Pomegranite juice

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John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4168
   Posted 4/27/2009 2:23 PM (GMT -7)   

Pomegranate juice may benefit men treated for localized prostate cancer http://psa-rising.com/foodnews/2009/04/pomegranate-juice-may-benefit-men-treated-for-localized-prostate-cancer/#content

 

Pomegranate juice may slow the progression of post-treatment prostate cancer recurrence, according to new long-term research results being presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA), April 2009.

 

Researchers found that men who have undergone treatment for localized prostate cancer could benefit from drinking pomegranate juice by seeing a significant slowing of the rate of PSA rise.

 

The two-stage clinical trial followed a total of 48 participants over six years. Eligible men had a rising PSA after surgery or radiotherapy, a PSA greater than 0.2 ng/ml and less than 5 ng/ml and a Gleason score of 7 or lower.

 

Patients in the “active” arm of the study are prescribed eight ounces of pomegranate juice daily. Currently, in the sixth year of treatment, the men who are drinking the pomegranate juice and who remain on the study have a median total follow-up of 56 months. The pomegranate juice appears to be impacting their PSA doubling time.

 

Researchers compared active patients, who remain on the study, with non-active patients (not drinking juice), who no longer remain on the study. Though these two groups demonstrated similar mean PSA doubling times at baseline, both the PSA doubling time prolongation and the decline in median PSA slope were greater in active patients when compared to non-active patients.

 

At the start of the study, patients showed a median PSA doubling time of

15.4 months (relatively fast and aggressive). After treatment, the median doubling time has stretched to60 months (5 years), with a median PSA slope decrease of 60 percent, 0.06 to 0.024. The men continue to experience a significant slowing of their PSA doubling time following treatment.

 

“This study suggests that pomegranate juice may effectively slow the progression of prostate cancer after unsuccessful treatment,” said Christopher Amling, MD, an AUA spokesman. “This finding and other ongoing research might one day reveal that pomegranate juice is an effective prostate cancer preventative agent as well.”

 

Parts of this ongoing study suggest that some patients may be more sensitive to the effects of pomegranate juice on PSA doubling time.

Phase three of this study is currently underway to further evaluate the benefits of pomegranate juice in a placebo-controlled manner.

 

PREVIOUSLY on this topic:

http://www.psa-rising.com/eatingwell/pomegranate-juice06.htm

 JohnT


64 years old.

I had an initial PSA test in 1999 of 4.4. PSA increased every 6 months reaching 40 in 5-08. PSA free ranged from 16% to 10%. Over this time period I had a total of 13 biopsies and an endorectal MRIS all negative and have seen doctors at Long Beach, UCLA, UCSF and UCI. DX has always been BPH and continue to get biopsies every year.

In 10-08 I had a 25 core biopsy that showed 2 cores positive, gleason 6 at less than 5%. Surgery was recommended and I was in the process of interviewing surgeons when my wife's oncologist recommended I get a 2nd opinion from a prostate oncologist.

I saw Dr Sholtz, in Marina Del Rey, and he said that the path reports indicated no tumor, but indolant cancer clusters that didn't need any treatment. He was concerned that my PSA history indicated that I had a large amount of PC somewhere that had yet to be uncovered and put me through several more tests.

A color doppler targeted biopsy in 11-08 found a large tumor in the transition zone, gleason 6 and 7. Because of my high PSA Dr. suspected lymph node involvement, 30% chance, and sent me to Holland for a Combidex MRI, even though bone and CT scans were clear.

Combidex MRI showed clear lymph nodes and a 2,5 cm tumor in the anterior. I was his 1st patient to come up clear on the Combidex which has a 96% accuracy,

I've been on a no meat and dairy diet since 12-08 and PSA reduce to 30 while I awaited the Combidex MRI.

The location of the tumor in the anterior apex next to the urethea makes a good surgical margin very unlikely. Currently on Casodex and Proscar for 8 weeks to shrink my 60 mm prostate. Treatment will be seeds followed by 5 weeks of IMRT while continuing on Casodex and Proscar. So far no side affects from the Casodex.

