I have noticed, after following a number of signatures from other members, that the lowest ultra-sensitive level is achieved on the first test after surgery. This assumes that sufficient time has elapsed to to allow for the prostate-generated PSA to decay away. Some men eventually experience a biochemical recurrence, reaching 0.2ng/ml. However, this seems to be true for many men who probably will never have a recurrence. Levels seem to go up a bit from the post-surgery test, plateau, or move back down. Some men are lucky and see a steady sequence of levels over time. However, I don't think I have EVER seen a decay down from the first test, e.g. 0.04, 0.02. 0.01, etc.
This is by no means a scientific observation. I was wondering if anyone else has noticed this and whether there is a medical explanation. I know of the "bounce" from radiation treatment, but I have not heard of a "bounce" described for surgery. I thought I had read a one time that the prostate not only produces PSA but absorbs some of it as well. This might explain explain why the loss of a prostate lets other minute sources of PSA (Cowper's gland, etc.) become more apparent over time. Thoughts?
Age:45 (44 when diagnosed)
Father diagnosed and cured at age 52.
08/21/07: Diagnosed with T1c cancer
1 of 12 biopsy cores positive; 10% tissue
Gleason score: 3+3=6
PSA level prior to biopsy: 4.3 (velocity < 0.4ng/ml)
10/19/07: da Vinci prostatectomy by Dr. Vipul Patel
Difficult surgery due to prostate inflammation.
Both nerve bundles spared.
Spongy erections began within 24hrs of surgery!
10/24/07: Catheter out; down to 1 Serenity pad/day next day.
Final pathology: neg margins, no capsular penetration,
Gleason 3+3=6, 5% tumor involvement, multi-focal.
11/04/07 First usable erection with Cialis
11/22/07 Thanksgiving - Bye-bye, pads
01/17/08 First post-surgery PSA result: < 0.008 ng/ml
03/17/08 Erection quality mostly back to pre-surgery levels with Cialis;
have not tried without meds yet.
04/23/08 Second post-surgery PSA result: < 0.008 ng/ml
07/30/08 Third PSA: 0.01 ng/ml
11/04/08 One year PSA: 0.01
Still taking 10mg Cialis every other day - enjoying the results
too much to stop yet.
02/07/09 Taking 5mg Cialis every other day - having too much fun to try
to stop for now.
03/23/09 PSA: 0.02