2 labs different reading

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maldugs
Veteran Member


Date Joined Jun 2007
Total Posts : 789
   Posted 8/30/2009 8:27 PM (GMT -6)   
Hi everyone, my last PSA was 0.6 from the same lab we have been using for 2 years, last week I had a random PSA frm the lab my GP uses and it came back 0.68, my GP is on holiday, was wondering if anyone knows the rule the second lab uses?

Regards Mal.
age 67 PSA 5.8 DRE slightly firm Rt
Biopsy 2nd July 07 5 out of 12 positive
Gleason 3+4=7 right side tumour adenocarcinoma stage T2a
RP on 30th July,

Post op Pathology, tumour stage T3a 4+3=7, microcsopic evidence of capsular penetration, seminal vessels, bladder neck,are free of tumour, lymph nodes clear, no evidence of metastatic malignancy, tumour does not extend to the apical margins.

Post op PSA 0.5 26th Sept.
PSA 23rd Oct.0.5 seeing Radiation Onocologist 31st Oct.
Started radiation treatment on 5th Dec, to continue until 24 Jan. 08.
Finished treatment, next PSA on 30th April.
PSA 30th April 0.4
PSA 30th July 0.5
PSA 27th Oct 0.4 (I am now 68)
PSA 11th March 09 0.5
PSA 3rd Augiust 09 0.6


TheoTeacher
Regular Member


Date Joined Jul 2009
Total Posts : 47
   Posted 8/30/2009 9:14 PM (GMT -6)   
I have been told by two doctors to use the same lab if possible.  Different labs use different methodologies.  My PSA report always states what method was used to obtain the reading, such as the Dade Behring Enzyme Immunoassay methodology.  Also, to go from .6 to .68 may not indicate a trend but simply a difference in test methods.
I guesee your uro will clear it up for you.
Dad dx at 72 with Pca; RP at 73; Died 11/08 at 88 from Pca met.
3 Uncles have had Pca; 2 deceased from Pca met.
Me: Age 51: Joyfully Married; father of 7!
Routine Physical 11/07 PSA 1.73 DRE normal
Routine Physical 1/09 PSA 2.77 DRE abnormal.
1st Urologist visit 2/09 DRE normal, small - PSA 6.3!
Biopsy 3/17- St. Patty's Day! 3 of 12 cores positive with 5-8% Pca
3+3 Gleason; Visit Johns Hopkins 3/26/09 and decide for surgery.
Lapro RP 6/29/09; discharged 6/30/09
Cath out 7/9/09 Gleason unchanged 3+3;
"Larger amount of cancer" than expected.
Organ confined Pca, positive margin as "artifact" of surgery.
All other tissues clear.
7 wk psa 8/20/09 - 0.05

"We walk by faith, not by sight."


maldugs
Veteran Member


Date Joined Jun 2007
Total Posts : 789
   Posted 8/30/2009 9:47 PM (GMT -6)   
Hi Theo, the second lab report says PSA result obtained using a third generation PSA assay on the Immulite 2500 (sensitivity 0.03 ug/L)

Will ring my Uro later, thanks for the reply.

Mal.
age 67 PSA 5.8 DRE slightly firm Rt
Biopsy 2nd July 07 5 out of 12 positive
Gleason 3+4=7 right side tumour adenocarcinoma stage T2a
RP on 30th July,

Post op Pathology, tumour stage T3a 4+3=7, microcsopic evidence of capsular penetration, seminal vessels, bladder neck,are free of tumour, lymph nodes clear, no evidence of metastatic malignancy, tumour does not extend to the apical margins.

Post op PSA 0.5 26th Sept.
PSA 23rd Oct.0.5 seeing Radiation Onocologist 31st Oct.
Started radiation treatment on 5th Dec, to continue until 24 Jan. 08.
Finished treatment, next PSA on 30th April.
PSA 30th April 0.4
PSA 30th July 0.5
PSA 27th Oct 0.4 (I am now 68)
PSA 11th March 09 0.5
PSA 3rd Augiust 09 0.6


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 8/31/2009 10:00 AM (GMT -6)   
mal, as you indicate, it's all in the generation test used. If you have a true PSA of .68, a 2nd gen will report results rounded to .6, where a 3rd gen will give a .68. The older 1st gen test would report it as less than .1 if it was the same .68. So it's all in the testing. As it is, it is all very small amounts, so statistically any deviation in the procedure, such as calibration, method of getting sample, etc, will affect the result. That's why the docs want to use the same labs all the time, to be consistent.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
22 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix 30/1/20-.05ml 2X week continues
PSA's: .04 each test since surgery


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 8/31/2009 10:35 AM (GMT -6)   
Hi Mal,
I wouldn't get to caught up in the test generations. Certainly whenever possible try to get it from the same lab each time. No need for uneccessary worry...

I hope you are well...Spring is on the corner for you, time to get tuned up for the Lawn Bowls?

Tony
 Age 47 (44 when Dx)
Pre-op PSA was 19.8 : Surgery at The City of Hope on February 16, 2007
Gleason 4+3=7, Stage pT3b, N0, Mx
Positive Margins (PM), Extra Prostatic Extension (EPE) : Bilateral Seminal vesicle invasion (SVI)
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 11, 2009): <0.1
 
My Journal is at Tony's Blog  
 
STAY POSITIVE!


maldugs
Veteran Member


Date Joined Jun 2007
Total Posts : 789
   Posted 8/31/2009 8:24 PM (GMT -6)   
Thanks guys, will stick to same lab in future, less confusing, yes Tony, getting fired up for the upcoming competition season.

Regards to all, Mal.
age 67 PSA 5.8 DRE slightly firm Rt
Biopsy 2nd July 07 5 out of 12 positive
Gleason 3+4=7 right side tumour adenocarcinoma stage T2a
RP on 30th July,

Post op Pathology, tumour stage T3a 4+3=7, microcsopic evidence of capsular penetration, seminal vessels, bladder neck,are free of tumour, lymph nodes clear, no evidence of metastatic malignancy, tumour does not extend to the apical margins.

Post op PSA 0.5 26th Sept.
PSA 23rd Oct.0.5 seeing Radiation Onocologist 31st Oct.
Started radiation treatment on 5th Dec, to continue until 24 Jan. 08.
Finished treatment, next PSA on 30th April.
PSA 30th April 0.4
PSA 30th July 0.5
PSA 27th Oct 0.4 (I am now 68)
PSA 11th March 09 0.5
PSA 3rd Augiust 09 0.6


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 8/31/2009 9:09 PM (GMT -6)   
Hello Mal,

I too agree with the other's postings sentiments. The years that my psa was being checked by my GP, we used his lab only, which went down to .10 only. Once he turned me over to the urologist, been using his lab ever since, and they go down to .01. Sticking to one lab does cut down some psa anixiety. Best to you, brother.

David in SC
 Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/9 .16
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, 8/14 met with Rad Oncl, 8/18 - laser scope surgery to clear blockage, now on Cath #7, 8/26 - cath removed
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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