Hormone therapy question

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compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7204
   Posted 11/23/2009 1:05 PM (GMT -6)   
I am reading posts where some folks say they would not get hormonal therapy. Period.
 
From my reading, there are numerous side effects, many sound horrible.
 
For those getting hormonal therapy, what side effects are you getting? Are you able to combat the effects? Does it seem to be controlling your cancer reasonably well for a reasonable length of time?
 
What specialist would one see if such was the case?
 
Mel
PSA-- 3/08--2.90;  8/09--4.01; 11/09--4.19 (Free PSA 24%), this after 45 days on cipro!
 
History of BPH/prostatitis.
 
Awaiting results of my PCA-3 test which will determine whether a biopsy is in my immediate future. Just in: BAD NEWS: PCA-3 = 75.9! Cut-off is 35. Biopsy scheduled for 11/30


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4225
   Posted 11/23/2009 1:19 PM (GMT -6)   
Mel,
I was on Casodex for 6 months and the only issue I had was hot flashes a couple of tmes a day lasting a couple of minutes. You have a complete loss of libido, which means you have no desire whatso ever for sex. All side affects disappear after you have been off it for a few months.
My cousin has been on intermittant therapy for 10 years and my neighbor on continuous for 12 years, neither of them have serious problems with it and are able to live completely normal lives. I guess as with everything else people react differently, some having severe side affects and other having very few. You really need an oncologist to administer the therapy or at least suggest and monitor a protocol that a local doctor can administer. He can vary the dose and substitute meds as necessary to reduce the side affects.
JohnT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.

JohnT


Casey59
Veteran Member


Date Joined Sep 2009
Total Posts : 3172
   Posted 11/23/2009 3:03 PM (GMT -6)   
If someone has a low risk case of PC, HT wouldn't be their primary choice unless there were unusual circumstances, as it is not curative.  Low risk cases usually have the most options.  Sometimes HT is used to complement a curative treatment.  On the other hand, for advanced cases, it is often the best option among a much more limited set of options.
 
 
compiler, I had a follow-up question for you back on an earlier thread.  Would you mind going to this thread:  http://www.healingwell.com/community/default.aspx?f=35&m=1649454.  Thanks in advance.

Hopeful in MD
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 11/23/2009 9:00 PM (GMT -6)   

Mel,

From my perspective, it seems that you need more info that a biopsy could provide.  I agree with Compiler that HT would most likely not be the first choice. 

However, be that as it may, I am on Lupron after failure of seed implants - started Apr. 21, 2009.  Fatigue and hot flashes at first.  Now just hot flashes that come and go.  Second shot was Aug. 21, next due Dec. 21. Hot flashes not bad enough to need meds to control them.  Libido is zilch, but at 70, not too concerned.

I believe that there are some things much worse than the side effects that I have.  So far, no serious probs with moods or anything like it. 

Good luck with followup exams / consultations.

Gene in Md 


Age 70.
Dx Dec 07. PSA 8.4. DRE confirmed tumor. Three of six positive. Gleason: 6 (3+3). Seeds Iodine 125 Jan 08. PSA's 3.9, 1.7. Rising PSA's: 2.3, 3.4, 3.9, indicating  seeds not working.  April 09 began HT with Lupron 30 MG ea. 4 mos.  Side effects hot flashes, severe fatigue until mid-July. Jun 09 - Onco DRE negative for nodules - hooray!!! Aug 09 - PSA 0.5!!!  Lupron working! Aug. 21 - 2nd Lupron shot.  Aug. 31 - hyperbaric oxygen for rectal bleeding (radiation proctitis).  40 sessions as of Nov. 9.   Nov. 5 sigmoid exam - gastro "oxygen not working." Hyperbaric doc "they are" confirmed by Nov pics compared to Sep. Will continue treatments up to 60, the max nr for one course of treatments. 

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