Cure for Jewish Men

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mGamla
New Member


Date Joined Jul 2009
Total Posts : 4
   Posted 7/2/2009 2:22 AM (GMT -6)   
Some PCas in Jewish men are caused by a defective BRCA1 and BRCA2 gene. A new treatment (experimental) for this type of PCa seems to be "revolutionary", "groundbreaking", and a "holy grail". It is called PARP. According to the literature, the treatment does not work if you do not have the mutation, found mostly among Jews.  Anyone here being treated with this ? 
 
Here is the link:
http://seniorjournal.com/NEWS/Health/2009/20090625-PARP-Drugs.htm

Post Edited (mGamla) : 7/2/2009 1:53:07 AM (GMT-6)


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/2/2009 11:51 AM (GMT -6)   
Hi mGamla,
Welcome to HealingWell.  PARP inhibiters are making some headlines lately, but it still has a ways to go.  But I like this research.   In time having a genetic attack against prostate cancer just may lead to the vaccine or the cure.  But as stated in the blog below, we have a promising approach that needs for time to develop. 
 
For those looking for more info...PARP stands for “poly(ADP-ribose) polymerase...PARP from the infoLink blog...
 
Great post, mGamla.  And again welcome to a great support site...
 
Tony
 
 
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


mGamla
New Member


Date Joined Jul 2009
Total Posts : 4
   Posted 7/2/2009 2:58 PM (GMT -6)   
Thank you. Great forum. Sure science and medicine are always reversing themselves, but I think parp is a cure, right now, for those whose cancer was "caused" by defects from the Brca1 gene and Brca2 gene.
Based on my primitive "hearsay" layman's understanding, Brca1 and Brca2 produces defective cells, with an identifiable defect. Parp inhibitors exploit this defect only in those cells so affected, thereby killing only those defective cells.
 
The guarded optimism in the published reports seems to be substantially due to the fact that the parp inhibitors tested so far are only working, however dramatically, on individuals with the brca1 and Brca2 mutation, which is a small part of the total number of breast, ovarian and prostate cancer victims.
 
I have an interest because my mother, of Eastern European Jewish descent, developed ovarian cancer at 41 in 1976. It was at a very advanced stage. She is still alive, and in fact the only ovarian cancer survivor out of all those treated by her gynecological oncologist, according to what he told us.
 
Unfortunately the large amounts of radiation she was treated with severly damaged her hips, and she has suffered through nine hip surgeries. She has not been tested for the brca gene, but I am going to be, since my last psa at 52 was 3.4.
 
If I have PCa and brca I will do whatever  it takes to get that drug, even if it means going to England or another country for it.
 
I believe my mother is alive because we always obtained the best medical care available and always took control of her medical care by questioning and getting second and third opinions every time.
 
Case in point, we found the best hospital for her last hip surgery,  Hospital for Special Surgery, www.HSS.EDU and the results were dramatically better than her previous surgeries, even though it meant travelling for one month to Manhattan.
 
Incidentally,  the former PM of Israel, Olmert, chose that same Hospital group for his Prostate cancer surgery, even though Olmert had access to some of the world's best doctors and Hospitals in Israel. Olmert chose New York Presbyterian, affiliated with  Weill Cornell Medical college, the same is true for  Hospital for Special Surgery.
 
In fact, HSS and Presbyterian are next door to each other on 71 and York in the Upper East Side of Manhattan.

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/2/2009 4:01 PM (GMT -6)   
Actually,
Olmert had surgery at Memorial Sloan Kettering in Manhattan. He has a common friend with me. Dr. Arnon Krongrad in Miami is a prostate cancer surgeon in Miami. Krongrad also met with Olmert in Israel. I have worked with Arnon and I also represent one of his organizations ~ Prostate Cancer International. Mike Scott, who wrote the article I linked above, and Arnon are the co-founders of PCai.

