PSA from undetectable to .4 in 5 days?

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Regular Member

Date Joined Mar 2007
Total Posts : 422
   Posted 7/20/2009 3:03 PM (GMT -6)   
HW Friends,
Went in May 15 to reg uro. Psa was .07 (increase from .05 nine mo ago).  Went in last Monday for 1 yr implant check-up.  Psa was "undetectable" (less than .1: Lab said they changed where lowest their lowest reading is .1.
OK.  I went to my regular primary care doc  Friday for a six month check-up.  He wanted blood too, including psa.  It's ok with me but I'm thinking, "What a waste to re-take psa so quickly."  So Friday p.m., his nurse called and said blood work was all "normal".  I said, "I want the numbers."  She said psa was .4... and I hit the roof!  After giving her an education on what that high a reading meant for someone without a prostate glan who has had protate cancer, I told her to have the doc call me back asap.  She called back in 30 minutes saying the doc wanted me to go to my regular urologist asap.  She confessed he had not "signed off" on my labwork before she called me.  She seemed ignorant that someone like me with that reading could be in danger.  So I went this morning to my regular uro (he's not the one who removed my prostate) for another check and chat with my reg uro.  He gave another psa test.  I'll know that reading on Wednesday. 
My first thought was that I have psa readings from differfent labs now (soon to be 3), all within 8 days!  I expect some variation, right?  But from .07 to .4 in 4 or 5 days?  So I didn't concern myself too much until this morning when I visited my regular urologist.  He did say it's possible for a lab error, but he's actually seen that before, with a diagnosis of the cancer returning. 
Has anyone here ever had such a rapid change in psa readings?
PC diagnosed 12-06 @ age 63
Radical open removal 2-14-07, Gleason 3+3=6
Post-Surgery psa  -- .011
Removal of stricture 6-07, incontinence continues
01-15-08 psa -- .05
AUS, IPP implanted 07-16-08
AUS, IPP activated on 08-18-08.  They both work!
10-20-08 went back to surgeon for a follow-up.  Both devices work well.
10-20-08 psa -- .05
05-15-09 psa -- .07

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4269
   Posted 7/20/2009 3:10 PM (GMT -6)   
Using diffferent labs I used to get high variations within a week apart; sometimes as high as 10 points, but mostly in the 2-4 point range. This was with a psa of around 30, so I assume the same % difference would be true on the lower end.

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DX BPH and continue to get biopsies yearly. Positive Biopsy in 10-08, 2 cores of 25, G6 less than 5%. Scheduled Surgery as recommended.

2nd Opinion from Dr Sholtz, an Oncologist said DX wrong, path shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G 4+3 approx 2.5cm diameter.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and burining urination. Daily activities resumed day after implants.

Scheduled for 5 weeks IMRT in July


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