Heavy Drinking Linked to Aggressive Prostate CA

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Kbars
Regular Member


Date Joined Jun 2009
Total Posts : 38
   Posted 7/29/2009 2:58 PM (GMT -6)   
I subscribe to a newsletter from the Prostate Cancer Foundation. I just got an e-mail from them of a study by the Fred Hutchinson CA Research Center - Alan Kristal that was in the July 13 issue of "Cancer". The study started out to test the effectiveness of the drugs Proscar, Propecia. Instead it was found that heavy drinking, especially when it is beer increases the risk for highly aggressive prostate cancer. Consumption also appears to undercut the effect of these cancer prevention drugs.
 
Has anyone else seen this study/article. That has to explain why I got PCA. I do love my beer! K-bars   

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/29/2009 3:57 PM (GMT -6)   
Hi Kbars,
This study is real. But it isn't conclusively the cause of aggressive prostate cancer. But it is a possible cause. I have seen many such studies that do say that there is a connection to prostate cancer with excessive drinking. I have also read that drinking in moderation, red wine is helpful in preventing or slowing prostate cancer progression. But as I always say, sometimes it's just bad luck, too. If there is family history, there is a strong likelyhood you can get prostate cancer no matter how much you drink. It's best to look forward, and that is what I do.

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4237
   Posted 7/29/2009 4:39 PM (GMT -6)   
And I always thought that it was Agent Orange, not the beer, that gave me my PC.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DX BPH and continue to get biopsies yearly. Positive Biopsy in 10-08, 2 cores of 25, G6 less than 5%. Scheduled Surgery as recommended.

2nd Opinion from Dr Sholtz, an Oncologist said DX wrong, path shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G 4+3 approx 2.5cm diameter.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and burining urination. Daily activities resumed day after implants.

Scheduled for 5 weeks IMRT in July

JohnT


goodlife
Veteran Member


Date Joined May 2009
Total Posts : 2691
   Posted 7/29/2009 4:42 PM (GMT -6)   
No family history and a tea totaler. Haevn't had more than 3 beers in my entire life.

Oh well, maybe it was too much sex !
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks due to anatomical issues with location of ureters with respect to bladder neck.  Try 3 tubes where no tubes are supposed to be for 2 weeks !
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)


geezer99
Veteran Member


Date Joined Apr 2009
Total Posts : 990
   Posted 7/29/2009 5:16 PM (GMT -6)   
goodlife

Or it may have been too little sex and not enough beer
Age at diagnosis 66, PSA 5.5
Biopsy 12/08 12 cores, 8 positive
Gleason 3+4=7
CAT scan, Bone scan 1/09 both negative.

Robotic surgery 03/03/09 Catheter Out 03/08/09
Pathology: Lymph nodes & Seminal vesicles negative
Margins positive, Capsular penetration extensive Gleason 4+3=7
6 weeks: 1 pad/day, 1 pad/night -- mostly dry at night.
10 weeks: no pad at night -- slight leakage day/1 pad.
3 mo. PSA 0.0 - now light pads


Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 7/29/2009 7:24 PM (GMT -6)   
I am only an occasional beer and red wine drinker (once a week, if that) and have been for a long time. Gleason 8.
Pre-op:
Age 63 at diagnosis, now 64.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores.
Operation:
Non-nerve sparing RRP on 7 March 2008.
Two nights in hospital; catheter out after 7 days.
Post-op:
Continent; no pads needed from the get-go.
Pathology showed organ confined and negative margins. Gleason downgraded to 4+4=8.
PSAs:
6-week : <0.05
7-month: <0.05
13-month: 0.07 (start of a trend?)
ED:
After a learning curve, Bimix injections (0.2ml) are working well. VED also works but we find it inferior to Bimix.


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 7/29/2009 7:27 PM (GMT -6)   
Me, haven't even had as much as a sip of beer in over 37 years, being "dry" didn't help me from PC, lol. Perhaps it was the too much sex part when I was younger.

David in SC
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, again
 
 


geezer99
Veteran Member


Date Joined Apr 2009
Total Posts : 990
   Posted 7/29/2009 9:23 PM (GMT -6)   
To OhioState
;
I would add 1000 IU of vitamin D. For bone strength -- as you get older your skin is less efficient at producing D and there are no food sources of it. Also think about the specialized eye vitamins -- may prevent macular degeneration. Keep your body mass index down and your activity up. Before you know it brother Dale will be sending out your thirty year zero pin. (just ignore the invoice that comes with it.)
Age at diagnosis 66, PSA 5.5
Biopsy 12/08 12 cores, 8 positive
Gleason 3+4=7
CAT scan, Bone scan 1/09 both negative.