As of April 10 and 7 weeks on Casodex and Proscar PSA has gone from 30 to 0.62 and protate from 60mm to 32mm. Very minor side affects. Doc says all this indicates tumor is not aggessive

Awaiting schedule for seed impants

 


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 4/27/2009 10:31 PM (GMT -7)   
John,
There is a strong case being made for controlling PSA doubling times with pomagranite juice or supplementation. I regularly bump up the Scientific Retreat for last year here which contains the lead scientists findings in presentation format. The questions are two fold.
1> Is pomagranite supplementation merely hindering PSA testing? and if not...
2> Is the slowing of the doubling rate actually helping mortality rates?

From what I am learning, I have added Pom to my shopping list. It's not a huge improvement, but it is a significant one so far.

Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (January 13, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25353
   Posted 4/28/2009 5:38 AM (GMT -7)   
Like other dietary changes after a medical crisis of any sort, any change in what we eat or drink to promote good health is always a good thing. I think officially, the jury is still out on any real verified advantages of drinking pomagranite juice or not. Certainly not going to hurt anyone.

Me, I drink water nearly 100 % of the time, and have for the past 20 years. I rarely drink fruit juice or caffine free diet soda, but mostly water.

David in SC
Age 56, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
Post-surgery Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsular, clear margins, clear lymph nodes 
First PSA Post Surgery   2/9 .05, 6 month on 5/9
 
 


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4168
   Posted 4/28/2009 9:03 AM (GMT -7)   
Pomegranite juice is expensive. A less espensive way to get the same thing is to take the capsules.

64 years old.

I had an initial PSA test in 1999 of 4.4. PSA increased every 6 months reaching 40 in 5-08. PSA free ranged from 16% to 10%. Over this time period I had a total of 13 biopsies and an endorectal MRIS all negative and have seen doctors at Long Beach, UCLA, UCSF and UCI. DX has always been BPH and continue to get biopsies every year.

In 10-08 I had a 25 core biopsy that showed 2 cores positive, gleason 6 at less than 5%. Surgery was recommended and I was in the process of interviewing surgeons when my wife's oncologist recommended I get a 2nd opinion from a prostate oncologist.

I saw Dr Sholtz, in Marina Del Rey, and he said that the path reports indicated no tumor, but indolant cancer clusters that didn't need any treatment. He was concerned that my PSA history indicated that I had a large amount of PC somewhere that had yet to be uncovered and put me through several more tests.

A color doppler targeted biopsy in 11-08 found a large tumor in the transition zone, gleason 6 and 7. Because of my high PSA Dr. suspected lymph node involvement, 30% chance, and sent me to Holland for a Combidex MRI, even though bone and CT scans were clear.

Combidex MRI showed clear lymph nodes and a 2,5 cm tumor in the anterior. I was his 1st patient to come up clear on the Combidex which has a 96% accuracy,

I've been on a no meat and dairy diet since 12-08 and PSA reduce to 30 while I awaited the Combidex MRI.

The location of the tumor in the anterior apex next to the urethea makes a good surgical margin very unlikely. Currently on Casodex and Proscar for 8 weeks to shrink my 60 mm prostate. Treatment will be seeds followed by 5 weeks of IMRT while continuing on Casodex and Proscar. So far no side affects from the Casodex.

As of April 10 and 7 weeks on Casodex and Proscar PSA has gone from 30 to 0.62 and protate from 60mm to 32mm. Very minor side affects. Doc says all this indicates tumor is not aggessive

Awaiting schedule for seed impants

 


geezer99
Veteran Member


Date Joined Apr 2009
Total Posts : 990
   Posted 4/28/2009 12:33 PM (GMT -7)   
Thanks for the information and also thanks to Tony for his sensible remarks.

The authors have been doing this study for some time. I haven't found their newest report but here is a link to their 2006 article on the same study. As I understand it, the latest report added a control group for comparison. Another of their findings was that at least pomegranate juice seemed harmless even when not particularly beneficial
http://clincancerres.aacrjournals.org/cgi/content/full/12/13/4018?ijkey=YHug.edCmkCu.&keytype=ref&siteid=aacrjnls

I keep looking for the new paper and let you know if I find it.
Age at diagnosis 67, PSA 5.5
Biopsy 12/08 12 cores, 8 positive
Gleason 3 + 4 = 7
CAT scan 1/09 negative, Bone scan 1/09 negative

Robotic surgery 03/03/09 Catheter Removed 03/08/09
Post surgical pathology report. Lymph nodes negative, Seminal vesicles negative
Surgical margins positive, Capsular penetration extensive Gleason 4 + 3 = 7

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