Continuing Injections after being diagnosed with Peyronies Disease

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hb2006
Regular Member


Date Joined Nov 2008
Total Posts : 299
   Posted 8/19/2009 12:11 PM (GMT -6)   
I started Caverject Injections in Sept of 2008 and switched to Trimix in March of 2009. Then at the end of June, 2009; I was diagnosed with Peyronies Disease. My urologist did not tell me to stop the Trimix Injections but I'm curious to hear of any other's experiences.
 
On the PD Forums, alot of guys swear that the injections caused the Peyronies. But there really has not been a determination of what causes it. At this point I'm using a Three Tube VED with a daily protocol for the treatment of PD. It's too early to tell if the scarring is receding or not.
Age 60, PSA 2007 4.1, PSA 2008 10.0
Diagnosed April 2008, Biopsy: 6 of 12 cores positive, Gleason 4 + 5 = 9
CT and Bone Scan negative, Open surgery at Shawnee Mission Medical Center May 21, 2008
Right side nerves spared, Radical prostatectomy and lymph node dissection
Cather removed on June 3rd, totally dry on July 9th, pT2c, lymph nodes negative
PSA Sept 28, 2008 0.00, PSA Jan 22, 2009 0.00, PSA June 29, 2009 0.00
ED Status- Currently using Trimix, Levitra daily for increased blood flow.
Noctural Erections have completely returned on a nightly basis, same hardness as before.


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4849
   Posted 8/19/2009 12:34 PM (GMT -6)   
For those like me that don't know:
 
Peyronie's disease (also known as "Induratio penis plastica"[1]) is a connective tissue disorder involving the growth of fibrous plaques[2] in the soft tissue of the penis affecting as many as 1-4% of men. Specifically the fibrosing process occurs in the tunica albuginea, a fibrous envelope surrounding the penile corpora cavernosa causing an abnormal curvature of the penis.
 
Peyronie's Disease is also formally known as "penile induration" or "Induratio Penis Plastica (IPP)" and colloquially as "bent nail syndrome". A French surgeon, Fran├žois Gigot de la Peyronie, first described the disease in 1743.
http://en.wikipedia.org/wiki/Peyronie's_disease
 
Does your Uro remember you're on Trimex? I wouldn't take anything without asking first.
Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


hb2006
Regular Member


Date Joined Nov 2008
Total Posts : 299
   Posted 8/19/2009 12:43 PM (GMT -6)   
Wikipedia needs to be updated. The latest estimates are that it really affects about 10% of all men 24 and above. There are at least 4 or 5 web sites, forums dedicated to PD.

Yes, after he diagnosed it, he gave me a refill for the Trimix. My concern is because of all the warnings on the Caverject and Edex web sites. Those web sites say to stop doing injections if you start to have a curvature.
Age 60, PSA 2007 4.1, PSA 2008 10.0
Diagnosed April 2008, Biopsy: 6 of 12 cores positive, Gleason 4 + 5 = 9
CT and Bone Scan negative, Open surgery at Shawnee Mission Medical Center May 21, 2008
Right side nerves spared, Radical prostatectomy and lymph node dissection
Cather removed on June 3rd, totally dry on July 9th, pT2c, lymph nodes negative
PSA Sept 28, 2008 0.00, PSA Jan 22, 2009 0.00, PSA June 29, 2009 0.00
ED Status- Currently using Trimix, Levitra daily for increased blood flow.
Noctural Erections have completely returned on a nightly basis, same hardness as before.


lifeguyd
Veteran Member


Date Joined Jul 2006
Total Posts : 686
   Posted 8/19/2009 1:24 PM (GMT -6)   
When I was using Caverject (100% alprostadil)  I had a pronounced curve to the right.  The doctor never called it Peyronis but was concerned.  I quit using Caverject because of the discomfort and went to bi-mix (no alprostadil)  and most of the curve went away.  I have always had a little curve to the right, so I don't think the injection has had much to do with it.  However, I find that if I use a lot (more than 40mcg)  I tend to have a harder erection and more curve.  I now use 25 to 30 mcg with good success and fewer problems.

PSA up to 4.7 July 2006 , nodule noted during DRE
Biopsy 10/16/06 ,stageT2A
Very Aggressive Gleason 4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8 with no extension or invasion
no long term continence problems
Post surgery PSA continues to be "undetectable"
One side nerves spared
Bi-Mix for ED 
born in 1941


brainsurgeon
Regular Member


Date Joined Jul 2009
Total Posts : 137
   Posted 8/20/2009 2:57 AM (GMT -6)   
I first noted my Peyronie's disease at about age 28 (now 70). I knew there was no real treatment of proven worth, went on with my life, had two kids, had a nice sexual life, and no problems as it became quiescent. Then at about age 60, I had a painful and acute episode leaving me with more angulation. This too resolved and allowed sexual intercourse. Of some interest (and reported by others also) was the fact that a Dupuytren's contracture in my right hand went away after being present for some years. Now, I am thinking about starting penile injections for ED presumed from my prostatectomy and wonder what other's experiences have been with Peyronie's and injections.
70 years old USA citizen
Prostatic carcinoma dxed June 2009 by PSA (7.0) and then Bx
PSAs yearly since 2001 ranged 1.52 to 7.0
Neg. CT and BS
4 of 8 biopsies positive (all right side) Gleason Score 3+4=7
Robotic assisted total prostatectomy and node excision July 2009 in Luzern, Switzerland
pT2c G3 pN0 (0/14)
Catheter out in 5 days (home in 3 days)
No incontinence
Potency: beginning tumescence??? at 3 weeks post-op

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