In case you didn't know men and women already have both testostorone and estrogen in the bodies naturally. Adrenal glands make some of this testostorone for women. Both PCa and Breast Cancer have alot of commonality in hormone related control and such.
Estrogen is actually highly effective against PCa and the side effects are not as bad as people might think. The benefit of using such especially in advanced patients is it can work when traditional hormone therapies are failing, it also has pluses for bone density and memory compared to LHRH drugs which deplete those (longer useage of them perhaps). I know of patients in the USA whom have done this with Climara patch or Vivelle or other name brands. You do not have the hot flashes, weight gain, fatigue....like you do on ADT1-3 drug combos...I know cause I also done all this stuff, only I did DES instead of patch method. Similar therapies but they are not totally identical, noted.
This protocol is used alot more outside the US because of cost and effectiveness issues. It is not super expensive and easy to use, self administered too. Dr. Premoli of Argentina has used this on hundreds of patients for years now and claims no blood clots or deep vein thrombosis (DVT's) found in any of his patients and they only used aspirin for possible clotting. Using patches you by pass the liver, in comparison to using DES (man made estrogen capsules), this might be a plus.
Dr. Premoli protocol: 7.5 mg= 100 ug daily, change patches every 3-4 days or 2 times per week, use only aspirin along with it. (Dr. P. has patient wear these small patches on their scrotums, as funny as that may sound to us, you could place them elsewhere and people do)
USA-friend Nukedad his patch method: Vivelle dot or Climara, Vivelle was smaller and sticks better, doc determines dose level within the patches for the patient, his doc added avodart .5 mg and Dostinex .5 (2x per week along with it) which added to expenses on his useage.
Now why isn't this being used a heck of lot more in the USA right now: 1) men basically freak out when hearing estrogen is for them to use and imagine themselves as perhaps femme 2) docs and institutions make no money on this deal 3) docs assumes all risk in the rare event a blood clot happens and was either fatal or cause long term disability the doc cannot prevail in a court of law and could be out of business. 4) the drug companies selling the expensive norm drugs which are not all peaches and cream if you have tried them are not going to help a profittable establishment loose business, either i.e. they are pushing there expensive stuff and making a killing doing so and your doc also makes a killing on it (believe what you wish)
Docs can screen patients as to blood clotting tests to see if you are a fine candidate or in the high risk spectrum, which is needed to be tested first. It is another choice for us patients, especially if you have limited funds (cash only patient), this might be a program for you that shows results and side effects are alot better than ADT drugs and so are the results, it can work even on hrpca, how long is unknown. No why didn't my uro-doc, rad-doc, maybe even onco-doc ever mention such, or mention other drugs are out there and not mention types or names??? There are alot of other drugs besides the two or three we hear of constantly.
*PCa its a wild world as I have mentioned, there are other protocols also that are not well known too. I only throw this out there so you see more of what is going on out there in PCa world. Estrogen history on PCa is 40-50 yrs. old-btw.
Post Edited (zufus) : 1/26/2009 5:52:01 AM (GMT-7)