I Need Help With TriMix

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FarEvrYng
New Member


Date Joined Dec 2007
Total Posts : 12
   Posted 1/18/2009 9:15 PM (GMT -6)   

I have been using trimix for a year.  During this year I have tried several different mixtures (30-1-20   20-1-10   15-0.5-10) and have always used from .04 cc/ml to .08 cc/ml.  I have made it to the ER three times.  While using the lowest mixture and injecting .06 to .07 cc/ml erections have been around the 85% mark for 5 to 10 minutes then dropping rapidly to the 35% mark and staying at this point for 5 to 7 hours even after 2 to 4 “real” Sudafed and ice.   I have tried .04 cc/ml and 50 mg Viagra with the same results.

 

Does anyone have any suggestions as to what I might try next?  Am I one of the chosen few that injections of any kind are not going to help?

 

Thanks for suggestions, comments or sharing your similar experiences.

 

Gary in MS


07/02/07  Diagnosed PSA 7.00  Gleason 6
07/03/07  Happy Birthday (59)
10/03/07  Robotic Laparpscopic Prostatectomy             
12/17/07  PSA 0.05
01/07/08  First TriMix Injection
02/08/08  Pad Free
03/20/08  PSA 0.05


BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 1/18/2009 10:22 PM (GMT -6)   
FarEvrYng,
Many members have reported troubles and pain with Tri mix and have opted for the Bi-mix formulation that leaves out the ingredient that causes the problems but is still just as effective. Some who are currently using this approach will undoubtably let you know the finer details.
Bill
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07
4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable
PSA April 08 <0.001 undetectable (disregarded due to lab "misreporting")
PSA August 08 <0.001 undetectable (disregarded due to lab "misreporting")
Post-op pathology rechecked by new lab:
Gleason downgraded to 4+3=7
Focal extension comprised of grade 3 cells
PSA September 08 <0.01 (new lab)

Post Edited (BillyMac) : 1/18/2009 11:22:52 PM (GMT-7)


apacker1950
Regular Member


Date Joined Nov 2008
Total Posts : 122
   Posted 1/18/2009 11:32 PM (GMT -6)   
I have been using trimix for nearly 3 years now with very good results.  My formula is  (according to the RX on the bottle) alprostadyl - 5.88mcg, papaverine 17.64 mg, phentolamine .588ml.  I don't know if it is mixed with saline or something else, but I end up with 50 ml of mixture.  My dosage is usually around 1.1ml and is good for well over an hour, sometimes over 2 hours.  I may have my Dr. prescribe bimix on my next round to see if it works for me because trimix does cause a little aching once in awhile.  I hope this info will be helpful.   Allan
 
 
Age 54 at Dx.   Currently 58
Jly 05- PSA 8.1
Sept 05- PSA 10.7
Sept 05- Biopsy revealed 9 of 12 cancerous, Gleason 3+3=6, T2 stage
Bone scan and cat scan showed hot spot on hip bone.
Oct 05- Surgery for bone biopsy.  Pathology showed benign growth, no cancer in bones. Who ever thought I would be happy to only have PCa?
Nov 05- PSA 15.4
Nov 18, 05- Nerve sparing open RP at Huntsman Cancer Center, SLC, UT by Dr. Robert Stevenson. 
Home after 3 days.Cath out at 2 wks.
Incontinence gradually improved for about 3 months to 100% continence.
ED- Tried the big 3 pills with no results
Feb 06- PSA undetectable, Started VED which worked but caused discomfort with constriction rings.
May 06- PSA undetectable, Dr. gave me an Rx for Trimx injections. They work great.  Still use VED on off days without constriction for therapy.
Aug 06- PSA undetectable 
Nov 06, May 07, Nov 07, May 08, Nov 08 - PSA undetectable
ED appears to be perminant but doing great with Trimix.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/19/2009 12:42 PM (GMT -6)   
Gary, I had written Trimix (and Bimix) off as ineffective to me. I then tried a little trick that has made a vast improvement in the effectiveness of both. I found that I was missing the mark most of the time, or when hitting it, the drug flowed out of my body before adsorbing into the tissue. I use the following method now, and it is a sure-fire winner for me. Using a VED (penis pump) and rings, I pump the penis up about 15 to 20%, just enough to fill the cavities with some blood. I then roll the ring off the pump onto my penis (the smallest ring I have) and then inject myself. When I inject , I can feel the needle passing thru the outer tissue and dropping into the cavity (It sounds worse than it feels). The resistance falls as soon as I get the neddle point into the cavity. Added benefit is I have no pain- repeat no pain from the injection now, versus quite a bit before. I then inject, then gently massage the penis -very gently-- to spread the drug around inside. After around 3 minutes, I remove the ring and go ahead with foreplay. This method results in a useable erection every time, lasts from 1 to 2 hours, and not a failure since I started. The veinous valves in my penis aren't functioning yet, so keeping the drug inside until it can adsorb is what I need. Using this method I have dropped by usage of Trimix from .3cc to .1cc and Bimix from .5cc to .2cc. I suggest you try this method. If you don't have a pump, get some rings and an applicator- around 20 bucks online- and manually milk the penis to get blood into it, until it becomes plump, then apply the ring. Can't hurt and might help-worth a try? If you do try this method, inject only half or less of what you were using, and keep trying until you find a formula that works the most.
James C. Age 61
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/07 Nerve sparing open Retropubic Radical Prostatectomy
9/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 12 mts.-.02, 16mts.-?


