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Regular Member

Date Joined Aug 2006
Total Posts : 148
   Posted 6/24/2009 5:41 PM (GMT -6)   
PARP Inhibitors. A better step in the right direction?

DX 8/24/06, Gleason 6, PSA 3.32, stage T1C
age 48 at the time, da Vinci on 10/20/06
Last PSA was ZERO
6/16/09 AdVance Sling installed

Post Edited (dawgfan) : 6/24/2009 4:58:06 PM (GMT-6)

Regular Member

Date Joined Sep 2008
Total Posts : 143
   Posted 6/26/2009 8:14 AM (GMT -6)   
Seems we are getting closer to finding the clues that will make PC a manageable disease, if not a cure altogether. I have seen three major breakthroughs in the last six months. Kudos to the researchers. This makes it easier for all of us to stay positive.
Age 61 (59 when Dx) PSA 4.4
Biopsy 5/15/08 Gleason (3+3=6)
Bone scan and pelvic CT: clear
HT - 2 mo Casodex, 3 mo Trelstar
RRP Surgery 9/15/08 La Mesa California
Post-OP Gleason 3+4=7, Stage pT2c pN0 MX
Seminal vesicals, perineural margin, 18 lymph nodes, bladder neck: all carcinoma free
Perineural invasion & Distal Margin: Carcinoma present
IMRT adjuvant radiation (35 Treatments) End 1/27/09
PSA (10/13/08): <0.1
PSA (3/13/09): <0.1

Regular Member

Date Joined Jan 2009
Total Posts : 71
   Posted 6/26/2009 1:08 PM (GMT -6)   
I was looking at the clinical trials for this and they indicate "solid tumor". Can someone please explain what this means? Does it mean one that has well-defined edges?
SO diagnosed 4/15/09 age 47
1/15/09=PSA 10
Dx 4/15/09=Right side= Gleason 4+4=7, 40% involved, 5 out of 6 cores positive, perineural invasion present
Left side+ Gleason 4+4=8, 60% involved, 5 out of 6 cores positive, no perineural invasion present
5/14/09=Robotic surgery at Cleveland Clinic by Dr. Gong
pre-op PSA 15, MRI shows extracapsular penetration
Pathology 5/21/09-T3a, N1MX, positive margins, 1 out of 13 lymph nodes positive, left nerves spared

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