All About Hormone Therapy For Prostate Cancer

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

songwrangler
New Member


Date Joined May 2009
Total Posts : 3
   Posted 5/31/2009 9:25 PM (GMT -6)   
I am looking to dialog about side effects of taking Lupron in advance of beginning proton therapy. I have back and torso pains as well as groin discomfort not to mentin the hot flashes which are't bad at all ... but I am having to take increasing doses of pain medication for this pain. My questions have to do with is this normal. Have others experienced this? Thanks in advance for any information you might wish to post.

John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4269
   Posted 6/1/2009 10:16 AM (GMT -6)   
Songwrangler.
It would be helpful if you included your stats as that would gives us more information about the extent of your PC.
If you are just trying to shrink your prostate or delay the PC while you await proton treatments then Casodex and Proscar will do the job with out the side affects of Lupron. If your PC is more severe then Lupron or Zoledex is warrented. Also you might ask your doctor about high dose Casodex instead of Lupron.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DX BPH and continue to get biopsies yearly. Positive Biopsy in 10-08, 2 cores of 25, G6 less than 5%. Scheduled Surgery as recommended.

2nd Opinion from Dr Sholtz, an Oncologist said DX wrong, path shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G 4+3 approx 2.5cm diameter.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and burining urination. Daily activities resumed day after implants.

Scheduled for 5 weeks IMRT in July

JohnT


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 6/1/2009 12:32 PM (GMT -6)   
I agree with John,
Neo-Adjuvant HT is used in suspected advance cases. What was your diagnosis biopsy stats...?

Tony
 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


songwrangler
New Member


Date Joined May 2009
Total Posts : 3
   Posted 6/1/2009 2:32 PM (GMT -6)   

Hi ... thank for replys ... my PSA is 8.5 and gleason 9 ... radiation doc says lupron but no casodex ... I am mainly interested in those who have done this treatment prior to proton ... to find out if these side effects are normal or ??? ... thanks for the

 info ... I read that more extreme cases take both Lupron and Casodex so was happy that he just said Lupron ... but maybe this feeling is not justified ... anybody else care to comment ... I'm going to Loma Linda and have total confidence in everyone there so

 far ... they are super and have great attutudes which sort of rubs off ... plus great support groups ... and I love the proton BOB site ... but they don't have a forum there yet ... GBY&PTL ... db


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 6/1/2009 2:48 PM (GMT -6)   
How old are you?

So far the protocol sounds correct for the typical 64 year old and above at Dx.

Tony
 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


FRUSTRATED13
New Member


Date Joined Jun 2009
Total Posts : 4
   Posted 6/17/2009 6:20 PM (GMT -6)   
Did Lupron a couple of years ago have now started Zoladex pre IMRT. Hot flashes the worst offsetting with Bioflavanoids Quercitin and Hisperitin helping somewhat.. It seems caffeine and alcohol make hot flashes worse.

don826
Veteran Member


Date Joined May 2008
Total Posts : 1010
   Posted 6/17/2009 7:13 PM (GMT -6)   

Hello Songwrangler,

Prior to beginning my IMRT treatment I was put on lupron and casodex. The casodex was used to prevent a tumor "flare". As I understood it the "flare" could manifest as lower back and hip pain. The casodex was only for a month but the lupron is for two years.

I have had the usual SE's from the lupron but have adjusted.  I did have some muscle pain in my upper legs but began taking vitamin D and calcium. Also b12. Pain cleared up rapidly with the daily dose. I do not know if there is a cause and effect but it sure seemed to be one to me.

Good luck with the proton treatment.

Don 


Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones 
 
 
 


Hopeful in MD
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 6/17/2009 10:30 PM (GMT -6)   
Hi Songwrangler,

I have had one injection of Lupron, 30 Mg with only hot flashes for SE's. If you haven't advised your docs of the pain, you might want to consider it. Each of us responds differently to the PC drugs. My radiation oncologist rapped me twice in the middle of my back. When I asked why, he said that I would have jumped up in pain if the cancer had spread to my back. I sincerely hope that your pain is from the Lupron so that another drug or combination can be substituted. Also, I wish you the best with the proton therapy.
Hopeful in MD
Age 69.
Dx Dec 07. PSA 8.4. DRE confirmed tumor. Three of six biopsies positive. Gleason: 6 (3+3). Seed implants Iodine 125 Jan 08. PSA's 3.9, 1.7 after implants. Then rising PSA's: 2.3, 3.4, 3.9, indicating that seed therapy not working. Dr's decided to begin hormone injection therapy with Lupron 30 MG ea. 4 mos. First injection Apr. 21, 2009. So far so good. Slight fever and aches 2nd day after shot. Buttock soreness 2-3 days. Walking helped. Waiting for hot flashes etc. Hope they will be mild.  June - hot flashes vary in frequency and intensity but not a serious problem.  Feeling a lot of fatigue - not sure of cause.  Oncologist says that Lupron should not be the cause.  I wonder. 
 
Saw radiation oncologist Jun 17.  DRE negative for nodules - hooray!  He said that new guidelines  (believe contained in recent Urology journal - name unknown) call for 3 years of Lupron therapy instead of the previous protocol of 2 years  before stopping it.  Will check this out with my urologist next visit in Aug.
 
Began seeing psychologist Jun 4 for anxiety and depression (maybe from Lupron?).  Anxiety caused primarily by serious IBS (irritable bowel probs).  Doctor is using hypno-therapy for the IBS - talk therapy for anxiety on alternating weeks for each.  Also started Celexa for anti-anxiety / anti-depressant.  Think I made a smart decision to get help.  Recommend any of you who have difficulty coping with PC or other chronic conditions etc. get professional help.  For me, it is worth it.


riverbend
Regular Member


Date Joined Mar 2009
Total Posts : 39
   Posted 6/17/2009 11:25 PM (GMT -6)   
Songwrangler...You may want to post your question here: http://health.groups.yahoo.com/group/protoninfo/
 
I would bet that you'll find a few people who did hormone therapy followed by proton radiation there.
Dx T1c in April, 2009 at 45 years old after recent PSA tests ranged from 2.93-3.25
2 of 14 cores positive at 5% and Gleason 3+3... 2 cores taken from a "protuberance" were "ASAP"
Proton radiation at LLMC May-June 2009

New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, September 23, 2018 11:23 PM (GMT -6)
There are a total of 3,005,981 posts in 329,291 threads.
View Active Threads


Who's Online
This forum has 161814 registered members. Please welcome our newest member, thk.
218 Guest(s), 2 Registered Member(s) are currently online.  Details
sebreg, CatLady18