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/19/2009 12:46 PM (GMT -6)   
Allan, I just asked a pharmacist at Francks about the ratios. The 30/1/10mcg is the amount of drugs in 1ml of sterile bacteriostatic water. If you get 5ml (you said 50ml- is that right?) then you got 30/1/20 x 5 times ther individual drugs in the vial. I hope you meant you get a 5ml vial and inject .11ml/cc per injection. The 1.1 ml size is massive for Trimix, I think.
James C. Age 61
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/07 Nerve sparing open Retropubic Radical Prostatectomy
9/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 12 mts.-.02, 16mts.-?


apacker1950
Regular Member


Date Joined Nov 2008
Total Posts : 122
   Posted 1/19/2009 12:53 PM (GMT -6)   
James,  Thanks for the clarification. I had never paid much attention to the formula... just new that it worked.  Have a great day.  Allan

Age 54 at Dx.   Currently 58
Jly 05- PSA 8.1
Sept 05- PSA 10.7
Sept 05- Biopsy revealed 9 of 12 cancerous, Gleason 3+3=6, T2 stage
Bone scan and cat scan showed hot spot on hip bone.
Oct 05- Surgery for bone biopsy.  Pathology showed benign growth, no cancer in bones. Who ever thought I would be happy to only have PCa?
Nov 05- PSA 15.4
Nov 18, 05- Nerve sparing open RP at Huntsman Cancer Center, SLC, UT by Dr. Robert Stevenson. 
Home after 3 days.Cath out at 2 wks.
Incontinence gradually improved for about 3 months to 100% continence.
ED- Tried the big 3 pills with no results
Feb 06- PSA undetectable, Started VED which worked but caused discomfort with constriction rings.
May 06- PSA undetectable, Dr. gave me an Rx for Trimx injections. They work great.  Still use VED on off days without constriction for therapy.
Aug 06- PSA undetectable 
Nov 06, May 07, Nov 07, May 08, Nov 08 - PSA undetectable
ED appears to be perminant but doing great with Trimix.


apacker1950
Regular Member


Date Joined Nov 2008
Total Posts : 122
   Posted 1/19/2009 12:56 PM (GMT -6)   
James, And yes, the dose is .11. That was a fairly important typo. Thanks again, Allan
Age 54 at Dx.   Currently 58
Jly 05- PSA 8.1
Sept 05- PSA 10.7
Sept 05- Biopsy revealed 9 of 12 cancerous, Gleason 3+3=6, T2 stage
Bone scan and cat scan showed hot spot on hip bone.
Oct 05- Surgery for bone biopsy.  Pathology showed benign growth, no cancer in bones. Who ever thought I would be happy to only have PCa?
Nov 05- PSA 15.4
Nov 18, 05- Nerve sparing open RP at Huntsman Cancer Center, SLC, UT by Dr. Robert Stevenson. 
Home after 3 days.Cath out at 2 wks.
Incontinence gradually improved for about 3 months to 100% continence.
ED- Tried the big 3 pills with no results
Feb 06- PSA undetectable, Started VED which worked but caused discomfort with constriction rings.
May 06- PSA undetectable, Dr. gave me an Rx for Trimx injections. They work great.  Still use VED on off days without constriction for therapy.
Aug 06- PSA undetectable 
Nov 06, May 07, Nov 07, May 08, Nov 08 - PSA undetectable
ED appears to be perminant but doing great with Trimix.


FarEvrYng
New Member


Date Joined Dec 2007
Total Posts : 12
   Posted 1/19/2009 1:04 PM (GMT -6)   
Thanks for the responses.  I will give the pump and ring a try.  However, my main proplem has not been obtaining and errection, but getting rid of it in 2 to 4 hours instead of 5 to 7 hours.

