Lupron Injection Causing body ache / flu symptoms?

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Hopeful in MD
Regular Member

Date Joined Apr 2009
Total Posts : 66
   Posted 8/23/2009 7:40 PM (GMT -6)   
Hi All,
I just had my 2nd Lupron shot - 30 Mg /4 mos.  With the first, I had some flu-like symptoms.  This time, they seem to be worse.  Taking Tylenol for discomfort. 
Any one on HT with Lupron have such symptoms?
Gene in Md
Hopeful in MD
Age 70.
Dx Dec 07. PSA 8.4. DRE confirmed tumor. Three of six biopsies positive. Gleason: 6 (3+3).
Seed implants Iodine 125 Jan 08.
PSA's 3.9, 1.7 after implants. 
Rising PSA's: 2.3, 3.4, 3.9, indicating  seed therapy not working. 
April 09 began hormone injection therapy with Lupron 30 MG ea. 4 mos.  Side effects - hot flashes, about 1 an hour, initial severe fatigue. Gone as of mid-July.
Jun 09 - Oncologist DRE negative for nodules - hooray!!!
Aug 09 - PSA 0.5!!!  Lupron is working! 
Began seeing psychologist Jun 09 for anxiety and depression.  Anxiety from serious IBS (irritable bowel) probs.  Doctor using hypno-therapy for the IBS - talk therapy for anxiety.   Recommend anyone having difficulty coping with PC or other chronic conditions etc. get professional help. 

Veteran Member

Date Joined Apr 2008
Total Posts : 1382
   Posted 8/24/2009 6:47 PM (GMT -6)   
Lupron was tough on me to at first. Course I was going through 44 rounds of IMRT at the time and just coming off unsuccessful surgery. After several months being on it I did get use to it. It takes a few days for the soreness to go when you have the shot.
How long will you be on HT?

peace to you
My PSA at diagnosis was 16.3
age 47 (current)

My gleason score from prostate was 4+5=9 and from the lymph nodes (3 positive) was 4+4=8
I had 44 IMRT's
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11

PSA July 24th, 2008 is 0.04
PSA Dec 16th, 2008 is .016
PSA Mar 30th, 2009 is .02
PSA July 28th 2009 is .01

Testosterone keeps rising, the current number is 156, up from 57 in May

T level dropped to 37 Mar 30th, 2009
cancer in 4 of 6 cores

Steve n Dallas
Veteran Member

Date Joined Mar 2008
Total Posts : 4848
   Posted 8/25/2009 5:13 AM (GMT -6)   
Lupron side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Lupron: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
bone pain;
swelling, rapid weight gain;
pain, burning, stinging, bruising, or redness where the medication was injected;
feeling like you might pass out;
painful or difficult urination;
urinating more often than usual; or
sudden headache with vision problems, vomiting, confusion, slow heart rate, weak pulse, fainting, or slow breathing.
Rare but serious side effects may include:

pain or unusual sensations in your back;
numbness, weakness, or tingly feeling in your legs or feet;
muscle weakness or loss of use; and
loss of bowel or bladder control.
Less serious Lupron side effects may include:
acne, increased growth of facial hair;
dizziness, weakness, tired feeling;
hot flashes, night sweats, chills, clammy skin;
nausea, diarrhea, constipation, stomach pain;
skin redness, itching, or scaling;
joint or muscle pain;
vaginal itching or discharge
breast swelling or tenderness;
testicle pain; impotence, loss of interest in sex;
depression, sleep problems (insomnia), memory problems; or
redness, burning, itching, or swelling where the shot was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.

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