If the Trimix is failing, you can always go to Caverject or Edex which is straight Alprostadil. I started with Caverject Impulse (not available now until summer 2010) then the pharmacy switched me to Edex. Both worked great but I also had the aching pain. 40 ml of either one will give most men a 4 hour erection that is so hard that you can't believe it.
I went through the 4 hour experiences and aching pain, so my urologist switched me to Trimix. It has been working fine, anywhere from a one to two hour erection. And no pain. I don't take an ED drug before. Just the injection and it works in 5 minutes.
PSA 2007 4.1
PSA 2008 10.0
Diagnosed April 2008
Biopsy: 6 of 12 cores positive
Gleason 4 + 5 = 9
CT and Bone Scan negative
Open surgery at Shawnee Mission Medical Center May 21, 2008
Right side nerves spared
Radical prostatectomy and lymph node dissection
Cather removed on June 3rd, totally dry on July 9th
lymph nodes negative
PSA Sept 28, 2008 0.00
PSA Jan 22, 2009 0.00