James C the moderator has a lot of good advice on this. I have done the bimix/trimix injections for 5 months now and here are my "helpful hints" or suggestions: I find that grasping the head of my penis and pulling it straight out is the easiest way to get the skin out of the way and makes injecting into the cavernosa easier. A couple of times I didn't pull it out far enough and I ended up injecting into the skin (I guess) because I got no erection and just a big red sore area near the injection site.
Make sure and alternate injection site from one side to other side of penis to minimize scarring. Think of looking at the cross-section of the penis as the face of a sundial with the top being 1200 and the bottom being 600. You want to avoid injecting at 1200 and 600. Although most uro sites recommend the 900 and 300 positions as the best for injecting I personally found I have better luck at the 1000 and 200 positions with better erections. Make sure and move your injection site up and down the penis along these positions to try and not keep injecting at the same place to minimize scarring.
When you have drawn up your syringe of medicine, make sure and roll the syringe back and forth between your hands to warm up the medicine before injecting (I didn't do that the first time, talk about a cold shock)
When you first inject I find it less painful to make an intial jab to pierce the skin rather than slowing pushing into the skin. Then make sure the needle is placed all the way in on the surface especially if using short needles. When he is through the skin and he starts pushing on the plunger if there is a lot of resistance it means that the needle is in the wrong place and he needs to remove the needle and try again. This can be very frustrating at times but it is worth doing right to get good needle placement. You know the needle is in the right place if you press on the plunger and you feel very little resistance. Again there should be very little resistance as you inject into the cavernosa. Push the medicine in slowly over 10 seconds, there should be very little pain doing this.
I don't roll the penis around like James C does after injecting but that sounds like a good idea. I do hold pressure with my thumb or finger over the injection site and opposite side of the penis for a count of 60, 5 times in a row (ie 5 min) before releasing pressure.
I've never used the medicine they gave your SO, I started out with trimix and then bimix. Trimix gives stronger erections than bimix but is more painful than bimix. Mostly I'm used to a lower level of trimix now so I mostly do trimix.
As someone else said on this thread the worst thing about these injections is the lack of spontaneity of sex now. You have to sort of plan everything. Still my wife and I feel this is better than no sex at all and so far the prostate ca has not returned. I am hoping someday to get by with just the little blue pill. Until then my wife and I do have an intimate relationship again...
my age=52 when all this happened,
PSA went from 1.9 to 2.85 in one year, urologist ordered biopsy,
First biopsy on 03/08, "suspicious for cancer but not diagnostic"
Second biopsy on 08/08, 2/12 cores positive for Prostate Cancer on R side, 1 core=5% Ca, other core = 25% Ca, Gleason Score= 3+3=6 both cores,
Clinical Stage T1C
Bilateral nerve sparing Robotic Surgery on 09/11/08, pathological stage T2A at surgery,
No signs of spread, organ contained,
First post-op PSA=.01 on 10/15/08,
Second post-op PSA <.01 on 01/15/09,
Incontinence gone in early December '08,
ED remains, using daily Viagra and 2x/wk bimix/trimix injections for penile rehab