I had two months of testosterone after my first clear PSA in January 2009 (surgery November 2008). I was a special case since I had a Lupron injection (long story) and needed the T to overcome the effects of the Lupron.
The testosterone really made a big difference in my INTEREST in sex, and that interest drove my renewed confidence. I was disappointed and anxious about something I had always taken for granted. This might have created some psychological barriers. After the testosterone I found myself smiling at the young mothers in the supermarket. I'm sure they were thinking "Old Pervert!" but they all smiled back. Over-confidence is better than no confidence!
Testosterone replacement is getting to be a big deal. It's starting to be advertised on television. You won't hear urologists talk about it being needed because of its connection to PC, but a lot of other doctors are beginning to relalize the need for it. Not only are we living longer, but we expect to be sexually active longer. Insufficient testosterone drives many health and mental issues. Google low testosterone to see what I am talking about.
I highly recommend Dr Eugene Shippen's book The Testosterone Syndrome available on Amazon for $16. Chapter 10 about the role of testosterone in women is a real eye opener. I don't take testosterone replacement any more, but my wife does!
Shippen also contributes to the books by Suzanne Somers. Ageless is a good read.
T replacement has almost zero side effects. I didn't see any. You may need to go beyond your urologist. That's what I did. It's a tightly controlled drug because of its abuse in the sports world, but readily available with a prescription from your doctor. It's certainly worth a shot for your friend.
Do you mind disclosing your prostate size? It's none of my business, of course, ...(but I want to run your numbers)