I don't feel I can venture any advice, but here is some info.
WRT Taxotere, I had the neo-adjuvant treatment and while everybody is different, I had very few side effects. Fatigue and mouth sores were major ones (and loss of some hair, of course). I never stopped working and kept my busy travel schedule (every week).
I was offered another neo-adjuvant option - Taxotere with hormones. In Stage II trials there were 2 people "cured" of cancer (after RRP they could not find any traces of the disease). Unfortunately for me, this was a randomized trial and I only had a 50% chance of getting the treatment. I chose Taxotere with Avastin.
The good news is that chemo works better with higher Gleason scores. I had G8 on biopsy and G7 after prostatectomy.
Best of luck!
Father died from poorly differentiated PCa @ 78 - normal PSA and DRE
5 biopsies over 4 years negative while PSA going from 3.8 to 28
Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8
Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere+Avastin)
PSA prior to treatment on 1/8/2008 is 33.90, bounced on 1/31/2008 to 38.20, and down at the end of the treatment (4/24/2008) to 20.60
RRP at Duke (Dr. Moul) on 6/16/2008, Gleason downgraded 4+3=7, T3a N0MX, focal extraprostatic extension, two small positive margins
PSA undetectable for 8 months, then 2/6/2009-0.10, 4/26/2009-0.17, 5/22/2009-0.20, 6/11/2009-0.27
Salvage IMRT + 6 Months ADT: Casodex started 6/12/2009, Lupron 6/22/2009, PSA 6/25/2009-0.1, T=516, IMRT to start mid-Aug