It seems that with a reoccurance after treatment, surgery or radiation, the PSA doubling time usually increases radically. Before treatment the PSA doubling time is usually 2-4 years and yet on a reocurrance it may be months.
Does anyone know why this happens. I read one theory that treatment changes the biology of the cancer, and because it doesn't have any prostate tissue the remaining cells become more agressive.
In all my research I haven't run across any good explaination for this and it seems like this is important and we should know what causes PSA doubling time to increase on reoccurrances and if the treatment itself is making the cancer more agressive.