I have noticed, after following a number of signatures from other members, that the lowest ultra-sensitive level is achieved on the first test after surgery. This assumes that sufficient time has elapsed to to allow for the prostate-generated PSA to decay away. Some men eventually experience a biochemical recurrence, reaching 0.2ng/ml. However, this seems to be true for many men who probably will never have a recurrence. Levels seem to go up a bit from the post-surgery test, plateau, or move back down. Some men are lucky and see a steady sequence of levels over time. However, I don't think I have EVER seen a decay down from the first test, e.g. 0.04, 0.02. 0.01, etc.
This is by no means a scientific observation. I was wondering if anyone else has noticed this and whether there is a medical explanation. I know of the "bounce" from radiation treatment, but I have not heard of a "bounce" described for surgery. I thought I had read a one time that the prostate not only produces PSA but absorbs some of it as well. This might explain explain why the loss of a prostate lets other minute sources of PSA (Cowper's gland, etc.) become more apparent over time. Thoughts?