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Question: Reoccurance, PSA doubling time after treatment

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Prostate Cancer
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John T
Veteran Member
Joined : Nov 2008
Posts : 4315
Posted 3/27/2009 9:24 AM (GMT -7)
It seems that with a reoccurance after treatment, surgery or radiation, the PSA doubling time usually increases radically. Before treatment the PSA doubling time is usually 2-4 years and yet on a reocurrance it may be months.

Does anyone know why this happens. I read one theory that treatment changes the biology of the cancer, and because it doesn't have any prostate tissue the remaining cells become more agressive.

In all my research I haven't run across any good explaination for this and it seems like this is important and we should know what causes PSA doubling time to increase on reoccurrances and if the treatment itself is making the cancer more agressive.

JohnT

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LV-TX
Veteran Member
Joined : Jul 2008
Posts : 966
Posted 3/27/2009 9:49 AM (GMT -7)
Thanks John for asking the question...very good question. I don't have the answer but will follow this closely to see what others say.
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Tony Crispino
Veteran Member
Joined : Dec 2006
Posts : 8151
Posted 3/27/2009 10:02 AM (GMT -7)
John,
I have seen this go both ways. For example I have seen guys spike from a PSA from 2 to 5 or more in a single year of screenng, then elect to have surgery, then start a period of remission. But after 6 months or more some test at 0.1, then 0.15 then 0.17 over the next 6 to 12 months. In fact, I don't find this anymore common either way after treatment. You can see this in many signatures here. Recurrance is gradual in many cases. And BTW, it does not matter if the treatment modality was surgery, EBRT, HT, Cryo, or whatever.

Tony
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