Where this PARP stuff goes remains to be seen. In the study with prostate cancer there was only one noted case where the cancer was now completely undetectable. But, it's a start. Like you said, many won't benefit from where we are with this research, but it has more promise than other things I see out there. I also have a link to last years Scientific Retreat with a presentation on this research. All I can say is ~ keep it up guys!

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


mGamla
New Member


Date Joined Jul 2009
Total Posts : 4
   Posted 7/3/2009 3:02 AM (GMT -6)   
I am sure you are right about where the surgery took place , but I was told by someone at Presbyterian Hospital that the surgery took place there, under an alias. I believe that based in part on the article from Haaretz that would not name the Hospital for security reasons, but only quoted the press release from "Weill Cornell Medical college". This was after Haaretz said it would be done at Sloan Kettering a few weeks before. Also another article said his tests were to be performed at a different hospital than his surgery. I only thought the location was important because it might indicate a skilled surgeon affiliated with that Hospital (although that surgeon might be on staff at more than one).

Most of the Press, however, named Sloan Kettering, as you said.

http://www.haaretz.com/hasen/spages/1090455.html

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/3/2009 7:39 AM (GMT -6)   
Well,
When you start talking security for a Prime Minister, I don't know anything about that. I do know that MSK is one of the top 2 or 3 prostate cancer facilities in the country, if not the world. And both facilities have ties to Cornell. I also heard that Olmert is doing well.

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


mGamla
New Member


Date Joined Jul 2009
Total Posts : 4
   Posted 7/3/2009 1:40 PM (GMT -6)   
Do you know who his surgeon is , or can you find out ?

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/3/2009 9:16 PM (GMT -6)   
I don't see it anywhere. I could ask, but I'd bet the reason the surgeon is not named isn't by chance. When you mention MSK and surgery, there's only a couple that would be on top of the list assuming that they were MSK staff physicians...

tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


Geebra
Regular Member


Date Joined May 2009
Total Posts : 476
   Posted 7/4/2009 11:29 AM (GMT -6)   
From what I know, the best surgeon at MSK is Dr. James Eastam.

Father died from poorly differentiated PCa @ 78 - normal PSA and DRE

5 biopsies over 4 years negative while PSA going from 3.8 to 28

Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8

Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere+Avastin)

PSA prior to treatment on 1/8/2008 is 33.90, bounced on 1/31/2008 to 38.20, and down at the end of the treatment (4/24/2008) to 20.60

RRP at Duke (Dr. Moul) on 6/16/2008, Gleason downgraded 4+3=7, T3a N0MX, focal extraprostatic extension, two small positive margins

PSA undetectable for 8 months, then 2/6/2009-0.10, 4/26/2009-0.17, 5/22/2009-0.20, 6/11/2009-0.27

Salvage IMRT + 6 Months ADT: Casodex started 6/12/2009, Lupron 6/22/2009, PSA 6/25/2009-0.1, T=516, IMRT to start mid-Aug


KeyWestPirate
Regular Member


Date Joined May 2009
Total Posts : 60
   Posted 7/4/2009 6:17 PM (GMT -6)   

These posts emphasize what I have been saying since I began to post here:

Whatever your treatment decision, choose your treatment provider carefully.  Olmert clearly did.  You can too.

As long as we're naming surgeons, my (Da Vinci Robotic) was performed by Dr Todd Waldman in Boise, Idaho on Nov 23 of 2008.  I was dry the day after the catheter came out, and at seven months post op am finally capable without the pump.  I'm not going to throw it out just yet, these things come and go a bit, but it does look like I'm finally there.  I had some erectile capability immediately after the surgery, and Dr Waldmann cleared me to have intercourse 3 weeks post-op, but I was unable to achieve the rigidity and duration my wife needed without the pump until recently.  The pump DID work great, and I think that she is going to be sad to see it go :)
 
Dr Waldmann is a young surgeon, very enthusiastic, very positive about the robot, and very proud of his outcomes.  I'm VERY pleased to be another of his success stories.  He pushes the erectile rehabilitation concept from day one, suggesting some form of daily ED med starting immediately after surgery.  He also pushes the regular use of the VED, both for therapeutic as well as "functional" purposes.
 
