Veridex circulating tumor cell test?

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don826
Veteran Member


Date Joined May 2008
Total Posts : 1010
   Posted 5/13/2009 12:14 PM (GMT -6)   
To All,
 
I would like to know if anyone has had this test run. If so, what is your opinion of the test and how useful did your attending physician find the information produced by the test? Did you have the test done as a diagnostic tool or as a monitoring tool post treatment?
 
My reason for asking is that I am one year into my ADT and eight months post radiation. I am not sure PSA is really a reflection of my situation. My case was considered advanced at diagnosis.
 
Any comments would be appreciated. Last PSA was .3 taken on May 11, 2009.
 
Don
Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones 
 
 
 


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4826
   Posted 5/13/2009 12:41 PM (GMT -6)   

For those like me that don't what it is...Here's a liitle excert:

CLEVELAND CLINIC RECOGNIZES CIRCULATING TUMOR CELL TECHNOLOGY AS TOP MEDICAL INNOVATION FOR 2009
http://www.nnpkit.com/veridex/cellsearch/

The CellSearch® System is the first diagnostic test to automate the capture and detection of tumor cells that have detached from solid tumors and entered the patient’s blood. With the CellSearch® System, it is possible to reproducibly find a single circulating tumor cell among approximately 40 billion blood cells in a 7.5 mL blood sample.

The ability to identify a single cancer cell through this innovative technology provides physicians with an important measure of a patient’s disease prognosis to help them make more informed patient care decisions. Dr. Mark Graham, a practicing oncologist from Waverly Hematology Oncology in Cary, North Carolina, has used CellSearch® for the past two years to regularly monitor the prognosis of his population of metastatic breast cancer patients.

 


Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
 
06/25/08 - Da Vinci robotic laparoscopy
Catheter in for five weeks.
Dry after 3 months.
 
10/03/08 - 1st Quarter PSA -> less then .01
01/16/09 - 2nd Quarter PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.
 


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/13/2009 2:30 PM (GMT -6)   
I had this test.
Mine came back zero. CTC is good for us advanced guys. I will have another in October...

Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (January 13, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


don826
Veteran Member


Date Joined May 2008
Total Posts : 1010
   Posted 5/13/2009 3:04 PM (GMT -6)   

Hello Steve and Tony,

Steve thanks for posting the test.

Tony, I assume that you found the information afforded by the test to be of a benefit since you are planning to take it again. From what I can gather it is best used as a gauge of disease progression and can give an early warning. Don't know if it is earlier than PSA.

Thanks again to both of you for your replies.

Don 


Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones 
 
 
 


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/13/2009 5:19 PM (GMT -6)   
PSA can rise in the case of a local recurrance. Finding tumor cells in blood is indicitive of metastatic disease potential. So the CTC is more useful in identifying metastatic disease earlier. It is unclear to me that it would change a treatment plan. When my doctor did the test, if CTC found any circulating cells, it was unclear if we should start chemotherapy based on the results. But likely that would be the case. My oncologist participates in the study of CTC. It was part of that study that my blood was drawn.

Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


don826
Veteran Member


Date Joined May 2008
Total Posts : 1010
   Posted 5/13/2009 6:45 PM (GMT -6)   
Hi Tony,

Yes, the reason I was looking at this was to determine if I should be looking at chemo or perhaps a trial if my treatment so far turns out to be ineffective. My uro told me at the outset that my odds were slim. The radiation oncologist was a bit more optimistic at 70% chance of cure. The frustrating thing is that there is so darned little than can be measured to provide one with a comfort level that the treatment is yielding results. (or not) I will begin my second year of ADT (monotherapy) this coming Friday. The hormone suppresses the PSA so how do you know if the radiation has had any effect? I have had almost none of the radiation side effects with the exception of a brief period during treatment.

Thanks again for your input. It is much appreciated.

Take care,
Don
Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones 
 
 
 

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