The book that DD mentions addresses metastatic disease that is hormone refractory. The drugs that Dr Myer's book mentions as second line therapy are as follows:
Ketoconazole, has some issues with it's use but don't most of them?
Diethylstilbestrol (DES), cardiovascular side effects that are manageable but do need to be considered.
Sandostatin, an anti growth hormone agent. Dr. M. sites a study where a similar drug and dexamethasone, a steroid, had a positive effect and side effects were low. Study was at the University of Athens.
Leukine, used to improve white blood cell count, according to Dr M. leukine was used 14 days out of every 28 and arrested or slowed the progression of the disease. An interesting side effect was that the protocol seemed to reverse intestinal damage due to radiation and reversed coronary artery disease.
I would suggest that you research these on the net and also ask your consultant about them and the proper use. If he is unwilling to investigate the use in your husband's case find another consultant who will.
Miss Julia, I sincerely hope that you and your husband are able to find further assistance.
Best of luck to you both.
PSA 21.5 (first and only test resulted from follow up visit to emergency room for kidney stone. first time for kidney stone too)
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear
Chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
PSA test on July 14, 08 after 8 weeks hormone .82
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
Second Lupron shot 09/11/08
Next PSA test by oncologist 03/09