Outstanding Studies ~ Stage 3 guys please read

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Tony Crispino
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Date Joined Dec 2006
Total Posts : 8128
   Posted 5/20/2009 8:41 PM (GMT -6)   
Thanks to the webmaster at the Infolink ~ Mike Scott...(http://prostatecancerinfolink.net)
 
Thiis PubMed study from Sweden.  Stage 3b guys who underwent surgery/HT/RT have markedly better results after year ten.  I guessed right...
 
 
Tony


 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!

Post Edited (TC-LasVegas) : 5/21/2009 3:39:46 PM (GMT-6)


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 5/21/2009 7:55 AM (GMT -6)   
Tony,
Given my pathology results do you think that I should consider ADT even though my first PSA was <.1?
I guess RT will only be necessary if the PSA goes above .1
Age: 67
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
Dx 12/30/08
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09
Surgeon: Dr. Randy Fagin, Austin TX.
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Bilateral 10-20% involved
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx
Negative margins
seminal vesicles clean
Lymph nodes: not dissected
1st PSA test 4/7/09 result <0.1


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/21/2009 9:25 AM (GMT -6)   
You might print these results and bring them to your doctor. Your stage was included in this study. What they are saying is that it is better to act before recurrance than after. ADT was my least favorite treatment, but knowing what i now know, I have no regrets. My oncologist understands why I did what I did. He was against it at first, at least the part about adjuvant radiation, but he has changed his tune since. This tells me that the proactive approach is working well for us stage 3 guys. So does my PSA after surgery. It's been 26 months since a surgery with 4 positive margins, bilateral seminal vessicle invasion, and extra-prostatic extention than extended to the rectum and pelvic bone ~ and after adjuvant HT and RT a PSA that has remained undetectable. I have seen many guys start the climb in the first year with far better surgical results. How well this works after we stop the HT is still going to be interesting and nerve racking. But I believe in what we did.

Talk to your doctor...

Tony
 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


Doting Daughter
Veteran Member


Date Joined Aug 2007
Total Posts : 1064
   Posted 5/21/2009 9:30 AM (GMT -6)   
Good find Tony!! Fingers and toes are crossed!
Father's Age 62 (now 63)
Original Gleason 3+4=7, Post-Op Gleason- 4+3=7,
DaVinci Surgery Aug 31, 2007
Focally Positive Right Margin, One positive node. T3a N1 M0.
Bone Scan/CT Negative (Sept. 10, 2007)
Oct. 17 PSA 0.07
Nov. 13 PSA 0.05
Casodex adm. Nov 07, Lupron beg. Dec 03, 2007 2 yrs
Radiation March 03-April 22, 2008- 8 weeks 5x a week
July 2, 08 PSA <.02
Oct. 10, 08 PSA <.02
Praying for a cured dad.

Co-Moderator Prostate Cancer Forum


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/21/2009 9:31 AM (GMT -6)   
Yes, Chayna,
Your father is included and he took these steps.  Perhaps a Woo-Hoo?

Tony


 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/21/2009 3:48 PM (GMT -6)   
More studies and information is out today.  Adjuvant radiation is significantly better than salvage radiation for stage 3 guys.  If you are stage 3 after surgery and your doctor says wait until a rise in PSA before radiation, you might want to show him these studies...
 
From NCI...
 
From Germany ~ Registered with NCI:
 
It is becoming more clear that surgery with adjuvant RT, with or without HT is far better than RP or RT alone for the stage 3 patients.  The Swedish study above is including the HT in 3B cases with successes. 
 
Tony
 
 
 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


maldugs
Veteran Member


Date Joined Jun 2007
Total Posts : 784
   Posted 5/21/2009 5:37 PM (GMT -6)   
Good reading Tony, have had the RP & RT, maybe the HT next for me? we will see.

Regards Mal.
age 67 PSA 5.8 DRE slightly firm Rt
Biopsy 2nd July 07 5 out of 12 positive
Gleason 3+4=7 right side tumour adenocarcinoma stage T2a
RP on 30th July,

Post op Pathology, tumour stage T3a 4+3=7, microcsopic evidence of capsular penetration, seminal vessels, bladder neck, free of tumour, lymph nodes clear, no evidence of metastatic malignancy, tumour does not extend to the apical margins.

Post op PSA 0.5 26th Sept.

PSA 23rd Oct.0.5 seeing Radiation Onocologist 31st Oct.

Started radiation treatment on 5th Dec, to continue until 24 Jan. 08.
Finished treatment, next PSA on 30th April.
PSA 30th April 0.4
PSA 30th July 0.5
PSA 27th Oct 0.4 (I am now 68)
PSA 11th March 0.5

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