This may read like SPAM, but it's a heartfelt acknowledgement of the skill and dedication of many of the surgeons out there. 
Still, had I stuck with my first urologist I would be wearing a diaper as I write this.
 
I still don't ejaculate, and until the "Jarvik Artificial Prostate Transplant" is perfected, I never will.  But, everything else seems to be there, just like it used to be.
 
This forum has been a great source of solid and throught-provoking information.  Thank you,   -all of you.

Post Edited (KeyWestPirate) : 7/4/2009 5:20:29 PM (GMT-6)


Geebra
Regular Member


Date Joined May 2009
Total Posts : 476
   Posted 7/5/2009 8:15 AM (GMT -6)   
KeyWestPirate,

I did name the MSK Dr., but my surgeon was Dr. Moul at Duke - also a very capable Dr. I live closer to MSK and my nephew is working there. He knows all the docs and recommended Dr. Eastham. I choose Duke because I was being treated there with Chemo and I liked a much more personal approach at Duke. Someone told me once that MSK is like a machine, excellent, but inpersonal. I am going for radiation there and I would agree with the assessment.

Greg B.

Father died from poorly differentiated PCa @ 78 - normal PSA and DRE

5 biopsies over 4 years negative while PSA going from 3.8 to 28

Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8

Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere+Avastin)

PSA prior to treatment on 1/8/2008 is 33.90, bounced on 1/31/2008 to 38.20, and down at the end of the treatment (4/24/2008) to 20.60

RRP at Duke (Dr. Moul) on 6/16/2008, Gleason downgraded 4+3=7, T3a N0MX, focal extraprostatic extension, two small positive margins

PSA undetectable for 8 months, then 2/6/2009-0.10, 4/26/2009-0.17, 5/22/2009-0.20, 6/11/2009-0.27

Salvage IMRT + 6 Months ADT: Casodex started 6/12/2009, Lupron 6/22/2009, PSA 6/25/2009-0.1, T=516, IMRT to start mid-Aug


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/5/2009 11:08 AM (GMT -6)   
Hi Greg,
You do point out a good message. You are right that some of the major centers can be production line like at times. I remember by step father getting lung cancer and going to MD Anderson as a last resort feeling the same way. He lost his battle as so many do with lung cancer, but he at least went to a center that was highly experienced and continued their recommendations with local care close to us. Since, I know of many others that visited MDA and wouldn't have it any other way. It is that high traffic volume that can hopefully help us not miss any opportunities in our treatment. But once a protocol is acceptable from those places, and it can be found closer to home, I fully understand staying close to home.

I believe the bast rout to treating prostate cancer is using the top line centers for advice and direction, and even treatment when needing a particular skill set, while still using these findings to get quality care closer to home where we can be close to loved ones.

Key West....LOLOL the Jarvik Prostate Prosthetic may be available soon in an "as seen on TV" ad near you...I was going to use my Billy Mays voice, but that poor guy just left us. I just don't do as good an impression of that guy with the headset always on...

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


mvesr
Veteran Member


Date Joined Apr 2007
Total Posts : 823
   Posted 7/5/2009 8:19 PM (GMT -6)   

Hi Geebra

 

Dr. Moul at Duke is my Dr. also.  He is a very experienced surgeon having retired from the Army at Walter Reed and is now at Duke.  He is very gifted and I had a very wonderful experience with the great people at Duke.  Now that I am two years out from open surgery things are going very well for me and now rather enjoy my follow up visits there.

 

Mika


age at dx 54 now 56
psa at dx 4.3
got the bad news 1/29/07
open surgery Duke Medical Center 5-29-07
never more than 2 pads
Tossed the pads this spring
ED still a problem
Got a shot last week and it was great
A year an a half of zero's
 

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