Atypical small acinar proliferation ASAP

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hjklop0
New Member


Date Joined Jul 2009
Total Posts : 1
   Posted 7/30/2009 10:48 AM (GMT -6)   
I have a diagnosis of ASAP Atypical small acinar proliferation on the right lobe of my prostate. I am 54 years old.
A triple immunostain shows absence of basal cells (p63 and 34BE12 negative) and weak luminal AMACR staining.
Can anyone tell me:
1- what is p63 and 34BE12 negative??
2-weak luminal AMACR staining.??
3- absence of basal cells??

Thanks for your answers.

Post Edited (hjklop0) : 7/30/2009 9:53:22 AM (GMT-6)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 7/30/2009 11:30 AM (GMT -6)   
Welcome here at HW, jjklop0. Wow, those are some questions, hopefully someone will come along soon and be able some or all of them. It's over my head, but glad you found us here.

David in SC
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, again
 
 


jacketch
Regular Member


Date Joined Apr 2009
Total Posts : 179
   Posted 7/30/2009 12:40 PM (GMT -6)   
For those answers I would want to hear directly from my physician. Ask him/her, you can just call.
62yo
V10.46 Dx Feb-09
RRP 5-5-09
No adverse SE
PSA 6-19-09 -0-
 
Thriving, not just surviving!
 


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4848
   Posted 7/30/2009 12:54 PM (GMT -6)   

"In urologic pathology, atypical small acinar proliferation, abbreviated ASAP, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant.

ASAP, generally, is not considered a pre-malignancy, or a carcinoma in situ; it is an expression of diagnostic uncertainty,[1] and analogous to the diagnosis of ASCUS (atypical squamous cells of undetermined significance) on the Pap test." http://en.wikipedia.org/wiki/Atypical_small_acinar_proliferation

Tried to Google the other two....Call your Doc as the others have suggested.


Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


LV-TX
Veteran Member


Date Joined Jul 2008
Total Posts : 966
   Posted 7/30/2009 1:09 PM (GMT -6)   
Sorry...had to jump in

AMACR - Alpha-Methylacyl Coenzyme A Racemase

This is a gene that gets elevated with Prostate Cancer. Typically it supports the ASAP as a benign rather than cancerous tissue. If the staining was elevated then the pathologist could possibly have indicated low grade carcinoma rather than ASAP.

Basel cell cancers are rare in the prostate and are not hormone driven type of cancers. However their appearance can be troubling when noted.

But ask your doc, he will explain it much better than any of us here.
You are beating back cancer, so hold your head up with dignity
 
Les
 
Age 58 at Diagnosis
Oct 2006 - PSA 2.6 - DRE Normal
May 2008 - PSA 4.6 - DRE Normal / TRUS normal
July 2008 - Biopsy 4 of 12 Positive 5 - 30% Involved Bilateral w/PNI - Gleason (3+3)6 Stage T1C
Robotic Surgery Sept 18, 2008
Pathology October 1, 2008 - Gleason 7 (3+4) Staged pT2c NO MX - Gland 50 cc
Seminal Vesicles and Lymph Nodes clear
Positive Margins Right Posterior Lobe
PSA 5 week Oct 2008 <.05
                   3 month Jan 2009 .06
                   6 month Apr 2009 .06
                   9 month Jul  2009 .08


huey
Regular Member


Date Joined Jul 2009
Total Posts : 27
   Posted 7/30/2009 8:07 PM (GMT -6)   
http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043%2F1543-2165(2006)130%5B952:ASAPIT%5D2.0.CO%3B2

This web site might help.

It's from Dr.Bostwick of Bostwick Lab in Virginia.

Good Luck
Age: 64
Dx: 6/2/09, Age 63
G: 3+3
PSA: 2.04
Samples: 12, 1PC, 20%
DRE:positive
Stage: t2a
Still trying to decide on treatment.

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