Robotic surgery 03/03/09 Catheter Out 03/08/09
Pathology: Lymph nodes & Seminal vesicles negative
Margins positive, Capsular penetration extensive Gleason 4+3=7
6 weeks: 1 pad/day, 1 pad/night -- mostly dry at night.
10 weeks: no pad at night -- slight leakage day/1 pad.
3 mo. PSA 0.0 - now light pads


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 7/29/2009 9:30 PM (GMT -6)   
Ohio - i don't personally doubt your findings or research, but for the sake of conversation , my long term GP is opposed to your points 1-5. He is anti- supplements and vitamins in general, he opinion is that all people are really doing is making expensive urine. His opinion, not mine.
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, again
 
 


goodlife
Veteran Member


Date Joined May 2009
Total Posts : 2691
   Posted 7/29/2009 9:54 PM (GMT -6)   
Geezer,

I thought that caused calluses! ( Which I am in process of redeveloping )
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks due to anatomical issues with location of ureters with respect to bladder neck.  Try 3 tubes where no tubes are supposed to be for 2 weeks !
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/29/2009 11:17 PM (GMT -6)   
Here is another way of looking at heavy drinking and prostate cancer...We know PCa is slow in going. But many other cancers that are linked to drinking can be fast and decisive. Not to mention things like heart disease and addiction...No one should drink heavily...There are far more compelling reasons to only drink in moderation than linking PCa to it...

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/29/2009 11:25 PM (GMT -6)   
Here is another way of looking at heavy drinking and prostate cancer...We know PCa is slow in going. But many other cancers that are linked to drinking can be fast and decisive. Not to mention things like heart disease and addiction...No one should drink heavily...There are far more compelling reasons to only drink in moderation than linking PCa to it...

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Geason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


JoeyG
Regular Member


Date Joined Jul 2009
Total Posts : 162
   Posted 7/31/2009 8:07 AM (GMT -6)   
OhioState said...
" I only ask because our minds have to be open to new things, new concepts and treatment. You may need ADT 1, 2 or 3. GPs have no clue as to our plight my friend as well as many so called specialists in oncology, radiology or even urology-hematology. Just my opinion, but one has to be one's own advocate via much research and questioning."
I second that!
 
Here is a recent discussion with my GP and I ain't kidding:
 
GP: Well how's everything going since your cryo? What is your latest psa?
 
Me: Not really too well, it increased to 0.7.
 
GP: Oh, I wouldn't worry a bit, its still way below 4.
 
oh...and he graduated med school in 1988; so he is hardly anchient. oh and also, while I did have a positive DRE, his DRE came out "feels good to me>'
 
smhair  
 
I'm still waiting for him to send a prescription for a non-statin cholestral drug, as pomegranite and statins don't mix. In the meantime its fiber supplements, over-the-counter niacin and possibly a new GP.
***********************
 
By the way.....I don't know if its on this forum, but I remember a recent study that indicated that too much sex (including self indulgence) was a leading cause of PCa. And frankly, that, more than too much beer, makes a lot of sense.
 
 
Age -57; Diagnosed 10/05 PSA 13.4 GS 9 Organ confined (T2B)
Cryoablation 4/06 Allegheny Hosp-Dr Ralph Miller (Cohen/Miller)
Post Cryo Nadir 8/06 0.2
Rising steadily to 0.7 4/09 :-(
Steady at 0.7 (7/09) (Pomegranate???)
Looking to take next steps soon
Hoping to qualify for salvage cryo or radiation


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 7/31/2009 8:20 AM (GMT -6)   
Ohio, my GP and I have had a medical relationship for over 12 years, he is a good GP, and is the first to refer one to a specialist if anything is unusual or out of his league. He spends a lot of time with his patients in general, listens well, and gives one a sense of calm when dealing with him. Perfect? No way, but he's human too. He is the one over the years that didn't waste any time, and sent me to a variety of good specialists when needed. My file with him must be as thick as the NYC Yellow Page Book, lol, but he knows me, my mindset, and my body pretty well over the years. I feel fortunate to have him. He changed practices two or three years ago, and from what I was told, virtually 100% of his patients followed him and transfered their records to his new practice.
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, again
 
 

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