PCA3 Test - Is there a Value once Diagnosed?

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Regular Member

Date Joined Nov 2009
Total Posts : 98
   Posted 11/12/2009 7:50 AM (GMT -6)   
There's no doubt that I have PCa.  As I struggle to decide treatment (surgery or seeds are at the top of the list, at least for today), I'm wondering if having a PCA3 test would provide data points that could help the decision cycle.  Any opinions anyone would like to share?  TIA. 

Age 52, PSA 8.7 Biopsy - 4/12 cores , Gleason 3 + 3 = 6

Cajun Jeff
Veteran Member

Date Joined Mar 2009
Total Posts : 4119
   Posted 11/12/2009 8:27 AM (GMT -6)   
Welcome. I know that you have been reading the forum and getting much info. Only you can make the decision as to which treatment is best for you. Gather as much info as you can.

With a Gleason 6 you have some time to make a decision. So many time we make rushed decision simply because of the C word. A Gleason 6 is usually means that it is slow growning. Get a second opinion or even a 3rd, concerning different treatments.

I know that you head is spinning at this point. We have all been there. If you have specific questions do not hesitate to ask. You can be sure that someone on the board has had the situation that you would be asking about.

I suggested to a few others you my want to make an e-mail address for members to reply directly to you on some personal matters. You can make an e-mail address on HW just for that purpose.

Best of Luck
One of the PC Brothers.

Jeff T
Cajun Country
Jeff T Age 57

9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable

10th month PSA <0.01
1year psa <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next. Next step injections.

Regular Member

Date Joined Nov 2009
Total Posts : 98
   Posted 11/12/2009 8:52 AM (GMT -6)   
Let me check my profile, but I was almost certain I included an e-mail contact so I could get notes......standby.....Okay, operator error, I included an address but did not check to make it viewable - resolved.

Age 52, PSA 8.7 Biopsy - 4/12 cores , Gleason 3 + 3 = 6

Worried Guy
Veteran Member

Date Joined Jul 2009
Total Posts : 3741
   Posted 11/12/2009 1:29 PM (GMT -6)   
Great question Defender,

I spent a little while reading up on PSA3 and its genetic marker and it left me like you, wondering what it would accomplish.
Let's say you do the test. It will likely show you have a genetic disposition to PCa. Unless you are considering only a vasectomy would that change your treatment decision in any way? What if it shows you don't have the marker? You already have PC. So if the test outcome will not affect your decision why do it? Unless you are doing it as a control study for science I don't see the point.

This test seems like a neat way to identify people who might have PCa down the road. I hope employers never use this to screen for employees with potential health issues. A slippery slope indeed.

Maybe someone else sees something we're missing.
Good luck with whatever you decide.
DX Age 56. First routine PSA test on April 8th: 17.8.
May PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, Gleason 6=3+3. Bone scan and C/T scan negative.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7 Tumor size: 2.5 x 1.8 cm location: both lobes and apex. No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Extraprostatic extension present; Perineural invasion: present, extensive
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 10/31 3 months, Still no activity, nada, zip
Incontinence - 8/20 4 full pads per day
. 9/7 3-4 full pads per day (I'm going to try cutting down on fluids. Bad idea. I know.)
9/17 2 months: Still 3 pads per day.
10/31 14 weeks: Still 3 pads per day. At this rate I'll be fine in 2012.
Post Surgery PSA - 9/3 6 weeks- 0.05, 10/13 3 months- 0.04 undetectable.

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