Tumor Size a Predictor of Reocurrance

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Radical
Veteran Member


Date Joined Mar 2009
Total Posts : 739
   Posted 5/14/2009 2:38 AM (GMT -6)   
Forgive me guys, I have been investigating the net today and have come up with another interesting article, which I thought I would share in relation to Tumor volume and predicting a
reocurrance. (link attached)
 
I must admit, I am finding it hard to calculate my Tumor volume and Prostate Size. I could use some help in there are any budding mathematicians out there...........Cheers Nothard
 
Prostate Size according to pathology report is 3.5x3.0x2.5 = ? cc
Tumor Volume in total =  0.98cm3 is that just simply 0.98 cc's (if so isnt that pretty small ?)
 
 
http://www.drcatalona.com/quest/quest_winter03_2.asp
Age 51yrs
DX 11/11/08
6 out of 8 cores positive 3 X 60% / 3 X 10%
PSA 4
Gleason 3+4=7
Stage T1c
Robotic Surgery 24/12/08
Upgrade Gleason 4+3=7 (60% Grade 4)
Stage T2c
Three small foci total volume 10%
Neg Margins and Nodes
Nil - Extraprostatic Extentions
Dry less than 1 week.
ED- taking Meds/ No results yet/still "NotHard"
PSA 28/1/09 0.03
PSA 24/2/09 0.03
"Everyday in Everyway I get better"


BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 5/14/2009 3:29 AM (GMT -6)   
It's a little difficult because the gland itself is an irregular shape. If you knew the prostate's weight in grams then the volume is the same in cubic centimetres (cc or cm3)...human tissue has much the same density as water. As to a calculated volume, the volume of a sphere is 4/3 x 22/7 x R3......at 3.5cm diameter then the volume would be 22.5cc but the gland being somewhat of a squat sphere it would be a little less that that. all in all it would appear that the tumour was about 5-10%. If the tumour was spherical it would have a diameter of about 1.2 cm. But nothing with a prostate is a regular shape, especially the tumours within (or without).
Bill
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07
4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable
PSA April 08 <0.001 undetectable (disregarded due to lab "misreporting")
PSA August 08 <0.001 undetectable (disregarded due to lab "misreporting")
Post-op pathology rechecked by new lab:
Gleason downgraded to 4+3=7
Focal extension comprised of grade 3 cells
PSA September 08 <0.01 (new lab)
PSA February 09 <0.01


Radical
Veteran Member


Date Joined Mar 2009
Total Posts : 739
   Posted 5/14/2009 3:49 PM (GMT -6)   
Thanks BillyMac, much appreciated help.  There was no weight on path report, just measurements, but I think you must be pretty close.  I am pleased with the result anyway, seems to be fairly small tumor in my books..............Tks Nothard

Age 51yrs
DX 11/11/08
6 out of 8 cores positive 3 X 60% / 3 X 10%
PSA 4
Gleason 3+4=7
Stage T1c
Robotic Surgery 24/12/08
Upgrade Gleason 4+3=7 (60% Grade 4)
Stage T2c
Three small foci total volume 10%
Neg Margins and Nodes
Nil - Extraprostatic Extentions
Dry less than 1 week.
ED- taking Meds/ No results yet/still "NotHard"
PSA 28/1/09 0.03
PSA 24/2/09 0.03
"Everyday in Everyway I get better"

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