CYMBALTA (duloxetine)

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jerseycity
Regular Member


Date Joined Nov 2008
Total Posts : 123
   Posted 11/8/2009 12:21 PM (GMT -6)   
at my 1 year doctor visit I was discussing my lingering leakage issue. I asked if there were any medication that might help. He suggested Cymbalta. He said it had shown some success with incontinence in wemon.  We discussed side effects also. Based on side effects and the fact that I do not want to be on some medication forever I have not been taking it. Has anyone heard of or taken this with any success.
 
I have been going commando at home on weekends trying to convince my brain that there is no protection down below. When just sitting around or when sleeping I am totally dry anyway so that has been hard to tell if it is going in right direction. When I am active it is a
problem.
 
Has anyone heard of any studies that show succes after a year with lekage. I know I have pushed this thread but it is a ongoing problem for me.
 
 3-17- 8 went to Bruce Springsteen concert , great time
3-18-8 routine exam
3-19 doctor called said psa was elevated
what's a psa?
referred to Uro, had several more blood tests.
PSA steady at 4.75
biopsy  June 08 , 12 cores, 4 on left confirmed , right clear
gleason 3 + 3 T1c
research time.
decieded on open RP, Head of Uro  is my Doctor
Surgery done 10-1-8 by Dr See at Frodoret Hospital in Milwaukee
Cathater out 10-13 no problems
Post op,  organ confined, gleason up to 4 + 3, all clear margins
T2c 20% volume, very good outcome I feel
Incontinent and ED.  Time will tell, was told all nerves  saved.
back to work 11-5-8.
 3,6,9 month psa <0.04 one year <0.04
still use 1 pad per day
 
Walked thru the darkness on the edge of town.


60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2243
   Posted 11/8/2009 12:36 PM (GMT -6)   
I have never heard of Cymbalta used for that purpose. But it is used for neuropathy assocaited with diabetes and for depression. Side effects are usually minimal so it might be worth a 3-4 week try to see if it helps. It should be easy to wean off of at that point, if you dont see progress. Like all meds some people respond well and others wont. Good luck and let us know if you have any success with it.
Michael
Dx with PCA 12/08 2 out of 12 cores positive
59 yo when diagnosed
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
Margins not involved
2 pads per day, 1 depends but getting better,
8/5 1 depend at night only
 started ED tx 7/17, slow go
Great family
Michael


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 11/8/2009 12:49 PM (GMT -6)   
Duloxetine - that is the base name for cymbaltra, from what I read, should not be used for incontinence purposes, it has not been approved for that use, due to some pretty bad side effects including liver damage and sucide attempts.

Folks, don't take it upon yourself to presribe meds, that is the job of doctors. I know how frustrating being wet is and can be, but please don't try to experiment with potentially dangerous drugs.

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out  38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - began IMRT SRT - 39 sess/72 gys cath #8 33 days, 11/2- SP Cath #9 in place


60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2243
   Posted 11/8/2009 1:02 PM (GMT -6)   
David,
That suggestion comes from his DR. so he likely knows more about the medication than you are I. It is in the anti-depressent class so if you read all the warnings on any of those meds it would be cause for concern. But it is something he should work with his Dr. on and not advice from a lay person.
Michael
Dx with PCA 12/08 2 out of 12 cores positive
59 yo when diagnosed
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
Margins not involved
2 pads per day, 1 depends but getting better,
8/5 1 depend at night only
 started ED tx 7/17, slow go
Great family
Michael


geezer99
Veteran Member


Date Joined Apr 2009
Total Posts : 990
   Posted 11/8/2009 1:15 PM (GMT -6)   
I have been on Cymbalta for several years as an anti-depressant. Any anti-depressant carries some risk if suicidal ideation apparently a greater risk with young people. As far as off label use, it is perfectly legal and medically acceptable for a doctor to make such use of a drug. As long as your doctor is supervising your use this is not a particularly dangerous drug. You should ask about his experience with patients stopping Cymbalta -- for some people the newer antidepressants can be hard to quit.

I don't know about Cymbalta for incontinence -- for the last several months I have been on one light pad a day -- never filled. At home I use none and have almost no leakage. No stress leakage, slight urge leakage. By coincidence I see my doctor on Monday` and I'll ask my doctor if he knows anything about this use.
Age at diagnosis 66, PSA 5.5
Biopsy 12/08 12 cores, 8 positive
Gleason 3+4=7
CAT scan, Bone scan 1/09 both negative.

Robotic surgery 03/03/09 Catheter Out 03/08/09
Pathology: Lymph nodes & Seminal vesicles negative
Margins positive, Capsular penetration extensive Gleason 4+3=7
6 weeks: 1 pad/day, 1 pad/night -- mostly dry at night.
10 weeks: no pad at night -- slight leakage day/1 pad.
3 mo. PSA 0.0 - now light pads
6 mo. PSA 0.00 -- 1 light pad/day


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 11/8/2009 3:28 PM (GMT -6)   
Not pretending to be a doctor, thats why I was concerned. Wikapedia has a pretty good piece on the drug and its attempted use for incontinence. You would never hear me suggest that someone not be compliant with his doctor
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out  38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - began IMRT SRT - 39 sess/72 gys cath #8 33 days, 11/2- SP Cath #9 in place


geezer99
Veteran Member


Date Joined Apr 2009
Total Posts : 990
   Posted 11/9/2009 6:12 PM (GMT -6)   
As promised, I asked my doctor this afternoon about Cymbalta for incontinence. He said that he had not heard of that but that earlier antidepressants did have a relaxing effect on the bladder. He said that this could increase capacity and so might help, but that the main issue was that one might promote incontinence with older patients. He said that off the top of his head he could not see enough chemical similarity to Cymbalta to lead him to guess that it would have the same effect. He ended up suggesting that I Google it (thus is the state of medical research)
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