Options Post-Surgery, High PSA

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New Member

Date Joined Aug 2009
Total Posts : 1
   Posted 8/27/2009 10:39 PM (GMT -6)   
Hello everyone,

I'll make it short. Gleason of 7 or 8... Had surgery, seemed okay (no lymph nodes spread, and margins were negative), but it must have escaped because of a rising PSA after surgery. PSA before surgery was about a 22. After surgery it was a 22, 25, 35.

On Hormone Therapy now. Bone scans and other scans came back negative.

Every doctor we've seen says its aggressive (because of the timetable of the rising PSA was really steep).

Does hormone therapy really last 6months-5 years? Anyone have any experience with Provence or AstraZeneca's drug in clinical trials? Is it easy to get into the clinical trials? Anyone have experience with DCA?
Those three have been the ones that I've read about the most on the internet.

Sorry for it being long,


Veteran Member

Date Joined Nov 2006
Total Posts : 1464
   Posted 8/28/2009 8:45 PM (GMT -6)   
Hey MrGreek,

I'm not in your treatment boat but wanted to bump this up so you get an answer before it falls off the page. The are several guys on hormone therapy here and they will probably get on your case.

Good luck and please stay with us, we can all get well together.

Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06. Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + .04 cc Trimix = Excellent Results
PSAs from 1/3/07 - 7/17/09 zero.
Next PSA - July/2010
Lung cancer dxed on 5/16/08. Surgery on 6/25/08 T1N1M0 - Stage IIA Finished 4 cycles of chemo on 11/7/08.
CT scans on 12/2/08 - 6/25/09 - in remission!!!
Next scan in September 09.
Biker90's Journey
"Patience is essential, attitude is everything."

Regular Member

Date Joined May 2009
Total Posts : 476
   Posted 8/28/2009 9:45 PM (GMT -6)   
I have an answer to just one of your questions. If you meet eligibility criteria, it is easy to get into clinical trial. I was advised about two different ones, but upon closer examination was only eligible for one of them. Even my doc was surprised about the fine print. (It was the amount of time from the last biopsy). Big centers, like Hopkins, Dana Farber, Sloan Kettering have a bigger selection of trials, but you can look at cancer.gov site for a listing.

I am sure others will be able to answer more of your questions.

Father died from poorly differentiated PCa @ 78 - normal PSA and DRE

5 biopsies over 4 years negative while PSA going from 3.8 to 28

Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8

Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere+Avastin)

PSA prior to treatment on 1/8/2008 is 33.90, bounced on 1/31/2008 to 38.20, and down at the end of the treatment (4/24/2008) to 20.60

RRP at Duke (Dr. Moul) on 6/16/2008, Gleason downgraded 4+3=7, T3a N0MX, focal extraprostatic extension, two small positive margins

PSA undetectable for 8 months, then 2/6/2009-0.10, 4/26/2009-0.17, 5/22/2009-0.20, 6/11/2009-0.27

Salvage IMRT + 6 Months ADT: Casodex started 6/12/2009, Lupron 6/22/2009, PSA 6/25/2009-0.1, T=516, 7/23/2009-<0.05, T<10, IMRT to start mid-Aug

Veteran Member

Date Joined May 2009
Total Posts : 2692
   Posted 8/28/2009 10:30 PM (GMT -6)   
One of the prob;ems with some trials is that you may not get the treatment. Ususally they divide the group and some get the treatment being tested and some don't. You can go to clinicaltrials.gov, or something like that to see what is available.

It would help if you could put your surgical pathology in your signature. That gives a better idea of how to answer.

Good luck and welcome to the forum.
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks due to anatomical issues with location of ureters with respect to bladder neck.  Try 3 tubes where no tubes are supposed to be for 2 weeks !
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)

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