I had 37 radiation treatments in the fall of 2007, for myself the hospital was only 5 miles away so it wasn't a problem. Each day I went for treatments the total time I was there was about
30 minutes, unless they were running behind and that only happened a few times.
There were other people having treatments there that lived to far away to commute every day so they stayed at local hotels.
My treatments were monday thru friday, never on the weekends.
The treatments for myself really had no side effects, I was never tired and continued to do everything I done before treatments. The only side effect I had was a slight discomfort in the rectum, but they gave me suppositories and it took care of it.
Wish the best of luck to you