Phase III trials for Alpharadin (Radium-223) injections (4)~interesting results~Norway

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Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 2/7/2009 7:23 AM (GMT -6)   
This is from a company in Norway and is entering phase III trials with these results, it is not that large of a sampling group and will have to pass phase  IV before it may make it to market. Men given this injection of radium-223  (a type of radiation injection-apparently) did pretty well with its useage, in PCa anything of results is considered worth looking at and comparing.
Article says men (treated) vs. placebo men had double the survival time, or course more studies and larger sampling is needed on this, along with any possible side effects or negatives to be noted.
 This method is used on hrpca  (refractive patients)-those who no longer respond to the normal LHRH and casodex types of drugs, but could have response to other drugs that do work against hrpca's just so the record is clear, this trial was on hrpca only. So if people were maybe taking this injection while not considered hrpca the results could even be better (logically thinking, but in PCa that usually does not hold alot of water, but might).
There are alot of trials out there, with trials phase 1 and 2 sometimes decent proprosed protocols sometimes get the axe, and perhaps without all the correct reasons, but that could be a whole discussion, thing. We look for good results from whatever trials are going on.


Post Edited (zufus) : 2/7/2009 5:36:41 AM (GMT-7)

Elite Member

Date Joined Oct 2008
Total Posts : 25381
   Posted 2/7/2009 8:56 AM (GMT -6)   
Today's trials can become tommorows cures, there is always that hope.
Age 56, 56 at DX, PSA 7/7 5.8, 7/8 12.3
3rd Biopsy 9/8 Positive 7 of 7 cores pos, 40-90%, Gleason 7
Open RP surgery 11/14/8, Non-nerve sparing, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
Post-surgery Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsular, clear margins, clear lymph nodes 
First PSA Post Surgery   2/9/9

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