Hello Old Sailor,
The significance of the Gleason score is that it is a measure of the aggressiveness of the cancer. Higher score equals more aggressive. The more aggressive the cancer the more likely that there is or may be metastasis. Metastasis may be too small to pick up by CT or bone scans at an early stage. I had at least one doctor tell me that in my case it was highly likely that there was micro metastasis. This was due to my high PSA value coupled to the high Gleason. If you are familiar with the Parton tables and you have your numbers you can go the Sloan Kettering site and plug in the data and see what the difference is for your case versus a hypothetical case. Case 1. CS 4+4, PSA 5.0 Case 2. Gleason Score 3+3, PSA 5.0.
Do a google search on Gleason Score and Prostate cancer and you will get far better and more detailed information than I have given here.
Best wishes for a rising tide and a fair wind.
Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones
PSA 06/09 .36 or .30 depending on who did the test