There are 18 variants (types) of PCa-link to web information

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Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 12/31/2008 7:35 PM (GMT -6)   
In case people thought there was only one type, the prognosis for some of this variants which can be rare cases, can be bleak in comparison to what most of us face. Good pathology should be able to define which type you have, another reason for possible reviews by experts (Bostwick, Epstein, Oppenheimer etc.)
I have seen a few people who got diagnosed with small cell PCa, it is so sad I won't talk about right now.
Kind of gives you a better perspective cause it shows photo/slides of what pathologists look at, it is an art to define, what, where- like as to perineural invasions, Gleason scoring, percentages found etc.
Interesting to know even a little on this stuff.

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 12/31/2008 7:39 PM (GMT -6)   
I have heard that sarcoma of the prostate is far more aggresive than adenocarcinoma. In fact I have met a couple guys with the former. They had a poor prognisis and my understanding that the PSA does not necessarily rise with it. Thanks for the link, Bob.

Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (September 17 '08): <0.1 ~ Undetectable!
You can visit my Journey at:

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 12/31/2008 7:46 PM (GMT -6)   
Hi Tony and congrat on moderator status, I didn't know about the scarcoma of the prostate cases, I have heard that some very aggresive PCa's (high end Gleasons no doubt included) can give off little or no PSA's, so another exception to the PSA monitoring can exist and this one would be scary to find out the hard way about where you stand with PCa in your body, this is why other markers are needed. Folks that are very high risk, high stats, should be under the care of oncology doctors and not uro-docs because of level of expertise that could make a difference to you the patient.
"Youth is wasted on the young"-W.C. Fields
"I wouldn't join a club that would have me as a member"-Groucho Marx

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