT - 10/2005 (38 treatments)
PSA 0.12 to 1.9 2/2007
Bone Scan and CT 4/2007 Bone mets
Casodex 4/2007
Zometa infusions 4/2007
PSA 4.8 8/2007
PSA 6.34 12/2007
Radiation (15 treatments) started on bone mets 12/2007
PSA 6.72 1/2008
PSA 8.23 2/2008 - Starting prednisone for 30 days
PSA 14 2-29-2008 - start chemo on 3/12
PSA 12.82 3/1/2008 round one chemo
PSA 12.24 4/2/2008 round two chemo 
PSA 10.86 4/24/2008 round three chemo
PSA 10.4 5/15/2008 round four chemo - increase dosage next month
PSA 12.98 6/5/2008 round five chemo
PSA 13.63 6/26/2008 round six chemo
PSA 10.46 7/17/2008 no chemo
PSA 4.56 8/28/2008 no chemo, Zometa and 6 month Eligard shot
PSA 9.25 12/1/2008 start clinical trial
PSA 16.94 12/11/2008
 
"I will persist without exception - I will find a way where there is no way"


Todd1963
Veteran Member


Date Joined Oct 2008
Total Posts : 3218
   Posted 12/15/2008 6:23 PM (GMT -6)   
Walt, I am replying to you on this post cuz its yours. Thank you so much. It is so good to have others around to help carry the burden when we are weak. I would love to sit down and have a heart to heart with you some time. My E-mail woodandwire63@yahoo.com I use this e-mail only for this site. we can exchange our digits if you want and yack on the phone. I have so many female hormones I can talk for hours. Todd

dx:06/03/06
Age at dx: 42 age now 45
Treated for sciatic nerve pain 6 months prior to dx.
Heavy amount of blood in urine Unable to urinate 
Lung x-ray for pnumonia revealed multiple lesions in each lung
P.S.A. at time of dx. 3216.14
Began lupron and casodex
Cat scan showed large mass in the pelvic area affecting the bladder multiple nodules in both lungs and lymph node envolvement.
Bone scan revealed possible bone involvment in the pelvic area
Biopsy 12 of 12 cores positive gleason 3+4=7
P.S.A.s since lupron 2946, 1274, 532, 5.01 1.23, .09
Begining jan 08 psa .o9, .25, .44, .86, .73, 1.34, 1.49. Doubling time is a little over 3 months

New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, July 17, 2018 8:21 PM (GMT -6)
There are a total of 2,982,584 posts in 327,019 threads.
View Active Threads


Who's Online
This forum has 161838 registered members. Please welcome our newest member, wnd03572.
417 Guest(s), 6 Registered Member(s) are currently online.  Details
Froggy88, mysweetpanda, masonbor, OriolCarol, fjdrill, borborygmi