Cholesterol drug cuts risk of recurrence in prostate cancer

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

MichGuy
Regular Member


Date Joined Jan 2009
Total Posts : 51
   Posted 4/26/2009 1:15 PM (GMT -6)   
Here's an interesting study that says statins can lower PCa recurrence risk:

chronicle.augusta.com/stories/2009/04/26/met_521727.shtml

Also, several new studies suggest statins help prevent prostate cancer and reduce the risk of erectile dysfunction:

www.forbes.com/feeds/hscout/2009/04/26/hscout626448.html
Age: 59, 59 at DX
PSA: 1/20/00 7.9, 7/22/00 3.3, 10/25/01 4.9, 10/19/04 5.1, 9/26/07 5.98, 8/28/08 7.68, 9/23/08 7.36, 10/23/08 8.64, 12/18/08 6.39
Prostate size: 96cc
Biopsy: 11/7/08 Positive 2 of 15 cores, both in rt apex, composite tumor quantity 5% prostate involved, Gleason 7 (3+4), Gleason pattern 4 accounts for 15% of tumor
Stage: T1c

Post Edited (MichGuy) : 4/26/2009 12:29:08 PM (GMT-6)


DJBearGuy
Veteran Member


Date Joined Dec 2008
Total Posts : 797
   Posted 4/26/2009 4:30 PM (GMT -6)   
MichGuy,

This would make sense, since statins lower cholesterol, and since cholesterol is a building block for testosterone, the testosterone levels would be down. Like hormone therapy. Which correlates with statins having similar side effects, like decreased libido in many patients. But the part about reducing risk of ED, that has me confused.

P. S. I was on statins myself when I was diagnosed with PCa.

DJ
Diagnosis at age 53. PSA 2007 about 2; PSA 2008 4.3
Biopsy September 2008: 6 of 12 cores positive; Gleason 4+3 = 7
CT and Bone scan negative
Da Vinci surgery at City of Hope December 8, 2008
Radical prostatectomy and lymph node dissection
Catheter out on 7th day, replaced on 8th day, out again 14th day following negative cystogram
Pathology: pT2c; lymph nodes negative; margins involved; 41 grams, 8% involved by tumor; same Gleason 4+3=7
PSA 1/22/08 non-detectable! 8-)
4/23/09 still undetectable!


MichGuy
Regular Member


Date Joined Jan 2009
Total Posts : 51
   Posted 4/26/2009 7:00 PM (GMT -6)   
DJ,

You said: "But the part about reducing risk of ED, that has me confused. "

Well, the article says: "Protection of vascular health remains an important concomitant of preserving erectile health. Our data suggest that longer use of statins may result in the lowest risk of erectile dysfunction," study author Dr. Ajay Nehra said in a statement.

It seems to make sense to me that the less clogged up your blood vessels are, the less likely your chances of developing ED.

MichGuy
Age: 59, 59 at DX
PSA: 1/20/00 7.9, 7/22/00 3.3, 10/25/01 4.9, 10/19/04 5.1, 9/26/07 5.98, 8/28/08 7.68, 9/23/08 7.36, 10/23/08 8.64, 12/18/08 6.39
Prostate size: 96cc
Biopsy: 11/7/08 Positive 2 of 15 cores, both in rt apex, composite tumor quantity 5% prostate involved, Gleason 7 (3+4), Gleason pattern 4 accounts for 15% of tumor
Stage: T1c
DaVinci robotic surgery: 3/9/09, Dr. M. Hugh Solomon at St. Joseph Mercy Hospital, Ann Arbor, MI
Nerves: Spared left nerve bundle and partial sparing of right nerve bundle
Cath removed: 3/19/09
Pathology results: Gleason: 3+3=6, Tumor Quality: 3% of prostatic tissue; max. linear extent 4 mm, location: bilateral (apices), no extracapsular extension, no seminal vesicle invasion, no perineural invasion and no angiolymphatic invasion. Margins: Focal involvement (1mm) of left apical margin
Pathologic stage: pT2c N0 Mx

Post Edited (MichGuy) : 4/27/2009 2:23:43 PM (GMT-6)


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 4/26/2009 7:29 PM (GMT -6)   
I was on statins 14 years before getting my diagnosis...
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25382
   Posted 4/26/2009 8:15 PM (GMT -6)   
I have never been on any in my life or currently
Age 56, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
Post-surgery Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsular, clear margins, clear lymph nodes 
First PSA Post Surgery   2/9 .05, 6 month on 5/9
 
 


don826
Veteran Member


Date Joined May 2008
Total Posts : 1010
   Posted 4/27/2009 10:01 AM (GMT -6)   

Interesting articles and hypotohesis. I have taken statins for fourteen years and still was diagnosed with an advanced case a year ago. Perhaps I will see some of the post treatment benefit although I did not have surgery.

Thanks for the informative post.

Don

 


Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones 
 
 
 


MichGuy
Regular Member


Date Joined Jan 2009
Total Posts : 51
   Posted 4/27/2009 10:41 AM (GMT -6)   
It's interesting how many people here have been on statins and got PCa anyway. I guess it's not the prevention panacea I initially expected. I wonder if it really has as much effect on recurrence as the study implied.

MichGuy
Age: 59, 59 at DX
PSA: 1/20/00 7.9, 7/22/00 3.3, 10/25/01 4.9, 10/19/04 5.1, 9/26/07 5.98, 8/28/08 7.68, 9/23/08 7.36, 10/23/08 8.64, 12/18/08 6.39
Prostate size: 96cc
Biopsy: 11/7/08 Positive 2 of 15 cores, both in rt apex, composite tumor quantity 5% prostate involved, Gleason 7 (3+4), Gleason pattern 4 accounts for 15% of tumor
Stage: T1c
DaVinci robotic surgery: 3/9/09, Dr. M. Hugh Solomon at St. Joseph Mercy Hospital, Ann Arbor, MI
Nerves: Spared left nerve bundle and partial sparing of right nerve bundle
Cath removed: 3/19/09
Pathology results: Gleason: 3+3=6, Tumor Quality: 3% of prostatic tissue; max. linear extent 4 mm, location: bilateral (apices), no extracapsular extension, no seminal vesicle invasion, no perineural invasion and no angiolymphatic invasion. Margins: Focal involvement (1mm) of left apical margin
Pathologic stage: pT2c N0 Mx


DJBearGuy
Veteran Member


Date Joined Dec 2008
Total Posts : 797
   Posted 4/27/2009 3:00 PM (GMT -6)   
Mich,

Thanks for the clarification about ED and vascular health. Sometimes I forget that ED and libido are physiologically separate.

DJ
Diagnosis at age 53. PSA 2007 about 2; PSA 2008 4.3
Biopsy September 2008: 6 of 12 cores positive; Gleason 4+3 = 7
CT and Bone scan negative
Da Vinci surgery at City of Hope December 8, 2008
Radical prostatectomy and lymph node dissection
Catheter out on 7th day, replaced on 8th day, out again 14th day following negative cystogram
Pathology: pT2c; lymph nodes negative; margins involved; 41 grams, 8% involved by tumor; same Gleason 4+3=7
PSA 1/22/08 non-detectable! 8-)
4/23/09 still undetectable!

New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, August 19, 2018 8:06 AM (GMT -6)
There are a total of 2,994,316 posts in 328,121 threads.
View Active Threads


Who's Online
This forum has 161270 registered members. Please welcome our newest member, Hopeful1brunner.
245 Guest(s), 6 Registered Member(s) are currently online.  Details
GreenBeans, Cigafred, JayMot, kit49, bubbatc, iPoop