Interesting article published by Stephenson et al
out of the Cleveland Clinic, U Mich and Sloan-Kettering. Abstract at jco.ascopubs.org/cgi/content/abstract/JCO.2008.18.2501v1
and discussion at prostatecancerinfolink.net/2009/07/28/15-year-outcomes-after-radical-prostatectomy-a-new-predictive-model/#more-6527
Conclusions: Fifteen-year PCSM (Prostate Cancer Specific Mortality) and all-cause mortality were 12% and 38%, respectively. The estimated PCSM ranged from 5% to 38% for patients in the lowest and highest quartiles of predicted risk of PSA-defined recurrence, based on a popular nomogram (presumably the MSKCC Kattan Nomogram). Biopsy Gleason grade, PSA, and year of surgery were associated with PCSM....Neither preoperative PSA velocity nor body mass index improved the model's accuracy. Only 4% of contemporary patients had a predicted 15-year PCSM of greater than 5%.
For what it's worth. Alas, they want $22 to read the full article, so I'll have to wait until I get back to the States and can have interlibrary loan get me a copy.
Larry ShickPersonal homepage incl. PCa story: www.sv-moira.com
(age 60) biopsy PSA 4.4, free PSA 9%, T2c stage, Gleason 7 (3+4), 7 of 14 cores; 6'2", 200 lbs.03/09: Robotic surgery
(Dr. Kawachi, City of Hope) 47 gms, 10% involved, staging/Gleason unchanged (pT2cNXMX), margins clear, no ECE/sem ves involvement, fully continent from day 1, some success w/Viagra 50mg/day.Followup: 05/09 <0.01
Post Edited (CapnLarry) : 7/28/2009 1:34:32 PM (GMT-6)