Ya Gotta Read This......

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JoeyG
Regular Member


Date Joined Jul 2009
Total Posts : 162
   Posted 11/9/2009 9:46 AM (GMT -6)   
I know that most of you are aware of a "miraculous" discovery in May that seemingly cured two men that had metastatic PCa. This is an article from the Mayo Clinic that gives more information:
 
 
Can we be on the verge of finding a cure for PCa, as well as other hormonal dependant cancer (or at least a treatment that may extend life significantly, without dire quality-of-life concerns)????
 
If this has already been discussed extensively, I apologize.
Age -57; Diagnosed 10/05 PSA 13.4 GS 9 Organ confined (T2B)
Cryoablation 4/06 Allegheny Hosp-Dr Ralph Miller (Cohen/Miller)
Post Cryo Nadir 8/06 0.2
Rising steadily to 0.7 4/09 :-(
Steady at 0.7 (7/09) (Pomegranate???)
Looking to take next steps soon
Hoping to qualify for salvage cryo or radiation


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 11/9/2009 10:02 AM (GMT -6)   
Amazing article, thanks for posting, I hadnt seen or read it before
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out  38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - began IMRT SRT - 39 sess/72 gys cath #8 33 days, 11/2- SP Cath #9 in place


JoeyG
Regular Member


Date Joined Jul 2009
Total Posts : 162
   Posted 11/9/2009 11:06 AM (GMT -6)   
I have to wonder in a clinical trial, why would one need to have a control group here? We all know the outcome of metastatic cancer---anything that would clear out the tumors and lower the psa would be a huge success. I am hoping that a lot of focus and effort goes forward on this immediately and I would spearhead a nation-wide effort to help get private money for funding. I will be doing some homework and sending out some e-mails SOON.
Age -57; Diagnosed 10/05 PSA 13.4 GS 9 Organ confined (T2B)
Cryoablation 4/06 Allegheny Hosp-Dr Ralph Miller (Cohen/Miller)
Post Cryo Nadir 8/06 0.2
Rising steadily to 0.7 4/09 :-(
Steady at 0.7 (7/09) (Pomegranate???)
Looking to take next steps soon
Hoping to qualify for salvage cryo or radiation


Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1210
   Posted 11/9/2009 11:37 AM (GMT -6)   
Hi JoeyG,
 
Thanks for the URL to this exciting research report. It would be absolutely wonderful if it should prove to as effective as seams to be. Another ray of hope for all of us. Sure hope it's not another dead end like so many other attempts to beat the beast.
All the best to you.
 
Magaboo

Born Sept 1936
PSA 7.9
-ve DRE
Gleason's Score 3+4=7, 2 of 8 positive
open RP 28 Nov 06 (nerve sparing), Post op staging T3a
Gleasons still 3+4=7
Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; 3 days before Rad Start=0.1
Salvage RT completed (33 sessions - 66 Grays) on the 19th Dec., 08.
PSA in Jan., 09, = 0.05; July 09, <0.04


geezer99
Veteran Member


Date Joined Apr 2009
Total Posts : 990
   Posted 11/9/2009 1:06 PM (GMT -6)   
An interesting result, especially for our brothers with advanced PC (for everyone else -- screening, screening, screening)

This study shows a way of getting a tremendous boost to the effectiveness of hormone therapy. One issue will be is this knocking out the cancer, or just knocking it down for a while?


Now comes the longer part of the research. Particularly the enumeration of risks and side effects. With patients like those described here, the risk from their cancer is so high that a lot of treatment risk is acceptable.
Age at diagnosis 66, PSA 5.5
Biopsy 12/08 12 cores, 8 positive
Gleason 3+4=7
CAT scan, Bone scan 1/09 both negative.

Robotic surgery 03/03/09 Catheter Out 03/08/09
Pathology: Lymph nodes & Seminal vesicles negative
Margins positive, Capsular penetration extensive Gleason 4+3=7
6 weeks: 1 pad/day, 1 pad/night -- mostly dry at night.
10 weeks: no pad at night -- slight leakage day/1 pad.
3 mo. PSA 0.0 - now light pads
6 mo. PSA 0.00 -- 1 light pad/day


STW
Regular Member


Date Joined Jun 2009
Total Posts : 292
   Posted 11/9/2009 1:14 PM (GMT -6)   
Wow!
Diagnosed at 54
PSA 8.7 Biopsy 1/7/09
4 of 6 cores positive, one at 90%
Gleason 3+4=7 Neg bone scan 1/15/09
One shot Lupron Depot 1/27/09 Tax Season
RP 4/29/09
Neg lymph nodes, postive seminal vesicle, 1 positive margin
Gleason 3+4=7 with tertiary 5
Catheter out at 2 weeks no nighttime incontinence Pad free week 5
PSA 6/6/09 <0.1 PSA 9/10/09 <0.1

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