Pathology information and basics from the experts-websites via Google

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Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 1/4/2009 8:29 AM (GMT -6)   
You can google sites and find great information about pathology for a quick lessons in terminology and meanings. Do you know what diploid DNA structures in cells is about(plodity testing in other words??), perinueral invasion, high grade PIN vs. PIN  Differentiated cells, variant types of PCa., do you know how the methodology-science of this is done????
The experts (there are some others):  Bostwick  (Bostwick Labs), Oppenheimer, Epstein
Bostwick and Oppenheimer I know have good information, also you may to contact such folks for expert review on your pathology, which is not stupid or a waste of your money for many people anyway. Insurance may or may not cover 2nd opinion on slides, it is probably worth the expense to you to know more definitively what grade or variant of PCa you might actually have, there are atleast 18 PCa types, the average pathologist is not comparitive to these experts is the bottom line. Upon reviews many times the local pathologist got it with less accuracy.
I met Bostwick at a PCa support group once, this guy is not faking his passion for PCa, he spoke for about 1-hour and you can see, feel, and darn near touch his passion for this, and probably that is why he is so darn good at what he does. Probably the other experts are under this same passion for their work and reputations. Don't want to seemed over biased, they  not are given acolades for their mug shots.
Keep on rockin in the free world   (Neil Young if like rock n roll) :-)

Post Edited (zufus) : 1/4/2009 8:44:26 AM (GMT-7)

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 1/4/2009 8:33 AM (GMT -6)   
Hey thanks for the tip about editiing.

Post Edited (zufus) : 1/4/2009 8:40:03 AM (GMT-7)

Steve n Dallas
Veteran Member

Date Joined Mar 2008
Total Posts : 4848
   Posted 1/4/2009 8:45 AM (GMT -6)   
Look in the upper right corner in your post for the PENCIL/edit button...
Age 53   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Gleason - 6
(biopsy done March 4, 2008-> 2 of 12)
06/25/08 - Da Vinci robotic laparoscopy
10/03/08 - 1st Quarter PSA -> less then .01

Surgeon - Keith A. Waguespack, M.D.

Las Colinas and Plano Offices


Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 1/5/2009 2:28 AM (GMT -6)   
Hi Bob,
Bostwick, Oppenheimer and Epstein are the big three for prostate cancer. I have not met any of them but Epstein did review my surgical pathology findings...He didn't have any findings that made matters worse, or better.

"They are what we think they are!" Dennis Green, former NFL coach...LOL, do you guys in Detroit still watch football? I can understand if not after the seasons the Lions, Spartans, and Wolverines just had.

Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (September 17 '08): <0.1 ~ Undetectable!
You can visit my Journey at:

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 1/5/2009 5:45 AM (GMT -6)   
Well that was very wise to have it reviewed especially for patients whom chose one time treatment modalities towards cures. Many times when reviewed by experts pathology reveals all kinds of things that were missed (evidence is out there on such), with 18 types of prostate cancer it is very possible to not even know which one a patient actually has(it is an art and you need an artist), let alone the many other variables. Because of Partin tables, Narayan, Bluestein, nomograms and mathematical 'gigs' we take this pathology and other known numbers (psa, gland volume/size, etc. stuff) and put them into those models to seek out a possible clue as to where does one fall in the percentages or odds of the average patient who under goes certain modality/treatments. It is an averages thing you end up looking at, some would end up on either side (above or below), it is not precise science, but is used as a possible tool in PCa for consideration and has some merit. Then patients and doctors can use this type of information to make hopefully a better decision as to how to treat PCa, or atleast have a small clue as to risk and reward concept for a treatment modality.

There are actually 3 kinds of ploidity that can be found by pathology, why even bother to know???? (I believe it is something like this): The first being diploid DNA (double stranded-close to normal cell structures) responds best to hormone drugs, aneuploid (might have been like triple stranded-not quite as well for response) and a third one can't remember if it was called tetraraploid?(way crazy DNA structures-anyway it is the worst diploidity) to have and probably the patient would have a heads up knowing what they may be facing as to taking drug therapies against it (treatment risks)and/or possible survival time. I don't have my notes in front of me...but those three explained (lightly) is the guts of the matter, it is probably great my memory is even this good after seeing this stuff 6 yrs. ago or so. Not everyone needs to know their ploidity on pathology, but experts can test for such (it is additional costs) and you probably did not get this information in the original pathology that was sent out to a lab.

Now football- Lions are probably the best 'high school' team out there (LOL). Perfect season (hooray). Myself I enjoy a close game and don't get to excited about being numeral uno and I even praise Ohio State against our two Michigan teams. If your good it is worth a watch. O-how-I hate-Ohio State (not my mantra-isn't that silly to tout out in public????) I admire good teams, luckily I did not get biased by going to MSU or M-State (my brothers went their) but they don't real care who wins anyway.
One brother has PCa for 4 yrs.+ now and doing w.w.(monitoring), the other appears clear via testing and psa's at this time, my father is unknown never diagnosed that we heard of and died of a stroke issues. My sister is the oldest and has no major medical issues we know of at this time.
Like Arnold S.-  "I'll be back"


Post Edited (zufus) : 1/5/2009 4:09:12 AM (GMT-7)

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