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Oncas
Regular Member


Date Joined Jan 2009
Total Posts : 390
   Posted 9/10/2009 5:01 AM (GMT -6)   
Any news on the Provenge front? As you can see by my profile my future looks pretty dicey.
Hoping I can hang around awhile.
 
Jim

Age 61
Northeastern Penna.
11/08/08 annual checkup (3 yrs late) PSA 8.04 from previously 2.7 in 11/05
1/23/09 biopsy 12 cores positive, 10 cores Gleason 7, 2 cores Gleason 8 70% tumor
2/06/09 cat +bone scans clean ..
3/26/09 RRP surgery Post op path .. upgraded to Gleason 9 (5+4), seminal vesicles involved, several positive margins, 2 of 9 lymph nodes positive.
80% involved
4/4/09 Dr. advising wait for significant rise in PSA and initate hormonal treatment.
1st post op at 4 weeks PSA  .6  urologist concerned
will retest in one month
8/15/09  bone and pelvic scans redone .. clean   PSA .65
onc/radiologist recommending starting radiation treatments and 6 month shot of Lupron
9/11/09  consulting with med/onc today
 


JoeyG
Regular Member


Date Joined Jul 2009
Total Posts : 162
   Posted 9/10/2009 8:12 AM (GMT -6)   
Oncas,
 
Dendreon's re-application with the FDA for Provenge (labeled use-for hormonal refractory PCa) is still on schedule to be submitted late 2009/early 2010. It is expected that the FDA will approve Provenge shortly therafter.
Age -57; Diagnosed 10/05 PSA 13.4 GS 9 Organ confined (T2B)
Cryoablation 4/06 Allegheny Hosp-Dr Ralph Miller (Cohen/Miller)
Post Cryo Nadir 8/06 0.2
Rising steadily to 0.7 4/09 :-(
Steady at 0.7 (7/09) (Pomegranate???)
Looking to take next steps soon
Hoping to qualify for salvage cryo or radiation


Amy41
Regular Member


Date Joined Jan 2009
Total Posts : 30
   Posted 9/10/2009 12:25 PM (GMT -6)   
Thanks for the update - when I told one of my friends that works in the bio technology world about my husbands condition of advanced prostate cancer - the first word out of her mouth was provenge - I told her it was back burnered still. But I thought that was a good thing that she was in the know on the drug in the industry. So cheers for Provenge - lets keep our fingers crossed for approval and that it is the wonder drug that can help some of the guys.

JoeyG
Regular Member


Date Joined Jul 2009
Total Posts : 162
   Posted 9/10/2009 1:22 PM (GMT -6)   
Amy,
 
It may not be the wonder drug but it promises to be better than Taxotere (chemo) at about the same cost, with only a day or two of discomfort.
 
The trials for Provenge will continue after the label usage is approved, including a present trial directed for using Provenge to abate hormone-dependant PCa.
 
The thing that should be stressed with Provenge is that it will be the first approved therapy for prostate cancer that directs the immune system to specifically hunt and attack pca cells. There is so much hope that such therapies, when perfected, could potentially control PCa, as well as most other cancers for a lifetime. 
 
BTW: the main difference with Provenge 2009 vs Provenge 2006 is that the developers have found that booster shots enhance the immune system's continued attack on the cancer. However, at some point, that attack eventually subsides, even with the boostering.  
Age -57; Diagnosed 10/05 PSA 13.4 GS 9 Organ confined (T2B)
Cryoablation 4/06 Allegheny Hosp-Dr Ralph Miller (Cohen/Miller)
Post Cryo Nadir 8/06 0.2
Rising steadily to 0.7 4/09 :-(
Steady at 0.7 (7/09) (Pomegranate???)
Looking to take next steps soon
Hoping to qualify for salvage cryo or radiation

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