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/19/2009 1:10 PM (GMT -6)   
Well, I misunderstood what you were talking about then... tongue The only remedy I know for overstaying erections is Sudafed and long winters night walks- from personal experience that is..lol Maybe with the rings deal and using less, you will get better effect and less after effect?
James C. Age 61
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/07 Nerve sparing open Retropubic Radical Prostatectomy
9/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: 3 mts-.04, 6 mts.-.04, 9 mts.-.04, 12 mts.-.02, 16mts.-?


hb2006
Regular Member


Date Joined Nov 2008
Total Posts : 299
   Posted 1/19/2009 9:32 PM (GMT -6)   
I have found that a hot bath for an hour or two will bring it down along with having your legs raised above the rest of your body while in the tub. I'm taking 25 mcgs of Edex/Caverject which works in 10 minutes but can last for 3+ hours. Then I'm also taking Motrin or Advil to kill the pain from the alprostadil.

lifeguyd
Veteran Member


Date Joined Jul 2006
Total Posts : 686
   Posted 1/20/2009 1:34 AM (GMT -6)   
FarEvrYng said...

I have been using trimix for a year.  During this year I have tried several different mixtures (30-1-20   20-1-10   15-0.5-10) and have always used from .04 cc/ml to .08 cc/ml.  I have made it to the ER three times.  While using the lowest mixture and injecting .06 to .07 cc/ml erections have been around the 85% mark for 5 to 10 minutes then dropping rapidly to the 35% mark and staying at this point for 5 to 7 hours even after 2 to 4 “real” Sudafed and ice.   I have tried .04 cc/ml and 50 mg Viagra with the same results.

 

Does anyone have any suggestions as to what I might try next?  Am I one of the chosen few that injections of any kind are not going to help?

 

Thanks for suggestions, comments or sharing your similar experiences.

 

Gary in MS

Hi Gary
Correct me if I am wrong, but your concern is that your erections last too long using tri-mix.  Is that right?
 
 You say that you have a 35% erection for 5 to 7 hours, as far as I know that is not a problem.  With bi-mix some of my erections last nearly that long, but are usually 50% or less.  My urologist said that was ok.  The problems start when you have a rock hard erection that lasts for over 4 hours, a lesser erection should not be considered a problem. (If I am wrong medically,someone please tell me)
 
If that is where you are, and if it checks out with your doc, you shouldn't have to worry.  Sounds like the shots are working for you.
PSA up to 4.7 July 2006 , nodule noted during DRE
Biopsy 10/16/06 ,stageT2A
Aggressive Gleason 4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8
No extension or invasion identified
Few continence problems
PSA 90 day (-.01)  , (6 month -.01) , (9 month +.02) , (1 year +.02) ( 18 months +.02) (two years+.02)
One side nerve spared
success but some plaque with bimix 
born in 1941


RBinCountry
Regular Member


Date Joined Apr 2008
Total Posts : 270
   Posted 1/20/2009 4:32 PM (GMT -6)   
I am appreciative of the information provided - the experiences of various persons. I too am wrestling with Trimix and pain. The aching I have experienced is not just from a full erection. As time goes on it continues even with partial. For me the pain is so significant that unless the right combination is found it is simply not worth it. It is the kind of thing that would be humorous were it not so painful - it is from one extreme to the other.

I am having a difficult time understanding why the doctors want to use alprostadyl knowing that it is the pain producer for some of us. It appears that Bimix without the alprostadyl works for most effectively without the pain. At any rate, I am going to try what James C has described with a lesser dose and see what occurs.

RB
Age 61 (now 62)
Original data - pre-operation
PSA: 5.1
T1C clinical diagnosis, Needle biopsy - 10 cores, Gleason 7 = 3+4 in 1 core (40%), 7 cores Gleason 6 = 3+3 ranging from 5% to 12%
All scans negative
Lupron administered 4/9/2008 for 4 months (with idea I would undergo external beam radiation followed by seed implants - then I changed my mind).
Robotic DiVinci surgery - Dr. Fagin (Austin) May 19th
Post operative - pathology
pT2c NX MX
Gleason 3+4
Margins - negative
Extraprostatic extension - negative
seminal vesicle invasion - uninvolved
1st Post PSA <.04
2nd Post PSA <.1 10/30/2008


FarEvrYng
New Member


Date Joined Dec 2007
Total Posts : 12
   Posted 1/20/2009 8:12 PM (GMT -6)   
Lifeguyd...  Thanks for your response.  I talked to the urologist last week and he said the same thing about the "50%" erections.  I feel much more comfortable hearing something from someone this forum than from the doc.  I was thinking that when someone mentioned the duration of an erection that it meant until flacid.  After some of my past experiences it is difficult to go to sleep knowing I am still at 35%.  I definately do not want anymore damage.
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