Had my fist experiment with Trimix

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Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 5/10/2009 9:17 PM (GMT -6)   
Wow! I've been reluctant to use Trimix but the VED pump didn't do it for me and ED meds are useless since my nerves were not spared. I finally broke down and injected my self with .1 cc as my doctor suggested. It gave me half an erection so after 20 minutes I injected another .1cc on the other side of the penis. Within 15 minutes I had a great erection and had my first intercourse since my surgery. My erection lasted almost 2 hours. Hello Trimix.
Age: 67
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
Dx 12/30/08
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09
Surgeon: Dr. Randy Fagin, Austin TX.
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Bilateral 10-20% involved
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx
Negative margins
seminal vesicles clean
Lymph nodes: not dissected
1st PSA test 4/7/09 result <0.1


rsilver
New Member


Date Joined Mar 2009
Total Posts : 19
   Posted 5/10/2009 10:33 PM (GMT -6)   
hey Ed and anyone else who is considering this, I have used a variation of this for almost a decade (before PCa) and its awesome. I would encourage those who have had no sucess with oral medications to try and use this. Its no more than a bee sting, and the results are more than worth it..........bob......no side effects but you gotta be careful of priapism

Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4829
   Posted 5/11/2009 4:23 AM (GMT -6)   
I'm going to have my first test run at the docs office this Thursday...
 
Does insurance cover it and or is it expensive?
Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
 
06/25/08 - Da Vinci robotic laparoscopy
Catheter in for five weeks.
Dry after 3 months.
 
10/03/08 - 1st Quarter PSA -> less then .01
01/16/09 - 2nd Quarter PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.
 


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 5/11/2009 6:25 AM (GMT -6)   
Congrats to you Ed. This has to put a new dimension to your recovery, so glad it worked that well for you on the first try.

David in sC
Age 56, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
Post-surgery Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsular, clear margins, clear lymph nodes 
First PSA Post Surgery   2/9 .05, 6 month on 5/9
 
 


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 5/11/2009 8:09 AM (GMT -6)   
Steve, Trimix costs around $97 or so dollars, ordered from a compounding pharmacy and overnight shipped in a cold pack to you. It must be kept refrigerated until use. A vial will contain around 50 .1cc doses (5ML), so numbers will vary as to how much you have to use to achieve the desired effect. Bimix costs around $50 and doesn't require the cold shipping as Trimix does. There's lots of info in the back pages of the Forum, so if you want I can post some links to them when you get ready to try it...?
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
21 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months


KeyWestPirate
Regular Member


Date Joined May 2009
Total Posts : 60
   Posted 5/11/2009 9:16 AM (GMT -6)   
I'd like to try TRIMIX too, my urologist never mentioned it. I have no problem with the needle.

I'm getting along OK with the Viagra or Cialis and VED, but I'd like to begin to move away from the VED. There are problems with spontaneity and dependence. I'm only 6 months post-op and may be trying too hard, but I feel that the pump is creating some confidence issues for me and a dependency on my wife's part. I really want to get back to where I was, pre-op. Just being diagnosed with PC is a huge confidence destroyer. We can all remember how we felt when we got the news. Then, EVEYONE tells us about erectile issues and diapers. That's the way it USED to be.

I think psychology (in the form of performance anxiety) is playing a bigger part here than many of us realize. Remember, it wasn't that long ago that ALL erectile dysfunction was considered to be "in your head":

"Over the past two decades, the concept of erectile dysfunction has evolved from that of a disorder referred to as impotence and considered predominantly psychogenic to that of erectile dysfunction (ED), a well-understood physiologic result of multiple risk factors, both organic and psychological, which result in inadequate erectile function for coitus. Masters and Johnson suggested in 1970 that the majority of ED cases were psychogenic in nature, with less than 10% involving organic abnormalities.1 In 1972, Finkle and Thompson wrote that “pragmatic counseling” rather than psychotherapy renewed sexual function.2 These clinicians suggested that “congestive prostatitis” was associated with a psychological burden, a “problem in the head.” The first extensive epidemiologic study of male sexual behavior in the United States was reported in 1948 by Kinsey and colleagues.3 They concluded that the prevalence of ED was less than 1% in men younger than 30 years, less than 3% in those 30–45, 6.7% in those 45–55, 13.5% in those 55–65, 25% in those 65 and up, and up to 80% in those 80 years of age or more. Unfortunately, however, their sample of patients older than 55 was small, and the results for older ages not significant. It was not until the Massachusetts Male Aging Study in 1987 to 1989 and the National Health and Social Life Survey in 1992 that prevalence of ED in men in the United States was accurately measured as more than 50% in those above 40 and 31% in men overall.4,5"

We EXPECT to have erectile issues, so our brains are conveniently obliging us by making it happen.



>>>>>>>>> James C.;
could you share the compounding pharmacy you are using? We have a local compounding pharmacy that my wife uses for her bio-identical HRT, but they are expensive.
I notice that you pump 3X weekly, so do I -five times last week :)
Do you consider Trimix part of your recovery protocol as well as an erectile aid?

>>>>>>>Has anyone experimented with some anxiety medication, like Xanax?
The next meet with my urologist is in July, PSA and testosterone level. I'm going to hit him up for the Trimix and Xanax. I'll probably have to get nasty . . .
I quit taking the testosterone after 2 months because your body's natural production will shut down if there is sufficient testosterone from an external source.
It's a well known fact among body builders who inject T. They live with shrunken testicles.

This ED business is much more complex than any of us realize . . . especially our doctors!


_____________________________________________
Robotic RP 11/23/2008 Nerve bundles spared. Gleason 6, PSA 6.5, Totally contained, two subsequent tests showed undetectable PSA. Testosterone January 2009 for 2 months to offset effects of Lupron shot June 2008. T level Jan2009: 238; April 2009 677 "Usable" erectile function at 3 weeks, steadily getting better Still need Viagra or Cialis for workable erection; + VED to meet wife's expectations.

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/11/2009 9:45 AM (GMT -6)   
Great story,
And great results. I am watching this therapy closely and may become a customer soon. Thanks for sharing, Ed.

Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (January 13, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 5/11/2009 10:37 AM (GMT -6)   
Key...etc.....Most of us here use Franck's Compounding Pharmacy. They required a signed prescription either mailed or faxed to them to fill the order, and is paid with a credit card. Here's their link:
www.francks.com/?action=h_urology

I use the pills, pump and injections all as recovery therepy until such time as I finally give up. shakehead There has been some studies that say that use of injections will help with an earlier recovery from post-RRP ED results. Again, individiual results may vary, etc.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
21 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months

Post Edited (James C.) : 5/11/2009 11:51:43 AM (GMT-6)


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4829
   Posted 5/11/2009 11:13 AM (GMT -6)   

James - thanks for the info and for bumping the older threads. Your link to

www.francks.com/?action=h_urology

Has one too many / in the front of it so its broken.


Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
 
06/25/08 - Da Vinci robotic laparoscopy
Catheter in for five weeks.
Dry after 3 months.
 
10/03/08 - 1st Quarter PSA -> less then .01
01/16/09 - 2nd Quarter PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.
 


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 5/11/2009 8:52 PM (GMT -6)   
I paid $85 for 5ml of trimix and a package of 1/2 inch gauge 30 needles at Peoples Pharmacy in Austin Texas. They gave me all the information I needed to administer the injection.
Age: 67
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
Dx 12/30/08
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09
Surgeon: Dr. Randy Fagin, Austin TX.
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Bilateral 10-20% involved
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx
Negative margins
seminal vesicles clean
Lymph nodes: not dissected
1st PSA test 4/7/09 result <0.1

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