My case appears most unusual, so I am looking for others who may have similar characteristics.
I am 64 with family history of prostate cancer. I religiously had yearly PSA testing and DRE by a top Washington urologist. Over the last 14 years, my PSA has slowly bounced up from 1.0 ng to 1.6 ng (about 28 months ago), then down to 1.3 ng (16 months ago), and then to 2.1 ng (3 months ago). After antibiotics, PSA increaed to 2.6 ng (free PSA was at 26% and PSAD = .05). My urologist said he didn't think I had cancer.
I SAID DO A BIOPSY! PSA velocity trumps everything.
A 15 core biopsy (47cc prostate) revealed 7 positive cores (80%, 60%, 60%, 50%, 40%, 5%, 2%); all rated Gleason 6, and three cores with evidence of perineural invasion (5 weeks ago). The tumor appears to occupy over half the left side of prostate, and 2% of one core from right side.
I am currently queued for Da Vinci robotic RP at NCI (guided by e-coil MRI imagining), but the wait is still over two months, and that is frustrating. Does anybody else know of such an extensive tumor with such a low PSA and high free PSA %? Is my tumor fast growing or did it just not produce much PSA for a long time?