radiation, psa rising, what t do next?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined May 2009
Total Posts : 85
   Posted 5/3/2009 5:33 PM (GMT -6)   
HI: I have a question about treatment. My husband had radiation Oct 07. His psa was 107, his gleason 8 T2 or T3(not sure if out of prostate capsule). He also is on luron shots every 4 months. His psa went down to .3 by December of 09. Than March 31 it went up to .7 and now May 1st it is 1.54. Does this mean the radiation did not work? Is the lurpon not working? Would it help to add casadex?   Can anyone out there who has had this happen tell me what the did for treatment.  He is under an oncologists care, but would like anyone opinion that has had this happen.  Husband is 54 years old.
  <!-- showSig: kk55 -->

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4237
   Posted 5/3/2009 5:39 PM (GMT -6)   
He should have been on Casodex and proscar along with Lupron from the beginning. Is your oncologist a prostate specialist or an oncologist that treats many types of cancer?

64 years old.

I had an initial PSA test in 1999 of 4.4. PSA increased every 6 months reaching 40 in 5-08. PSA free ranged from 16% to 10%. Over this time period I had a total of 13 biopsies and an endorectal MRIS all negative and have seen doctors at Long Beach, UCLA, UCSF and UCI. DX has always been BPH and continue to get biopsies every year.

In 10-08 I had a 25 core biopsy that showed 2 cores positive, gleason 6 at less than 5%. Surgery was recommended and I was in the process of interviewing surgeons when my wife's oncologist recommended I get a 2nd opinion from a prostate oncologist.

I saw Dr Sholtz, in Marina Del Rey, and he said that the path reports indicated no tumor, but indolant cancer clusters that didn't need any treatment. He was concerned that my PSA history indicated that I had a large amount of PC somewhere that had yet to be uncovered and put me through several more tests.

A color doppler targeted biopsy in 11-08 found a large tumor in the transition zone, gleason 6 and 7. Because of my high PSA Dr. suspected lymph node involvement, 30% chance, and sent me to Holland for a Combidex MRI, even though bone and CT scans were clear.

Combidex MRI showed clear lymph nodes and a 2,5 cm tumor in the anterior. I was his 1st patient to come up clear on the Combidex which has a 96% accuracy,

I've been on a no meat and dairy diet since 12-08 and PSA reduce to 30 while I awaited the Combidex MRI.

The location of the tumor in the anterior apex next to the urethea makes a good surgical margin very unlikely. Currently on Casodex and Proscar for 8 weeks to shrink my 60 mm prostate. Treatment will be seeds followed by 5 weeks of IMRT while continuing on Casodex and Proscar. So far no side affects from the Casodex.

As of April 10 and 7 weeks on Casodex and Proscar PSA has gone from 30 to 0.62 and protate from 60mm to 32mm. Very minor side affects. Doc says all this indicates tumor is not aggessive

Awaiting schedule for seed impants


Regular Member

Date Joined May 2009
Total Posts : 85
   Posted 5/3/2009 10:15 PM (GMT -6)   
stats: march 2006 psa 107,gleason 8, stage T2 or T3 weren't sure if had gone out of prostate capsule. Went on lupron/casadex for 3 moths, than stayed on lupon (1 shot every 4 months). Radiation October of 2007. December of 2008 psa .03 now May 1st psa is 1.54. Still on lupron shots. Age 54.

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 5/4/2009 12:36 PM (GMT -6)   
I have to agree that the oncologist should restart the Casodex. But if he should restart it and not get the desired results, then there may be a need to consider looking into chemotherapy. While I am not that far along, because we expected to be I have done a great deal of research on this path. Such treatments that exist to look at are: Ketocanzole, Abratirone (Pre-chemo trial just started), Provenge (Should be released by EOY 2009) and other clinical trials. I would not be surprised if reintroducing Casodex brought your husband back to remission.

Welcome to HealingWell. There are many members who have had a similar experience and can share their view. I have one recommendation ~ Stay positive. There is always hope.

Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (January 13, 2009): <0.1
My Journal is at Tony's Blog  

Regular Member

Date Joined May 2009
Total Posts : 85
   Posted 5/4/2009 3:11 PM (GMT -6)   
Thank you for your positive comments. We knew when radiation was started that because of his high psa the radiation may not work, but we ar trying to look at things days by day and hope is what we cling to.
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, July 23, 2018 10:47 AM (GMT -6)
There are a total of 2,984,579 posts in 327,239 threads.
View Active Threads

Who's Online
This forum has 162021 registered members. Please welcome our newest member, jonll.
404 Guest(s), 12 Registered Member(s) are currently online.  Details
81GyGuy, GoBucks, mysweetpanda, abhi, sandyfeet, tickbite666, Wilderness, Michael_T, ks1905, Clam Digger, Tall Allen, jonll