Psa rising added casadex

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kak
Regular Member


Date Joined May 2009
Total Posts : 85
   Posted 6/1/2009 9:18 AM (GMT -6)   
Hi:  Is there anyone out there with the same thing happening.  I had radiation and am presently on lupron , my psa went down from rad. treatment October 2007 until March of 2008 , than it increased from .3 to .7 and than 4 weeks late 1.54 and 4 weeks late 3.1.  Oncologist had added casadex.  Just wondering what anyone else experience has been
AGe 54 diagnosed March of 2007
PSA 107
Gleason 8
Stage T2 or T3 (weren't sure was out of prostate capsule)
Bone scan march 2007 and Aug 2008 both clear
ct 2007 clear
started casadex/lupron March of 2007 (casadex only for 4 months)(lupron for 2 yrs)
Aug 2007 had 37 treatments (also radiated lymph nodes)
psa spr 07-107,went down to .34 by Dec 08, March 09 0.7, May 1.54
 
 


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 6/1/2009 12:05 PM (GMT -6)   
"Casodex" might give a response and help, you would have to try it and see. Same thing can happen on casodex and in some bizarre cases casodex actually could feed PCa in some refractive patients at a given time in therapies. The Uro-docs don't use all the possible drugs in PCa arsenal, but a PCa onco-docs can and do, and knows many alternatives for you to try.

If you no longer get control by using Lupron and/or casodex then you should consider looking at many alternative drugs that can work (how long is always the question).
Ketoconazole, estradiol patches, DES, emcyt are some that are much less costly, different or less side effects and some of these cause direct apoptosis to PCa cells (always a plus).

There are actually scores of drugs used in the battle field on PCa, some combined too. Some you never heard of, but they are out there. At this point a patient should dump the uro-doc (if you are seeing one) and find an oncologist, whom is the correct specialist to see at this juncture.

Best to you 'keep your eyes on the road and hands upon the wheel' (as Jim Morrison would have said in Road House Blues)
 


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4227
   Posted 6/1/2009 2:54 PM (GMT -6)   
Ohio State,
If you take Femera with Casodex you won't get breast swelling or sensitivity. One of the good things about going to an oncologist rather than a urologist for hormone treatments is that they know all the tricks to reduce the side affects.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DX BPH and continue to get biopsies yearly. Positive Biopsy in 10-08, 2 cores of 25, G6 less than 5%. Scheduled Surgery as recommended.

2nd Opinion from Dr Sholtz, an Oncologist said DX wrong, path shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G 4+3 approx 2.5cm diameter.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and burining urination. Daily activities resumed day after implants.

Scheduled for 5 weeks IMRT in July

JohnT


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 6/1/2009 3:54 PM (GMT -6)   
kak,
Has your doctor prescribed any bone and CT/MRI scans? Casodex in 125mg doses may acheive a return to your nadir, but it's not a permanent fix. You may wish to look up HRPC and it's treatment protocols as any climb while on an LHRH agonist is likely refractory. Bob (zufus) can tell you an interesting story with DES and if the Casodex is ineffective it may be worth a shot to look into estrogenic alternatives. Another avenue is Ketocanazole, likely if your PSA jumps over 10. These are just some suggestions as I know your doctors know you status better than any of us. All the advice given in this thread is worth noting. You have my thoughts and prayers as well.

Peace to you and stay close.

Tony
 Age 46 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 6/1/2009 4:07 PM (GMT -6)   
Great advice from some wonderful minds in the fight against PCa. The only thing I can ad is this, be sure to take care of your mental, emotional, and spiritual self as you enter into a new phase of the journey. Cancer is a whole body disease and it is important that the whole body gets treated. I to pray you will have great success in whatever protocol you and your Oncologist choose. Your decision will be correct. Please know we all care and love you very much.

peace and grace
Dale
My PSA at diagnosis was 16.3
age 47 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes (3 positive) was 4+4=8
I had 44 IMRT's
Casodex
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11
PSA July 24th, 2008 is 0.04
PSA Dec 16th, 2008 is .016
PSA Mar 30th, 2009 is .02
Testosterone keeps rising, the current number is 156, up from 57 in May
T level dropped to 37 Mar 30th, 2009
cancer in 4 of 6 cores
92%
80%
37%
28%
 


kak
Regular Member


Date Joined May 2009
Total Posts : 85
   Posted 6/1/2009 8:20 PM (GMT -6)   
Have had bone scan summer of 2008 and ct about april 2007, before radiation all were clear. As of now going with casodex for 2 months as prescribed by oncologist and than going back to him to see how it has worked. If doesn't than I guess we cross that bridge when we come to it.

Thanks for all your well wishes. Cancer is a tough disease, but have a posative attitude, just hard sometimes when I get an ache or pain, especially in back, mind races and thinks has it spread, is it in the bones.
One day at a time, concentrating on posative thinking that the casodex will work. I knew when I was diagnosed that with such a high psa would be tough to treat. Have a caring oncologist and team that works with him, so I keep telling myself I have to trust him. It's just the what if's that are hard.

Good luck to everyone. I have a great spouse that keeps me going.
AGe 54 diagnosed March of 2007
PSA 107
Gleason 8
Stage T2 or T3 (weren't sure was out of prostate capsule)
Bone scan march 2007 and Aug 2008 both clear
ct 2007 clear
started casadex/lupron March of 2007 (casadex only for 4 months)(lupron for 2 yrs)
Aug 2007 had 37 treatments (also radiated lymph nodes)
psa spr 07-107,went down to .34 by Dec 08, March 09 0.7, May 1.54
 
 

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